Can we bring novel treatment options to the clinic for UM patients with liver metastases?

Volume 4 and 5 of the Leiden series 'Dutch Sources on South Asia' are now available, written by Markus Vink (vol.4) and Carolien Stolte (vol.5).

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Currently the focus of the project is the development of a tool that utilizes dimensionality reduction techniques in order to analyze and interpret the lexical and phonological variation between different sign languages. Additionally, the application of deep learning techniques for the extraction of…

- Which metabolites could be components of NADES? - How can we prove the presence of NADES in nature? - What are the roles of NADES in nature? - How to apply NADES in life sciences?

What socio-cultural transformations did indigenous communities in the Lesser Antilles undergo from the late precolonial to the early colonial period in response to Amerindian­ European-African cultural encounters? How did Amerindian populations realign themselves in response to the colonisation…

How was the future United Nations Organization promoted to global publics during WW II?

This book brings together a collection of emergent research that moves the debate on desistance beyond a general consideration of individual and social structural influences.

Subproject of

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

The book offers different theoretical perspectives to help examine the process of public sector reform. In addition it gives an overview of the major trends in the core areas of the functioning of the public sector.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

On the 11th of June, Umberto Selva successfully defended his doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Umberto on this great result.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

In this study, Bibi van den Berg and Sanneke Kuipers from ISGA, explore the ways in which cyber-related incidents may lead to crises

The project concerns the nature, the usages and functions of pictographic systems in relation to writing in societies with (restricted) literacy.

The master's in Hebrew and Aramaic Studies, a specialisation of the Classics and Ancient Civilizations programme, at Leiden University explores Classical Hebrew and Aramaic Studies in the broadest sense.

The research master's in Hebrew and Aramaic Studies, a specialisation of the Classics and Ancient Civilizations (Research) programme, at Leiden University explores Classical Hebrew and Aramaic Studies in the broadest sense.

On the 23d of May, Sanne Rotmeijer successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Sanne on this achievement!

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

This project has two main aims: I. Determine when novelty promotes fear extinction. II. Discover the neurobiological mechanisms underlying these effects.

Rising geopolitical tensions are causing states and national elites to innovate their use of the past for present-day political ends. This is certainly true for the People’s Republic of China, which prepares to celebrate its 75th anniversary in 2024 amid mounting superpower rivalry, ideological tensions…

Following the terrorist attacks in Paris (November 2015) and Brussels (March 2016), Belgium’s counterterrorism policy has been heavily criticized – domestically and worldwide.

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

Ramautar

How does a Leiden alumnus end up working at the New York Metropolitan Museum of Art (The Met)? In the case of Daniëlle Kisluk-Grosheide, it was partly down to chance, luck, fate. But that was preceded by a unique degree in decorative arts in Leiden.

A portrait of the complex historical process of over 500 years of European colonialism in the New World.

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

This collection explores how immersive technologies affect newsmaking and the positive and negative impacts they may have on journalistic norms, professional ethics, audience engagement, and data protection.

How does stress influence cognitive performance? What is the role of selective attention to threatening information in this effect? Could we prevent stress-induced decline of cognitive performance with pharmacological interventions? Could we use resting state theta/beta ratio as a biomarker for cognitive…

When the tokay gecko loses its tail, a new one grows from resident stem cells at the stump. Each tissue type - muscle, bone, blood vessels and skin - develops from specific stem cells. This discovery by Luthfi Nurhidayat holds potential implications for advancing regenerative medicine in humans. Nurhidayat…

With the emergence of social media platforms such as Twitter, Facebook and Instagram, it’s easier than ever to share information. Including disinformation. During his PhD computer scientist Xueqin Chen developed a new way to recognise fake news and predict how messages spread within online social networks…

Aim of the proposal is to develop lugdunomycin into a drug candidate able to treat infectious diseases caused by multi-drug resistant pathogens.

Part of ‘Moralising Misfortune: A comparative anthropology of commercial insurance’, an ERC Consolidator project of Erik Bähre.

Two previous English translations of this classic essay by Georg Simmel have been in wide circulation, shaping the worldwide reception of Simmel’s urban theor

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

What forms does religiosity take among Muslims in Europe today? How are answers to the question of what it means to be a Muslim in Europe reached in institutions of Islamic higher education, Muslim student organizations, and women’s organizations? What is the relation between the individual and religious…

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

How do academics develop into novel researcher roles alongside current teacher roles in the context of new universities in transition?

Does the δ-machine have higher accuracy than the other feature-based classifiers in some conditions?

This project aims to develop advanced data analysis methods for monitoring and increasing our understanding on biodiversity dynamics in nature reserves such as the Oostvaardersplassen.

The 9th Network Europe Conference in Edinburgh was held at June 2017 in Edinburgh and organized by the Europa Institut Zurich. The contributions of the conference are now published.

Carlotta Rigotti co-authors a new publication on EU law and image-based sexual abuse in the German Law Journal.

This book explores the relationship between the production of new urban spaces and illiberal community-making in contemporary India. It is based on an ethnographic study in Noida, a city at the eastern fringe of the state of Uttar Pradesh, bordering national capital Delhi.

Staging the Archive: Art and Photography in the Age of New Media is dedicated to art practices that mobilize the model of the archive, demonstrating the ways in which such archival artworks probe the possibilities of what art is and what it can do.

How did the medieval manuscript develop as a physical object during the Twelfth Century Renaissance and what do these changes tell us about the intellectual culture of the period?