242 search results for “breast center metastasis” in the Public website
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Unravelling cancer drug resistance mechanisms
Mechanisms fro drug resistance
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Leiden Healthy Society Center: making Leiden the healthiest city in the Netherlands
How can the people of Leiden age as well as possible? And what is needed to reduce health disparities? That is the mission of Leiden Healthy Society Center, a new partnership between the Municipality of Leiden, Leiden University and many other partners in the city.
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Refining individualized treatment in older patients with breast cancer
PhD defence
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Breaking barriers: unraveling response mechanisms to immunotherapy in breast cancer
PhD defence
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GLOBTAXGOV team meets Inter-American Center of Tax Administrations
On 15 March 2023, the GLOBTAXGOV team at Leiden Law School met with the Inter-American Center of Tax Administrations (CIAT) to explore opportunities for cooperation, to discuss the needs of tax administrations in the field of international taxation and evaluate ongoing projects and new initiatives where…
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Research
An overview of the research at the Cancer Dug Target Discovery group.
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Peter Bouwman
Science
r.j.p.bouwman@lacdr.leidenuniv.nl | +31 71 527 6105
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Pursuing new anti-cancer therapy as a team
Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Modelling metastatic melanoma in zebrafish
Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.
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Jan Kolen Director of LDE Center for Global Heritage and Development
Archaeologist Professor Jan Kolen has been appointed Director of the LDE Center for Global Heritage and Development (CGHD) with effect from 1 July 2013. This new inter-university heritage center is due to start in the autumn of 2013 within the framework of the strategic alliance between Leiden University,…
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Twentieth anniversary of the Lorentz Center: developing ideas in a scientific bubble
The 20th anniversary of the Lorentz Center will be celebrated on 28 June 2017 with the opening of an exhibition in the Oude UB. For two decades already, the Center has been a place of retreat for groups of international academics who want to explore a single issue.
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Working together in the Leiden Healthy Society Center: ‘It’s only when you make your research visible that you find each other'
As coordinator and lead promoter respectively of the Leiden Healthy Society Center, psychologists Sandra van Dijk and Anke Klein use interdisciplinary collaboration to resolve the major health problems of the present day. How are they going to do that in the coming period?
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Jeanette Satink visits the Beijing Children's Legal Aid and Research Center
At the end of March Jeanette Satink visited the Beijing Children's Legal Aid and Research Center.
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Research Presentation Wico Breimer 13 December @ 11:00 hrs, Gorter Center, LUMC
The project has been done in the High field MRI and clinical applications department under the supervision of Prof.dr. Andrew Webb. The title of the presentation is: ''Developing an Open Source Budget-MRI Using Permanent Magnets.
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traveled to Berkeley, California for the Annual Convention of Austria Centers
The fifteenth Annual Convention of Austria Centers took place in Berkeley, California, USA in May 2023.
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KNAW grant awarded for ‘People-centered constitutional law’ research project
Recently, Wim Voermans, Professor of Constitutional and Administrative Law, and Jaroslaw Kantorowicz, Assistant Professor at the Institute of Security and Global Affairs and a research associate at the Department of Economics, were awarded a grant from the KNAW Statesman Thorbecke Fund. This grant will…
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Drug Discovery & Safety
In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.
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Cancer Drug Target Discovery
In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…
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‘Science Based Rules on Plastic: Regulating Plastic Pollution’ at Lorentz Center
From 27 to 31 January, a workshop on the regulation of plastic pollution based on scientific evidence will be held at the Lorentz Center in Leiden.
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programme International Children’s Rights visit Dutch juvenile detention center De Hunnerberg
On 25 October 2017, the current class of students of the advanced LL.M. programme International Children’s Rights visited juvenile detention center ‘De Hunnerberg’ in Nijmegen (the Netherlands).
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BRCA1-associated breast cancer: finding new weapons for an old villain
PhD defence
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
PhD defence
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Immunosuppression in breast cancer: a closer look at regulatory T cells
PhD defence
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Research
An overview of the research at the Biologics Formulation group
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A community effort to assess and improve drug sensitivity prediction algorithms
Source: Nature Biotechnology, Volume 2014, Issue June (2014)
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It began with William of Orange
Leiden University was founded in 1575, thanks to William of Orange. According to tradition, he founded the University to reward the citizens of Leiden for their resistance to the Spanish occupiers.
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Computational modeling of cellular dynamics in tumor cell migration
Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.
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Visualization of Vitamin A Metabolism
Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.
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Delegation from Czech research center visits Leiden’s Faculty of Science
On 3 and 4 June 2015 a delegation from the biotechnology and biomedicine center in Prague (BIOCEV) visited the Faculty of Science in Leiden, as well as the Netherlands Centre for Electron Microscopy (NeCEN). The delegation was interested to see the potential for collaboration in the field of cryo transmission…
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How metastatic tumours manipulate their environment
Tumours act like mini-organs, manipulating their environment and using bodily processes to survive and metastasise. Through research by Erik Danen and his colleagues, we are learning more about the complex nature of tumour cells. In the Dutch newspaper NRC, the scientists discuss their findings.
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or writing assignment? You’re welcome to ask the Humanities Writing Center for help
Academic writing: it’s something that all students have to face. And it can be really quite difficult. The writing coaches at the Humanities Writing Center will therefore support you at every stage of your studies.
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Vasiliki Kosta appointed Emile Noël Fellow at the Jean Monnet Center of New York University (NYU) School of Law
Vasiliki Kosta has been appointed Emile Noël Fellow at the Jean Monnet Center of New York University (NYU) School of Law after a competitive selection process.
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Topic: The placebo and nocebo effects of communication
We study how communication can heal and harm when patients are confronted with an illness. Most of our studies focus on serious illnesses such as advanced cancer. Communication lies at the heart of medicine, yet we do not always know which specific communication helps patients. Moreover, many complaints…
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Kinetics for drug discovery – The first step towards an improved drug discovery paradigm
Supervisor: Indira Nederpelt
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4D Picture project
Helping cancer patients with treatment choices.
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Key publications
Key publications of the Cancer Drug Target Discovery group
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Swifties in PowNed video could take broadcaster to court
A controversial video in which PowNed asks Taylor Swift fans how far they would go for a meet-and-greet with the singer violates portrait rights according to Jeroen ten Voorde in Dutch newspaper ‘NRC’.
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Cell Systems and Drug Safety
The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…
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Bob van de Water
Science
water_b@lacdr.leidenuniv.nl | +31 71 527 6223
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Third annual conference of the Leiden Center for East African Law at Strathmore University, Nairobi
On the 27th April 2017, the third annual conference of the Leiden Center for East African Law (LEAC) took place at Strathmore University in Nairobi, Kenya. The theme of the conference was ‘East African Law: A Common Market, Opportunities and Challenges for the Business Community’.
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Work-in-Progress seminar at the Center of Multimodal and Audio-Visual Methods (ReCNTR)
Team ReCNTR gives feedback on the Food Citizens? I-doc
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PhD student becomes headwind cycling champion: ‘Just put your chin over the handlebars and pound the pedals’
With a headwind of 80 kilometres per hour, pouring rain and freezing temperatures, Jurjun van der Velde cycles down the Oosterscheldekering. On his traditional Dutch bike with back pedal brake, he is the second PhD student from the faculty to win the title.
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Healthy ageing
The elderly accept may minor discomforts like stiffer muscles and getting tired more quickly, but they do want to go to their children's birthdays independently. Preventive elderly care helps people with that. The goal is to let people grow old while maintaining their self-reliance and independence…
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New zebrafish study to understand human cancer
Ewa Snaar-Jagalska, Shuning He and colleagues from IBL, LION and LACDR reported on a new zebrafish study to understand micrometastasis of human cancer cells. They discovered a novel role for neutrophils in assisting metastasis formation, which provides critical insights for anti-cancer therapies.
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Molecular Pharmacology
In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…
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‘Building bridges between scientists: that's what we're good at’
Two directors. Both professors of mathematics, but one of them is a biologist. One comes, and the other goes. Roeland Merks will succeed Arjen Doelman as director of the Lorentz Center in September. What has been accomplished and what are the plans? And above all, what makes the Lorentz Center so un…
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Kosta speaks ‘on the principle of proportionality in EU law’ at the Center for Political and Constitutional Studies, Madrid (Centro de Estudios
Vasiliki Kosta participated in the García Pelayo Seminar of the Center for Political and Constitutional Studies, Madrid entitled: ‘Discretionary Powers and Judicial Review: What Destiny for the Principle of Proportionality?’
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Photosynthetic light reactions at the gold interface
Promotor: Prof.dr. T.J. Aartsma, Co-promotor: R.N. Frese
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Successful second annual conference of the Leiden Center for East African Law at the EAC headquarters in Arusha
On the 5th of May 2016, the second annual conference of the Leiden Center for East African Law (LEAC) took place at the East African Community headquarters in Arusha, Tanzania. The Conference was organized on the occasion of Europe Day with the generous support of the EAC, the EU delegation to EAC and…