Promotor: A. Kros

The Board of Governors of Leiden University is pleased to announce that the outgoing Minister of Education, Culture and Science, Robbert Dijkgraaf, has appointed Professor F.B.J. (Ferd) Grapperhaus as the new Chair of the Board of Governors.

- Which metabolites could be components of NADES? - How can we prove the presence of NADES in nature? - What are the roles of NADES in nature? - How to apply NADES in life sciences?

Ymre Schuurmans, Professor of Constitutional and Administrative Law, has been appointed Chair of the Dutch Legal Aid Board’s Advisory Council following permission from the Dutch Minister for Legal Protection.

Prof. dr. Pancras Hogendoorn is stepping down as dean of the Faculty of Medicine and vice-chair of the Executive Board of Leiden University Medical Centre (LUMC). He is also resigning from all associated secondary posts. Hogendoorn has taken his decision in anticipation of the findings of an inquiry…

Clinical psychologist Bernet Elzinga has been appointed as Professor of a personal chair at the Faculty of Social and Behavioural Sciences. This professorship will contribute both nationally and internationally to the broader promotion of Leiden University in the field of stress and psychopathology.

Mariana Gkliati participated on Saturday 2 June at ‘Europe on Trial'.

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We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

By delivering his inaugural lecture titled ‘Where Science Meets Business,’ Simcha Jong accepted his appointment as Leiden’s first Professor of Science Based Business. In his lecture in the Large Auditorium of the Academy Building, Simcha argued that broad universities with a focus on fundamental research,…

The Council of Ministers has appointed Jan Willem Erisman, Professor of Environment and Sustainability at Leiden University, as chair of the new Scientific Climate Council (WKR) from 1 March. This council will advise the government on climate policy.

A starring role for PhD candidate Andreea Nadaban during the annual meeting of the European Epidermal Barrier Research Network. With her talk about the arrangement of lipid molecules in the upper layer of our skin, she won the award for Best Oral Presentation.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

The Supramolecular & Biomaterials Chemistry group comprises the PIs Alexander Kros, Roxanne Kieltyka, Gregory Schneider and Sander Wezenberg, and is active in the field of self-assembly of amphiphilic peptides and applying them in supramolecular chemistry.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids.

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

This book, edited by Joost Augusteijn, Constant Hijzen and Mark Leon de Vries, explores how democratic regimes have dealt with anti-democratic forces in society, from the late nineteenth to the early twenty-first century.

The Ministry of Home Affairs and Kingdom Relations (BZK) is establishing two new professor chairs for the Kingdom.

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

Macrophages and atherosclerotic lesions The infiltration of monocytes in the arterial wall, their differentiation to macrophages, and the subsequent accumulation of cholesterol in these macrophages initiate the process of atherosclerosis. We study the importance of specific genes in macrophages for…

Synthetic cells, also known as artificial cells or protocells, have wide ranging applications from drug delivery vectors to cell models. In biotechnology they can function as micro- or nanoreactors with possible applications in biocatalysis and photocatalysis. Phospholipids are by far the most commonly…

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Pharmacologist Walter Boiten developed a new method to determine the amount of lipids in a person's skin. With this method he tested the effects of a new cream he developed for eczema patients. The first results are promising. Boiten defends his dissertation on 15 January.

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

Many metalloenzymes that are key to bioenergetics are membrane enzymes, with canonical examples the complexes I, II, III and IV in the mitochondrial inner membrane. To study these enzymes in a native-like lipid membrane environment, we aim to develop novel bioelectrochemical techniques.

On Thursday 24 November 2016 Moses George will defend his PhD dissertation ‘Legal Implications of Airport Privatization in India’. The defence will commence at 11.15 hrs, in the Academy Building of Leiden University. The Supervisors are Professor Pablo Mendes De Leon and Professor Brian F. Havel (DePaul…

Sofia Ranchordas (1985) has been appointed Chair European and Comparative Public Law and Rosalind Franklin Fellow at the University of Groningen. She will start this position on October 1st.

On Saturday 17 November 2018 Vestert Borger chaired a panel at the conference ‘The EMU at Twenty’.

The Executive Board and Management Board of the EU Fundamental Rights Agency will meet from 13 to 15 December, with Rick Lawson as Acting Chair.

Dr Moritz Jesse, European Institute at Leiden Law School, has been awarded a Jean Monnet Professorship. From November 2023, Moritz will teach bachelor's and master's courses as part of his ‘Migration, Integration, Non-Discrimination in the EU’ project [MIND-EU]. At a later stage, Jesse’s Jean Monnet…

The Pension Funds Dispute Authority (GIP) was founded on 1 January 2024. Albert van Marwijk Kooy has been appointed Chair of the Dispute Resolution Committee, which forms part of the GIP.

Those who seek justice do not always manage to find their way through the legal system. Yet the Dutch Legal Aid Act assumes that citizens are self-reliant and can stand up for their interests in cases that are not legally complex. However, in the childcare benefits affair in the Netherlands, this proved…

22 September 2017 the second biannual conference took place organised by IAAEU of the University of Trier and the Hugo Sinzheimer Institute of Frankfurt. The theme of the conference was the European Pillar of Social Rights. Under the heading of the conference’s title, International Labour Law as a stimulus…

A study has been initiated at the instigation of WODC (Scientific Research and Documentation Centre) on the judicial monitoring of big data applications by government. The study is being conducted by TILT (Tilburg Institute for Law, Technology, and Society).

On November 23, 2017, Professor Simone van der Hof chaired a panel on age verification in the digital world at the Safer Internet Forum 2017 in Brussels.

On 1 December 2023, Fatma Çapkurt was appointed as deputy chair of the State Committee on the Rule of Law.

The Europa Institute is delighted to announce the appointment of Freya Baetens to the Chair in EU External Economic Law.

Prof. dr. Arnold Tukker will be appointed on 1 October 2013 as Chair of Industrial Ecology at the Faculty of Science of Leiden University. He will work at the Institute of Environmental Sciences (CML), and also become the new director of this institute.

In the light of today’s major changes and challenges, the congress on November 22 will focus on Redesigning the Designer while also taking some of the examples of more-than-human knowledge experimented with within Neuhaus as a starting point for a new network.

Policymakers and Academics Speaking with Each Other