The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

On this page, you will find the recordings of the online This Week's Discoveries from May 12, 2020, as well as a list of speakers since October 2015.

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Dr. at Max Planck Institute for chemical Ecology, Jena - Germany

Designing and synthesizing high-affinity ligands for a given drug target have always been among the more important challenges in the drug discovery process.

The current resurgence of whooping cough is alarming, and improved pertussis vaccines are thought to offer a solution. Outer membrane vesicle vaccines (omvPV) are potential vaccine candidates, but omvPV-induced humoral responses have not yet been characterized in detail.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

How are the epidermal lipid pathways involved in health and disease.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

On Tuesday 11 February, the European Data Protection Supervisor, Mr. Wojciech Wiewiórowski, visited eLaw, - center for Law and Digital Technologies at Leiden Law School to give a lecture on facial recognition systems and data protection in Europe.

Lecture

Dr Mark Leiser, Assistant Professor in Law and Digital technologies at eLaw, has been appointed an International Research fellow at the Coordinated Research Center in Information Society and Law of the University of Milan in Italy. The aim of the Center is to conduct research on issues related to the…

From filtering UV light in sun cream to preventing perspiration odour in socks and sterilising fridges and washing machines. The use of nanoparticles in products is increasing. But what is the impact of these miniscule particles on the environment?

For 20 years, Comenius has been affiliated with the University of Groningen and organizes courses - both nationally and internationally - around personal leadership. The Comenius Courses are designed for experienced directors and managers from the public and private sectors such as general managers…

From 14 to 15 September 2023, Simona Demkova, AI researcher at the Europa Institute, participated in the INDIGO Project Final Conference, where she provided valuable perspectives on the implications of AI for European public law.

Technology and privacy, trust and mistrust. A discussion about this broke out when the University installed scanners and students protested. On Wednesday 2 February experts from Leiden University will explore this topic at the eponymous symposium. We called Roy de Kleijn, as a computer scientist and…

Lecture

The Netherlands has DigiD, Portugal ‘de Cartão de Cidadão’, and Ireland MyGovID. Europe now wants one uniform digital identity card - the same for all Member States. For the Dutch government, the European successor to DigiD is a prestige project. State Secretary Van Huffelen wants to roll out an app…

Europe is working full steam towards a digital identity for every EU citizen. And although it might be really useful to be able to hire a car everywhere in the EU with no hassles, Bart Custers, Professor of Law and Data Science at eLaw, the Center for Law and Digital Technologies, sees many loose ends.…

On Tuesday 8 November, Americans will go to the polls for the so-called midterm elections. 'We tend to look at this election as if it were a poll on Biden. But it’s not a presidential election,' emphasises associate professor Sara Polak.

PhD defence

How do you offer high-quality and interesting education with simple means? Universe Awareness of Leiden University spoke about this during the annual science festival in Botswana. With among others a laser experiment compiled of household materials, they showed the possibilities to interest young people…

After four years of hard work, the time has finally come: your thesis is finished. But who of your family and friends will ever read it? Biologist Lizah van der Aart decided to make a magazine for layman. 'It was precisely the explanation of the difficult, fundamental parts that gave me good tools for…

Maarten Aalbers was invited as a guest speaker by the University of Bergen (Norway) to present his views on the joint application of state aid law and free movement law concerning the adoption of sugar taxes.

Election Day is over, but it's by no means clear who the new President of the United States will be. On the morning after Election Day, US expert Sara Polak relects on the results that are in so far, and looks ahead to the coming days.

best phd theses of the faculty of science Leiden - physics, chemistry, computer science, biopharmaceutical sciences, biology, industrial ecology, environmental sciences, astronomy, mathematics

The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.

Former PhD, Bachelor and Master students of the Van Exter Lab

A neural network mimics how our brain works. Evolutionary algorithms use the principle of natural selection to solve complex problems. This kind of 'natural computing' is being used to improve the diagnosis of Parkinson's disease or the production of steel.

The infectious diseases malaria and tuberculosis are responsible for 2.1 million deaths every year. Leiden researchers are currently testing a new tuberculosis vaccine.

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Life Sciences Artificial Intelligence Data Science

Multiple Sclerosis, Parkinson’s and Alzheimer’s disease are the most common neurodegenerative disorders. Unfortunately, no effective treatments are currently available to halt the progression of these neuroinflammatory diseases [1].

To be eligible for Molecular, Cellular and Organismal Biology at Leiden University, you must meet the following admission requirements.

A novel in vivo model system for studies on glucocorticoid resistance

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…