1,037 search results for “biological come” in the Public website
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Mood variability during adolescent development and its relation to sleep and brain development
During adolescence, mood disorder onset peaks. Mood variability is associated with negative mental health outcomes, so understanding biological factors that might be associated with mood variability, such as sleep and structural brain development, could elucidate the mechanisms underlying mood and anxiety…
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Towards automated identification of metabolites using mass spectral trees
Promotor: Prof.dr. T. Hankemeier, Co-promotor: Dr. Theo Reijmers
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Bacterial glycomimetics: synthesis and applications
This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.
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Thiosugars: reactivity, methodology and applications
Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…
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Coiled-coils on lipid membranes: a new perspective on membrane fusion
Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros
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Histone-DNA assemblies in archaea. Shaping the genome on the edge of life
All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).
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Weathering the Ice Age
Where did species survive the cold cycles of the current Ice Age?
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Key publications
Key publications of the Biologics Formulation group
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Synthetic Study on ADP-ribosylation
This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.
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Giant barrel sponges in diverse habitats: a story about the metabolome
Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.
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In silico characterization of a GPCR focused library
Supervisor: Gerard van Westen
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Rudaz Serge
School of pharmaceutical sciences, University of Geneva - Switzerland
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Lipid signaling and inflammation: metabolomics for better diagnosis and treatment strategy
Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…
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Alvaro Viljoen
Professor at the Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria - South Africa
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Target Discovery
The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken
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Bioactivity based quality control for Chinese herbal medicine
Can we establish a new quality control system for herbal medicines that is based on bioactivity rather than a few abundant chemicals?
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Applications of Natural Deep Eutectic Solvents to Extraction and Preservation of Biomolecules
The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.
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Career prospects
The Biological- and Soft-Matter Physics specialisation is an excellent preparation for pursuing a PhD degree in physics.
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Research
Biotherapeutics or biologics, such as proteins, peptides, and nucleic acids, comprise an increasing share of the pharmaceutical market, whilst offering new therapies for difficult-to-treat diseases. Most notable is their contribution to the vaccination efforts during the COVID-19 pandemic. In most cases,…
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LED3 Lecture: Controlling Biological Function with Synthetic Photoswitches
Lecture
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Van Marum Colloquium: Biologically Inspired Catalytic Systems for Solar-to-Fuel Technologies
Lecture
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Breakthrough artificial photosynthesis comes closer
Imagine we could do what green plants can do: photosynthesis. Then we could satisfy our enormous energy needs with deep-green hydrogen and climate-neutral biodiesel. Scientists have been working on this for decades. Chemist Chengyu Liu will receive his doctorate on 8 June for yet another step that brings…
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The whole world comes together in Leiden
Under a typically grey sky, more than 1,300 international students gather around the mentors with their numbered signposts. It is the start of the Orientation Week Leiden: the introduction week specially for international students at Leiden University.
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Come to the Tour of Asia festival!
From gay rights in Asia to water management in the Philippines and from the Silk Road to current tensions with North Korea. Come to the Tour of Asia on 14 September to find out all you wanted to know about Asia and more.
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LIC Lecture: Biological applications of anion-selective transmembrane carriers
Lecture
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Archaeologists come up with a more precise estimate for how long modern humans and Neanderthals co-existed
Modern humans and Neanderthals may have co-existed in France and Northern Spain for up to 2,900 years until the Neanderthals disappeared. This is what archaeologists from Leiden University and Cambridge University write in a new publication in Scientific Reports.
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Coming soon: new sports and examination centre
A sustainable building that is both sports and examination centre. In September, a design team including architect Atelier PRO will begin to develop the plans for the new University Sports Centre (USC). Construction will begin in 2021, and the building is expected to be completed before September 2022.…
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Science Communication and Society
The research group Science Communication and Society has been physically within the Institute of Biology (IBL) since 2012 and has become a formal part of the institute in 2018. The mission of this group is understanding how science communication works to improve the interaction between science and s…
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Understanding functional dynamics and conformational stability of beta-glycosidases
Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Combined LC/MS-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes
Ceramides (CERs), cholesterol, and free fatty acids (FFAs) are the main lipid classes in human stratum corneum (SC, outermost skin layer), but no studies report on the detailed analysis of these classes in a single platform.
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Discoveries in 2023
From nanoparticles to colliding ice planets and from biological origami to new x-ray scanner techniques: this year again, our scientists have made wonderful discoveries. From the largest numbers to the smallest molecules and from the oldest galaxies up to the latest algorithms, take a look at each institute's…
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NeCEN
With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…
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Research
Within the Chinese medicine, more than 80% of the constituents of the preparations are derived from plants. Like any other organism, plants are constantly interacting with their changing and often harsh environment during the various phases of their life cycle.
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Overview
Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Shape Analysis for Phenotype Characterisation from High-throughput Imaging
We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.
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Theoretical Physics
In the spirit of 'unity in diversity', our objective is to promote insight into and appreciation for the wonder that the same physical laws and mathematical concepts apply to the whole of nature, from the largest to the smallest energy and length scales. We strive for the application of abstract theoretical…
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Molecular, Cellular and Organismal Biology (MSc)
The master's specialisation Molecular, Cellular and Organismal Biology at Leiden University examines the molecular mechanisms underlying health and disease and how cells and organisms adapt to environmental factors.
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Library comes up with creative solutions
UBL, Leiden University Libraries, is doing all it can to continue to offer its services. Even now the motto is, ‘work from home’. Who is doing want and how are things going?
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More efficient learning thanks to sleep
Young children, adolescents and students may experience learning difficulties as a result of lack of sleep. Dr Kristiaan van der Heijden investigates sleep problems and solutions for various age groups.
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Over fifty scientists come together for MACODA
In the week of 16 – 21 September, an international group of more than 50 scientists met at the Many Criteria Optimization and Decision Analysis (MACODA) workshop. They discussed many-criteria optimization, which is the searching for optimal solutions when one has to consider a larger number of criteria.…
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Heineken Young Scientists Award for three Leiden researchers
Three of the four Heineken Young Scientists Awards for 2022 have gone to researchers from Leiden: chronobiologist Laura Kervezee, physicist Jordi Tura i Brugués and health psychologist Liesbeth van Vliet.
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Why not sing? Reconstructing the evolution of female and male bird song
Female and male songbirds sing equally elaborate songs in some species, but in others, females do not sing like males or not at all. How did such pronounced differences in male and female communication evolve?