Our Division has created and maintains the Visualisation Core Facilities of the LACDR. This is a multi-user facility offering basic and advanced microscopic techniques to scientists of the LACDR.

What did we do over the past year? Well, we played quantum games, helped develop an instrument for the Extremely Large Telescope and started a new bachelor's programme. Oh, yeah, and we officially opened our brand new Gorlaeus Building! Warm up the fingers and get ready to click and scroll through…

What is your favourite thing about Leiden University?

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On 3 October, Leiden University is putting on a Science fair packed with stalls showcasing discoveries and scientific games.

Not experiments and lab coats, but computers and artificial intelligence: this year's Nobel Prize in Chemistry went to the inventors of the groundbreaking AI model, AlphaFold. This programme accurately predicts protein structures based on their genetic code—a crucial step in understanding biological…

No, this isn’t about a Star Wars Alliance that wants to suppress The Resistance. Rather, the EPIC Alliance brings together scientific experts from seven countries to address the growing threat of antibiotic resistance. Leiden professor Nathaniel Martin is part of the 11-member consortium.

Medical Delta has appointed seven professors who will bridge the medical worlds of Leiden, Delft and Rotterdam.

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

The group Statistical Science is responsible for research and teaching in statistics and data science.

With our research and teaching, we help make the world a better place. We join in the academic and public debate, and seek answers to economic and social issues – not just at the local and regional level but at the global one too.

The HOPES study is one of the largest investigations of this kind to date! By studying existing brain scans and data collected form over 4,000 14-25 year olds, the project team hopes to identify specific changes in the brain that make young people vulnerable to suicidal thoughts and behaviours.

To be able to identify, slow down and reverse functional deterioration in the elderly to give them more years of good health.

Data scientist Lindsey Burggraaff has won the second edition of the Krijn Rietveld Memorial Innovation Award. She receives the prize for her research into bioactive substances in food. ‘Burggraaff's work is situated at a unique intersection of data science, biochemistry and the fields of food and nutrition,’…

The Dutch X-omics Initiative has received seventeen million euros from NWO as part of the National Roadmap for Large-Scale Infrastructure. Leiden University’s metabolomics research led by Thomas Hankemeier is one of the participators.

Two excellent young chemists, Jeroen Codée and Sander van Kasteren, have received an ECHO grant for €260,000 from the Netherlands Organisation for Scientific Research (NWO). This funding will allow them to begin their research projects.

A team of surgeons at Leiden University Medical Center and the Centre for Human Drug Research have removed a lung tumour that they pinpointed using fluorescence. This is the first time that this technique has been used in Europe in a patient with a lung tumour.

The Metabolomics Facility of Leiden University is now officially in operation to prevent disease and to improve health throughout the human lifespan.

The prestigious journal Science Translational Medicine has published a study by researchers from the Institute of Biology Leiden (IBL) on a potent new antibiotic that can overcome resistance. ‘The idea was to tweak the original antibiotic and create a next-generation drug’, says Nathaniel Martin, professor…

An overview of awards and prizes granted to our staff and students in 2020, as well as special appointments at Leiden University and other institutions.

Leiden scientists are the main applicants for five projects that have been awarded a Science Groot grant of up to 3 million euros in the Science Domain. In addition, several Leiden scientists are involved in other projects that have been awarded funding.

As of 1 March 2018, Elizabeth (Liesbeth) de Lange has been appointed as Professor of Predictive pharmacology at the Leiden Academic Centre for Drug Research (LACDR). She is head of the research group Predictive Pharmacology and mainly aims at developing mathematical models that can predict the effect…

Before patients can take a pill, scientists often spend years in the lab developing and testing a candidate drug. That often includes experiments with laboratory animals. As head of the rodent facility, Ilze Bot and her colleagues ensure that these experiments are conducted in an ethically responsible…

Fourteen promising researchers from Leiden University have been given the opportunity to realise their research plans for the coming years thanks to a Veni grant from the NWO. This year, these subsidies have been granted to studies of the influence of noise on the great tit, the conditions necessary…

Unraveling the immune-suppressive actions of drugs like prednisone.

We know this, but we don’t act on it: eat healthily, move more, address our stress levels and sleep well. Internist and Professor of Diabetology Hanno Pijl is fascinated by the effect that a healthy lifestyle can have on health. He researches how this lifestyle is achievable and satisfying, for patients…

In the future, physicians may be able to identify dementia much earlier than they can today because a computer algorithm will be able to predict from brain scans how our memory is going to develop.

At Leiden Bio Science Park (LBSP) Leiden University works together with the business community, the LUMC and the Municipality of Leiden.

Medicines do not follow the one size fits all principle, because genetic differences can influence their efficiency. That is what research by PhD candidate Julia Hillger shows. She defends her PhD dissertation Take it Personal on Thursday 7 December.

Four Leiden researchers, who have recently obtained their PhDs, will receive a Rubicon Grant from NWO to conduct research abroad. A total of 22 scientists have received Rubicon Grants. This grant aims to provide young, promising scientists with international research experience.

The focus of this programme is the inter-community social relationships and transformations of island networks in the Lesser Antilles across the historical divide.

From the Republic of Moldova to Italy and from Indonesia to Greece, students from all over the world participated in the Bio-Pharmaceutical Science Summer School 2017. The students got a comprehensive overview of the education and research performed within the LACDR. ‘I am very happy to be here,’ says…

Can we make a better vancomycin?

An overview of our infrastructure at the SPP division:

In what way can new tools and techniques be used to develop drug candidates for the treatment of neurological disorders?

The imaging group focuses on bio-imaging, image analysis and visualization.

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

How can the development of constrictions in the blood vessels be reversed?

With a headwind of 80 kilometres per hour, pouring rain and freezing temperatures, Jurjun van der Velde cycles down the Oosterscheldekering. On his traditional Dutch bike with back pedal brake, he is the second PhD student from the faculty to win the title.

The Leiden Institute of Advanced Computer Science (LIACS) is a proud member of the NExt ApplicationS of Quantum Computing (NEASQC) consortium, which recently received an ERC H2020 grant to stimulate the state-of-the-art in industrial quantum computing. LIACS contributes research and development of new…

Increasing resistance and a lack of new antibiotics are a serious problem for public health. Against this background, Gilles van Wezel of the Institute of Biology Leiden is looking for new medicines. Together with former PhD student Changsheng Wu and colleagues he discovered the special antibiotic lugdunomycin,…

PhD defence

In honour of Krijn Rietveld (1956 - 2018), Leiden University Fund and dsm-firmenich have created the Krijn Rietveld Memorial Awards to reward researchers who make extraordinary efforts to bring about an impact beyond scientific understanding in the field of life sciences, health science, biotech, or…