This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

On the 26th of September, Cosmas Rai Amenorvi successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Cosmas on this achievement!

Natashe Lemos Dekker addresses the experiences of family members of people with dementia as they expressed their sense of gradually losing the person with dementia in the article 'Anticipatory Grief in Dementia: An Ethnographic Study of Loss and Connection' published in Culture, Medicine, and Psychi…

Lecture

The topic of this PhD thesis is teachers' perspectives on self-regulated learning.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

This dissertation defends the existence of a type of movement that has so far been considered not to be possible, namely, movement of a bare head to a specifier position over arbitrarily long distances.

On Wednesday 31 August 2022, the graduation ceremony of the BSc Security Studies took place. The ceremony was opened by programme director Daan Weggemans.

This study discusses the position of the monasteries in pre-1950s Tibetan societies and how that position was informed by Buddhist monastic ideology.

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

This project aims to develop advanced data analysis methods for monitoring and increasing our understanding on biodiversity dynamics in nature reserves such as the Oostvaardersplassen.

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

Leiden University is home to over a hundred specialists studying the Middle Ages and the Early Modern period. From 2017-2018 onwards, they will join forces to offer two new options for specialisation within existing MA programmes: Medieval Studies and Early Modern Studies.

Can SMILE, our multi-component intervention, which combines cognitive-behavioural therapy for insomnia, mindfulness, stress, and lifestyle components, improve sleep quality? Can it also improve mood and quality of life and prevent depression and anxiety in the long term?

A Spatial Enquiry into the Urban Society of Rome’s Imperial Port-Town

This edited volume provides a synthesis on the question of business attitudes towards and its influence over the development of the modern welfare state. It gathers leading scholars in the field to offer both in-depth historical country case studies and comparative chapters that discuss contemporary…

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: H.M. Cuppen, S. Ioppolo

How can we quantify the density of species within a community through environmental DNA concentrations?

Through a range of case studies spanning the post-Cold War period in Iraq, Moldova and Serbia, this book studies asymmetric conflicts where warring sides exhibit vast power differentials.

The Board of Governors of Leiden University has confirmed the appointment of Professor André Gerrits (Institute for History, currently in the field of Russian Politics and History) to the field of International Studies and Global Politics, commencing October 1st 2015.

This doctoral thesis comprises four studies on the content and structure of physics teachers’ belief systems about teaching and learning physics in secondary education in the Netherlands.

Voormalig demissionair staatssecretaris van Fiscaliteit en Belastingdienst Marnix van Rij gaf op 17 juni in samenwerking met universitair docent Esther Huiskers-Stoop een gastcollege over belastingrecht en duurzaamheid. Deze lezing werd op initiatief van student Darya de Wilt georganiseerd.

Conference, Workshop

This research investigates everyday lives and workplace experiences of Iranian workers employed at textile industry, which was the second biggest industry after oil following the latter’s discovery in 1908.

The urban graveyard presents several studies in which the results of older archaeological and osteoarchaeological research are compared to more recent excavation data from several Dutch, Belgian and Danish cities and towns.

On March 31st – April 1st, the Association for the Study of Law, Culture and the Humanities (ASLHC) will hold its twentieth annual conference at Stanford Law School.

A framework for prospective/ex-ante life cycle assessment (LCA) and ecological risk assessment (ERA) of emerging technologies is developed and applied to a case study of III-V/silicon photovoltaic panels.

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

The starting hypothesis of the project is that secrecy is not always inimical to democratic governance as conventional wisdom has it.

Tin electrodeposition applications have rapidly evolved in the past 25 years.