Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Throughout your 3-year Security Studies programme you explore the effects of events (such as war or natural disaster), understand them via relevant academic perspectives, and actively design strategies and solutions to resulting security challenges.

Throughout your 3-year Science for Sustainable Societies programme, you will learn about the importance of analysing complex sustainability challenges using an interdisciplinary perspective.

Leiden chemists have proposed a new model for enzymatic reactions, in which the flexibility of the substrate is much more important than previously thought. Their results are paradigm-shifting and could have major implications for drug research and enzyme engineering. Publication in Angewandte Chemi…

Laura Heitman of the Leiden Academic Center for Drug Research (LACDR) has been nominated for the Prix Galien Research Award. This important pharmaceutical prize honors young, prominent researchers whose scientific research is of great importance for fundamental or clinical drug research.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

The Sport Data Center (SDC) consists of the data science disciplines of Leiden University and Technical University Delft, combined with the sport science branches of the Amsterdam Institute for Sport Science and the Sport Engineering Institute of the Technical University of Delft.

The research program of the QO group has three leading themes: Optical Physics, Quantum Optics, and Photon-Matter Interactions. We work mostly at the boundaries between these themes with entanglement as a bridging and binding agent.

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

Promotor: Prof.dr. M. Ubbink

What are the essential determinants of (dis)trust? And, what are the effects of being (dis)trusted?

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Can cyclic peptides provide a new generation of antibiotics?

This book is an examination of why and how the elective principle, already established in Transylvanian and Polish political culture in the late medieval period, was transformed in the early elections of the 1570s.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Why obey the state? Dorota Mokrosińska presents a fresh analysis of the most influential theories of political obligation and develops a novel approach to this foundational problem of political philosophy, an intriguing combination of the elements of natural duty and associative theories.

The mission in this division, headed by Laura Heitman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

While it has traditionally been seen as a means of documenting an external reality or expressing an internal feeling, photography is now capable of actualizing never-existed pasts and never-lived experiences.

On Thursday 10 November, the GTGC organized a research seminar. During this seminar Saori Katada presented her paper on Regional Approach to Financial Statecraft: Japan and India in the Face of Rising China.

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

As part of your application procedure for the bachelor’s programme English Language and Culture, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations. You will also…

As part of your application procedure for the bachelor’s programme Philosophy: Global and Comparative Perspectives, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations.…

As part of your application procedure for the bachelor’s programme Arts, Media and Society, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations. You will also answer…

As part of your application procedure for the bachelor’s programme Linguistics, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations. You will also answer a number…

A list with keywords and all the information you need in your first year. Click on the links and read more about the subjects you want to learn more about.

The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

PhD defence

As part of your application procedure for the bachelor’s programme Archaeology, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations. You will also answer a number…

As part of your application procedure for the bachelor’s programme Archaeology, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations. You will also answer a number…

As part of your application procedure for the bachelor’s programme Archaeology, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations. You will also answer a number…

Promotor: W. Jiskoot, Co-promotor: H.A. Every

Promotor: A.P. IJzerman

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

On 11 November 2021, Evelien Campfens defended the thesis 'Cross-border Claims to Cultural Objects'. The doctoral research was supervised by Prof. N.J. Schrijver and Prof. W.J. Veraart (VU Amsterdam).

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

This volume explores the nature of ellipsis, the core phenomenon that results in various types of omission in sentences.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).