319 search results for “centre metastasis” in the Public website
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Unraveling the role of signaling networks controlled by Grainyhead like transcription factor in breast cancer subtypes
This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…
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LUCIS - Centre for the Study of Islam and Society
LUCIS promotes high-quality research on Islam and Muslim societies and actively communicates the insights and findings of that research to the larger public.
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Leiden researchers discover genes that affect spread of breast cancer
Researchers at Leiden University have mapped genes that cause breast cancer cells to migrate. The Leiden toxicologists Professor Bob van de Water, Dr Wies van Roosmalen, Dr Sylvia E. Le Dévédec and colleagues studied 1500 individual genes. They found eight, including the SRPK1 gene, that regulate the…
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Erik Danen appointed as Professor of Cancer drug target discovery
As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.
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Ewa Snaar-Jagalska
Science
b.e.snaar-jagalska@biology.leidenuniv.nl | +31 71 527 2727
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Role of Chemokine Gradient Sensing in Ewing Sarcoma Progression, Angiogenesis and Immune Targeting
What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?
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Mickler, Parliamentary Committees in a Party-Centred Context
Beyond the immediately visible plenum, parliaments are highly complex institutions. They work through various venues in which decisions are prepared or even taken. The two main institutions in this regard are parliamentary party groups, which comprise legislators who are elected under the same party…
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XIV Annual Convention of the Austrian and Central European Centres in Leiden
Impressions by Wouter Baas and Caroline Schep
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Thomas Schmidt Lab - Single Molecule Microscopy
Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.
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Luca Giomi Group - Soft and Bio Mechanics
We are interested in understanding the mechanics of soft materials, of which biological materials are prominent examples.
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X Anniversary Convention of the Centre of Austrian Studies in November 2016 in Jerusalem
Impressions by Martin Küster, Master of Arts.
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Grotius Centre contributes to ICC ASP Expert Discussion on Effectiveness and Efficiency
On 24 November 2015, Prof. Carsten Stahn participated as external expert in a special plenary session of the Assembly of States Parties on the efficiency and effectiveness of Court proceedings, chaired by the co-chairs of the Study Group on Governance of the Assembly.
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How oxygen deprivation causes cancer cells to spread
In breast cancer, metastasis rather than the primary tumour is the cause of death. A lack of oxygen in the tumour cells promotes this metastasis, accompanied by a reprogramming of the cell's metabolism. PhD candidate Qiuyu Liu investigated these alterations to get more knowledge about the actionable…
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Osteosarcoma: searching for new treatment options
Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen
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Computational Biology
Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.
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Small molecule prevents tumour cells from spreading
Leiden chemists, together with colleagues at the University of York (UK) and Technion (Israel) have discovered a small, sugar-like molecule that maintains the integrity of tissue around a tumour during cancer. This molecule prevents tumour cells from spreading from the primary cancer site to colonise…
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Ariane Briegel
Science
a.briegel@biology.leidenuniv.nl | +31 71 527 8850
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Modelling metastatic melanoma in zebrafish
Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.
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700,000 euros for the fight against aggressive breast cancer
To inhibit proteins that contribute to the growth of aggressive cancer cells, that’s the plan of Professor Bob van de Water and his team. They will receive over 700,000 euros from the KWF Dutch Cancer Society for their research. Researcher Maaike Vreeswijk and pathologist Danielle Cohen are affiliated…
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Calendar Academic Language Centre
Important dates in the Academic Language Centre calendar
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Deep: Using simulations to understand the excess baryonic mass in the centres of high-mass, early-type galaxies
This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…
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Dual PhD Centre
December marks the 15th anniversary of the Dual PhD Centre (DPC). Director Johannes Tromp and associate professor Mark Dechesne look back and ahead. Dechesne: ‘The DPC forms a 'community of knowledge' in which science and society are connected.’
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Drug Discovery & Safety
In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.
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Cancer Drug Target Discovery
In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…
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Sports Centre celebrates 50 years
Online competitions, online sports, dietary advice for staff and students and 'What do they eat for lunch?' The first 'volunteer' is Vice-Rector Hester Bijl. What does her lunch usually consist of? The University Sports Centre is celebrating its fifty-year anniversary with a whole - corona-proof - programme…
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How metastatic tumours manipulate their environment
Tumours act like mini-organs, manipulating their environment and using bodily processes to survive and metastasise. Through research by Erik Danen and his colleagues, we are learning more about the complex nature of tumour cells. In the Dutch newspaper NRC, the scientists discuss their findings.
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Leiden Leadership Centre Summer Café
Last Friday, June 3rd, students, professionals and academics put their knowledge to the test during the Leiden Leadership Pubquiz/Leiden Leadership Summer Café. The pubquiz, hosted by Eduard Schmidt, touched upon public leadership in the news, posed statements about remarkable leadership research, and…
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and properties of dark matter using the stellar kinematics in the centres of ultra-faint dwarf galaxies
Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.
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2011 Leiden Centre for Global Heritage
A Centre for Global Heritage will be set up at Leiden University, that integrates the unique global breadth and quality of academic expertise at the University and the Leiden Museums with the global infrastructure of practical consultancy expertise built up over the past years by the Centre for International…
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PROPER: ‘Near-patient’ prostate cancer models for the assessment of disease prognosis and therapy
How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?
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New strategy LDE Centre for BOLD Cities
The Leiden-Delft-Erasmus Centre for BOLD Cities uses multidisciplinary big data research to help find solutions for urban problems. ‘BOLD’ stands for ‘Big, Open and Linked Data’. Data science is one of the Centre’s main disciplines.
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More powerful data centre will accelerate research
Language evolution, targeted drugs or archaeological interpretation. Researchers are making increasing use of supercomputers that can rapidly process large quantities of data. This is one reason why the University data centre will be extended and updated. ‘Datamining means we can get a better picture…
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Opening Beehive Student Centre in The Hague
The new student centre in The Hague, the Beehive, will be opening its doors in stages starting from 1 October. The name Beehive was chosen because it stands for connection, an individual identity, activity and belonging. This meeting place for students is dedicated to improving the living environment…
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Coming soon: new sports and examination centre
A sustainable building that is both sports and examination centre. In September, a design team including architect Atelier PRO will begin to develop the plans for the new University Sports Centre (USC). Construction will begin in 2021, and the building is expected to be completed before September 2022.…
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Jean Monnet Centre of Excellence on comparative regional integration awarded to Leiden University
Leiden University is happy to announce that it has won a prestigious Jean Monnet grant for a Centre of Excellence. The Centre, called CompaRe, focusses on comparative regional integration.
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Cell Systems and Drug Safety
The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…
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Joni Reef at opening Expertise Centre KIND
Joni Reef was among those present at the opening of Expertise Centre KIND in 's-Hertogenbosch on Thursday 22 November 2018. She spoke to Dutch newspaper Brabants Dagblad afterwards.
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Bob van de Water
Science
water_b@lacdr.leidenuniv.nl | +31 71 527 6223
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Conference Hazelhoff Centre for Financial Law
On the occasion of its fifth anniversary, the Hazelhoff Centre for Financial Law will organize a conference on ‘Public and private regulation of financial markets’ on 11 May 2017.
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Leiden Leadership Centre: Winter Holiday Tips
To enjoy the Winter holidays, the Leiden Leadership Centre has selected several interesting illustrations of leadership.
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Alternative Humanities Campus in Leiden city centre
Leiden University and the Municipality of Leiden will develop new plans for an alternative Humanities Campus in the city centre. This means they will not proceed with the compulsory purchase of the De Doelen housing complex to facilitate the construction of the new Humanities Campus. The plans to demolish…
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Hague campus to become international academic centre
Within the next five years, Leiden University wants its campus in The Hague to become a leading international academic centre with research and teaching that correspond with the city’s profile. All of the faculties will help achieve this, and the University has also signed a partnership agreement with…
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Armin Cuyvers gives inaugural lecture of the European Legal Studies Centre of the Universitas Indonesia, Jakarta
On 30 October 2020, Armin Cuyvers was invited to give the inaugural lecture of the European Legal Studies Centre of the Universitas Indonesia, Jakarta.
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123 refugees in University Sport Centre
Preparations for receiving 123 refugees in the University Sport Centre have been in full swing for several days. The large sports hall will be transformed into a dormitory, and a living and dining area. There will also be two recreation areas, one for adults and one for children.
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Retrospective 75th anniversary African Studies Centre Leiden
A ‘world class institute’ with a ‘vibrant atmosphere’, doing research on a continent that is ‘becoming increasingly important’. That is how Annetje Ottow, president of Leiden University’s Executive Board, described the African Studies Centre Leiden (ASCL) on its 75th anniversary celebration on 8 September…
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The Kattekop again voted best childcare centre in South Holland
The University's childcare centre, de Kattekop, has been awarded the 2017 Regional Award by South Holland. In an independent survey, parents gave the centre an exceptional score of 9.4,.
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New Leiden Centre of Archaeological Studies in Italy
The Faculty of Archaeology has a new Centre of Archaeological Studies in Italy.