The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

Developmental and Educational psychology is concerned with the developmental course and dynamics of cognition, self-regulation, and emotional competence, and the implications for educational and clinical practice.

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

How do you experience a quieter city? Or a silenced city? Our cities are normally filled with noise. The corona crisis has changed that. Few or no people on the streets, shops closed, much less traffic, hardly any planes coming over. The soundscape of the city has completely changed. Soundtrackcity,…

Four Leiden researchers have each been awarded a consolidator grant of up to 2 million euros by the European Research Council (ERC). They carry out research on a diverse range of subjects, from gender stereotyping in the field of science to making sugar molecules.

Geneticist Hans Clevers will give the first Niko Tinbergen lecture new style on 10 December, which is all about stem cells. The young Leiden professors Ariane Briegel and Susana Chuva de Sousa Lopes talk about bacterial noses and the cultivation of egg cells in the lab in short introductory lectures…

Kidney failure is a serious issue because kidneys cannot regenerate themselves after injury. A possible solution consists of artificially growing healthy kidney tissue. To achieve that, scientists first need to understand kidney development during the earliest stages, in the fetus. Leiden researchers…

The aim of this project was to estimate emissions from lead products-in-use for the past, the present and the future and assess the development of toxicological risks associated with these products.

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Reading emotions from others’ faces strengthens social relationships. But how is that for children with hearing loss? Can they learn to read faces just as easily as hearing children? The study by Yung-Ting Tsou and colleagues shows that daily

Why does one person radicalize to involvement in terrorist violence within a group-based context, while another engages in this form of violence alone?

Is blended care a feasible and effective treatment method for social anxiety in adolescence?

Students at Leiden University College (LUC) gain an understanding of journalism ‘from the inside out’ through innovative teaching methods in the courses Multimedia Journalism, Investigative Journalism and Gender, Media and Conflict. By simulating the actual daily tasks of journalists, they are exposed…

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

On 30 September 2021 Babette van Hazebroek defended her thesis 'Understanding delinquent development from childhood into early adulthood in early onset offenders'. The doctoral research was supervised by Prof. J.W. de Keijser and Prof. A. Popma (VUMC).

To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.

National parochialism is the tendency to cooperate more with ingroup than outgroup members. Angelo Romano, Matthias Sutter, James Liu, Toshio Yamagishi & Daniel Balliet studied national parochialism across different nations and conclude in their publication in Nature Communications that it is a ubiquitous…

The ‘Leer te Durven!’ program (Learn to Dare) is a preventive training program for children with mild anxiety symptoms (Simon & Bögels, 2014). The program has been developed for children between the ages of 8 and 12 who feel or behave anxiously, avoid situations, are afraid of doing things wrong, appear…

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

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Intensive public debates have erupted about integration of immigrants in Europe. The influx of refugees from the middle east during the summer and autumn of 2015, the increasing visibility of immigrants throughout European societies, but also the widely publicized occurrences on New Year’s eve in Cologne…

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

Overview of CML software and data

Examining mediation and moderation.

Clinical psychology is a discipline concerned with the application of psychological science to the assessment and treatment of mental disorders.

The master’s programme in Psychology in Leiden focuses both on in-depth study of psychological theory as well as on the acquisition of professional and research skills. Students develop their knowledge of psychology as a science and its application in order to effectively address relevant issues. The…

The master’s programme in Psychology in Leiden focuses both on in-depth study of psychological theory as well as on the acquisition of professional and research skills. Students develop their knowledge of psychology as a science and its application in order to effectively address relevant issues. The…

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

PhD defence

Writing an operational guide to the ISO standards for LCA and related sub-projects.

Birds sing to be heard, but how do they cope with increasing noise levels? Which species persist in cities and why? And do they thrive or suffer in the urban soundscape?

Improving environmental risk assessment of pesticides in surface waters

Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.

This project aims to identify, quantify and map the exposure of Dutch national monuments to four climate change effects: flooding, waterlogging, drought and heat.

Sasse, van Breen, Spears & Gordijn demonstrated an anger gap in response to sexism which was larger for women than for men and found evidence that expressed anger was associated with instrumental concerns.

Effectiveness of an early intervention program for anxiety-prone toddlers in the Netherlands

Our research in the area of safety sciences aims to increase the mechanistic understanding of cellular toxicity of drugs and, in a broader sense, chemicals.

In this article, Lydie Cabane, Assistant Professor at the Institute of Security and Global Affairs, and Martin Lodge address the question of how to manage banking crises, a question that has gained prominence since the banking crisis of 2007-2009. This article sets out the rationale for regulating for…

Band 69 | 2014

Do natural soundscapes affect migratory decisions of fishes moving up and down rivers and is this process disturbed by vessel sounds?

A study by a Leiden-Wageningen group shows that present-day humans are biologically poorly equipped to deal with the toxins they are regularly exposed to in smoky environments: compared to earlier hominins, we modern humans are probably even worse off. The study appeared in Molecular Biology and Evolution.…

The aim of this project is to investigate the (cost)effectiveness of two innovative forms of trauma-focused therapy for patients with childhood abuse related PTSD. The ultimate goal is to improve quality of care and contribute to treatment innovation for this severely ill target population.

Are traces of fire use detectable in ancient hominin genomes?

Research how ‘custom’, ‘traditions’ and ‘heritages’ take on new meanings in the uplands of South and (mainland) Southeast Asia.

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.