In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

We study the physics of a broad range of biological and soft materials

The Plant BioDynamics Lab (PBDL) is a laboratory dedicated to experiments designed to develop and validate quantitative mathematical models of dynamical processes in biology. The principal objective of developing these models is to make quantitative predictions about these processes.

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Dr. Theo Reijmers

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

The China Region Group develops and monitors Leiden University's cooperation with China. It is chaired by the Dean of the Faculty of Science, Prof. Jasper Knoester, and consists of representatives of Leiden University's faculties and various policy departments.

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

This book examines the role of memory in animation, as well as the ways in which the medium of animation can function as a technology of remembering and forgetting. By doing so, it establishes a platform for the cross-fertilization between the burgeoning fields of animation studies and memory studie…

TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.

The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…

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The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

FIJI is one of the most used image analysis tools in the world. FIJI stands for FIJI is just ImageJ, it is however much more.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

This project is part of the Next Generation ImmunoDermatology (NGID) consortium, which focuses on the comprehensive phenotyping of six different immune-mediated inflammatory skin conditions. A common factor contributing to these diseases is a dysfunctional skin barrier. The skin barrier function is…

Medical Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University. The section is headed by Prof. Dr. Hans Aerts.

If you wish to know exactly what is going on in a healthy or sick human body, and at various levels such as molecule, cell, tissue, organ, larger systems and a person as a whole? Do you wish to learn how to do research which contributes to diagnoses, treatment and prevention of diseases? Then the bachelor…

The two-year Bioinformatics programme (120 EC) includes mandatory core courses and electives, as well as a Master's Thesis Research Project.

PhD defence

Dr. Eduard Fosch-Villaronga from eLaw collaborates with researchers from the Indraprastha Institute of Information Technology Delhi (IIIT-Delhi) and University of Delhi (DU) in an effort to explore and reflect upon the potential legal, ethical and pedagogical challenges of deploying a social robot in…

What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?

Conference

Lecture, Public Lecture

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

Nico Schrijver professor emeritus in Public Law and State councillor at the Council of State has been appointed by the European Union and the United Kingdom as a member of the Arbitration Panel which is authorised to settle disputes on the EU-UK Withdrawal Agreement.

The second quantum revolution is in full swing, bringing all kinds of new technologies to within reach, and offering many opportunities as well as challenges. Leiden and Delft decided to join forces.

Dr Bela Bode receives a Feodor Lynen research fellowship for postdoctoral researchers by the Alexander von Humboldt-Foundation for development of new methods for signal enhancement in solid state NMR. He aims to create a specific analytical tool for surface studies and research on membranes and membrane…

PhD defence

PhD defence

Promotores: Prof.dr. D. Bouwmeester, Prof.dr. A. Fiore (TU Eindhoven)

Better pay and new agreements with streaming platforms: the actors’ strike that brought Hollywood to a standstill a few days ago is mainly about money. But there is something else that film actors are worried about: the increasing use of Artificial Intelligence. Is this fear justified?

Antwoord op veelgestelde vragen over onderzoek met proefdieren bij de Universiteit Leiden. FAQ

PhD defence

Many of the challenges of our time are too complex to be resolved within the confines of a single discipline. Leiden University is a broad-based university where an incredible number of research fields converge. That makes us the ideal breeding ground for, and practitioners of, interdisciplinary research…

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

This book rovides an economic history of Portugal over the course of eight centuries, from 1143 through to 2010 and situates Portugal's economic growth within the context of European development. It also responds to fundamental questions about when, how and why the economy expanded, stagnated or co…

Starting your PhD during two major crisis in your country; it happened to Kamaran Palani, PhD student at the Dual PhD Centre and ISGA who lives in Erbil, the capital of the Kurdistan Region of Iraq. In spite of the difficulties in his county, Palani (34) stuck to his PhD-research about the fluidity…

The United States and the European Union need to work together more closely in the field of the law to fight terrorists and criminals who are operating increasingly internationally. This was the advice given by American Minister of Justice Loretta Lynch during her visit to Leiden University on 1 Jun…

The project’s main aim was to build a reconstruction of a prehistoric house plan, without using any metal tools. How effective are tools made of stone, flint, bone, antler and wood? What are the constraints imposed by the various building materials? How much labour do we need and how much knowledge…

PhD defence