Discovering effective new drugs is a long, expensive and uncertain process. Laura Heitman wants to improve this by finding out more about how drugs bind to proteins that play a role in disease. She calls it ‘drug discovery 3.0’. Inaugural lecture on 9 December.

Nature Reviews Drug Discovery volume 18, pages 82–84 (2019). The implications of target saturation for the use of drug–target residence time Wilbert de Witte, Meindert Danhof, Piet van der Graaf, and Elizabeth de Lange

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

There are more molecules that could conceivably be candidate drugs than there are stars in the universe. How can we ever efficiently identify those molecules? Professor of AI and Medicinal Chemistry, Gerard van Westen: ‘I’m going to use artificial intelligence as the co-pilot to make an automated search.’…

We are very happy to welcome you to spend a semester or year studying or doing an internship with us at the Leiden University Medical Center. Here you will find information on your course timetables and registration.

Can effective synergists be identified to enhance the effect of antibiotics against Gram negative pathogens?

Developments in globalization and industrialization continuously push governments, international organizations and NGOs to reexamine the opportunities available to people at all levels of society to attain basic socioeconomic necessities. Research into existing social justice initiatives has shown a…

As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.

The GMP Facility facilitates development and production of Advanced Therapy Medicinal Products (ATMPs) and chemical (peptide) synthesis.

Promotor: A. Kros

The Leiden University Center for Statistical Science unites the statisticians teaching and researching at Leiden University.

Workshop

This project develops a scientific method to extract clinically relevant new information from patient forum websites that discuss patient experiences concerning e.g. medication, nutrition, co-morbidities, genetic factors etc.

Explaining the origins , patterns and outcomes of crisis management efforts.

The Center for Interdisciplinary Placebo Studies Leiden (IPS) aims to advance the understanding of placebo and nocebo effects, their underlying mechanisms, and their potential applications in clinical practice. IPS consists of a group of interdisciplinary researchers working at Leiden University with…

Promotor: M. Ubbink, Co-promotor: G. Siegal

The Center studies the social, legal and normative impact of emerging digital technologies.

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Robert Ietswaart does research into gene regulation at the famous Harvard Medical School in Boston. He developed an algorithm to better predict whether a candidate medicine is going to produce side effects. He studied mathematics and physics in Leiden, and gained his PhD in computational biology in…

This project’s aim is to critically assess current homicide data sources in order to develop a proposal for long-term EU-level monitoring of DRH.

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Analysis of drug adversity

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

The path to rational drug and dose selection

From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.

Source: Nature Biotechnology, Volume 2014, Issue June (2014)

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Rob van Wijk gave an interview on the role of zebrafish in drug discovery and development, published in FIGON’s journal Medicines as a preview of LACDR’s representation at the PhD competition during the Dutch Medicines Days (DMD). The entire interview can be read below.

High throughput microscopy

Over the past decade, several novel types of spatially resolved

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

An interdisciplinary and innovative research group combining History, underwater archaeology, GIS and wood provenancing methods.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

The Leiden Center for the Study of Ancient Arabia aims to promote research on the ancient languages and cultures of Arabia, and to disseminate this knowledge to the broader public.

TRIXY is a national Center of Expertise, in which clinical professionals and expert researchers work together to improve knowledge and clinical care for children with X and Y chromosome trisomies.

Promotor: B. van de Water

Immediately connect with the needs of industry with your master’s degree. The new course Practical Aspects of Quality Management in Pharma and Biotech provides just that. The LACDR and LUMC set up the course together with the Biotech Training Facility, located at the Leiden Bio Science Park. The first…

Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Promotor: M. Ubbink, Co-promotor: G. Siegal

The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.