1,851 search results for “state cell technology” in the Public website
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therapies for mitochondrial cardiomyopathies using advanced human stem cell models
PhD defence
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Quest for the cure: Towards Improving Hematopoietic stem cell based lentiviral gene therapy
PhD defence
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Spatio-temporal aspects of antigen cross-presentation in dendritic cells
PhD defence
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'Can computers judge court cases?'
Prof. Jaap van den Herik was a guest in the latest episode of the Nationale Data Podcast.
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Research
Research at the Macromolecular Biochemistry group is comprised of the following research themes:
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Formulation and Characterization of Vaccines
Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…
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Deep imaging
A computer can look at, and learn from, many more images than a human specialist. AI systems are rapidly becoming indispensable for medical and biological applications. But they still have to learn how to explain their decisions.
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Joan van der Waals colloquium
The Joan van der Waals colloquium is an ongoing bi-weekly lecture series.
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Janneke Wesseling on The Device Paradigm and Contemporary Practices in Art and Design
On May 18 Janneke Wesseling gave a lecture at the conference
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Cryotomographic visualization of symbiosis initiation in the Euprymna scolopes-Vibrio fischeri association
The overall aim of this project is to understand, on the molecular level, how the bacterium V. fischeri cells interacts with their squid host.
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Kraft Lab - Self-assembly in Biological and Soft Matter
Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.
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FishForPharma: Training network on zebrafish infection models for pharmaceutical screens
How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?
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Vision and Imaging
On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…
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Allosterism
The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…
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Leiden Institute of Physics
Physicists at the Leiden Institute of Physics (LION) conduct fundamental research into physical phenomena. They are inspired by curiosity and the desire to know more about the world in which we live. This research has always paved the way for new practical applications. These are something that the…
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Imaging and Bioinformatics
On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…
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Research
Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…
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Sheathless capillary electrophoresis-mass spectrometry as a new approach for analyzing the polar metabolome
Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.
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Research
Combining different disciplines, researchers work together to formulate innovative solutions to societal problems.
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Education
Education & outreach
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Biophysical Organic Chemistry
The long term goal of the Biophysical Organic Chemistry/SSNMR group, headed by Prof. Huub de Groot, is to reach an understanding of structure, dynamics and functional mechanisms of membrane proteins and self-organized biological assemblies and to translate this knowledge into new concepts for nano-devices,…
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Functions of autophagy in the filamentous fungus Aspergillus niger
What are the functions of autophagy in the filamentous fungus Aspergillus niger?
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Biology (MSc)
The master’s programme Biology at Leiden University offers seven specialisations ranging from Cell Biology to Molecular Genetics. The programme prepares you for a career in research within or outside academia.
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Institute of Biology
Nature is a never-ending source of inspiration for the researchers at the Institute of Biology Leiden (IBL). Based on a better fundamental understanding of nature, they are able to seek solutions in the area of health and biodiversity. The theme of IBL is ‘Harnessing biodiversity for health.’
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Bioactive Molecules in Microbial Sciences
Microbial Sciences' contribution to the Bioactive Molecules research theme is to discover new bioactive molecules and enzymes and unravel their mechanisms of action, regulatory networks, and the (bio)synthetic pathways required for their production.
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Novel immunomodulatory drugs for tuberculosis treatment
Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?
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Bart Custers in De Jurist on UBO register and privacy legislation
Ultimate beneficial owners (UBOs) of companies should have registered their information in the Dutch UBO register before 27 March 2022. The Dutch Minister of Finance saw no reason to postpone the deadline for registration, according to answers to parliamentary questions. In an article on the legal platform…
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Simona Demková discusses the EU’s human-centred approach to regulating artificial intelligence
On 27 and 28 April, Simona Demková participated as a panelist at the conference 'A
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Visual analytics for spatially-resolved omics data at single cell resolution: Methods and Applications
PhD defence
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Supramolecular & Biomaterials Chemistry
The Supramolecular & Biomaterials Chemistry group comprises the PIs Alexander Kros, Roxanne Kieltyka, Gregory Schneider and Sander Wezenberg, and is active in the field of self-assembly of amphiphilic peptides and applying them in supramolecular chemistry.
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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Get to know Chemistry
The master's programme in Chemistry offers you access to cutting-edge research. This research is concentrated in two areas: Chemical Biology and Energy & Sustainability. Students in the research area Chemical Biology will study fundamental biological and biomedical problems to understand physiological…
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Key publications
Key publications of the Skin Barrier and Vaccination group.
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China Region Group
The China Region Group develops and monitors Leiden University's cooperation with China. It is chaired by the Dean of the Faculty of Science, Prof. Jasper Knoester, and consists of representatives of Leiden University's faculties and various policy departments.
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Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax
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Surface Temperature and the Dynamics of H2 on Cu(111)
Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…
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Understanding the uptake and internal distribution of metallic nanoparticles in Danio rerio larvae
The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.
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Enumeration and Simulation of Lattice Polymers as Models for Compact Biological Macromolecules
Promotores: H. Schiessel, G.T. Barkema
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Development of automatic image analysis methods for high-throughput and high-content screening
Promotor: B. van de Water, Co-Promotores: J.H.N. Meerman, F.J. Verbeek
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ADAPTED
The ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project is a major new initiative to investigate an area of Alzheimer's Disease (AD) research which has previously received little attention. The project aims to improve understanding of the function…
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'Q-wires': Synthesis, electrochemical properties and their application in electro-enzymology
An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.
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Research
The Department of Biophysical Structural Chemistry studies how biological systems work at the molecular level through high-resolution structural analysis. Using state-of-the-art techniques in structural biology such as cryo-electron microscopy and X-ray crystallography we gain crucial insights into…
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Nanomedicine to Visualize and Treat Inflammation after Stroke (NAVISTROKE)
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Structural changes in single chromatin fibers induced by tension and torsion
Promotor: Prof.dr. T. Schmidt, Co-promotor: Dr. ir. S. J.T. van Noort
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LACDR PhD Portal
The objective of the PhD Education and Supervision program is to educate PhD candidates in becoming professionals who are competent to conduct scientific research in the field of the pharmaceutical sciences independently.
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Inverse electron demand Diels-Alder pyridazine elimination: synthetic tools for chemical immunology
The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…
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Thiosugars: reactivity, methodology and applications
Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…
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PhD Course Microscopy
This is a yearly event where we move in one week from the physics of light through the composition of the microscope, fluorescence microscopy and end up with some image analysis All the lectures are backed by practicals to really put your obtained knowledge into practice
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Coiled-coil mediated liposomal fusion: Asymmetric behaving peptide fusogens
Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.
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Human skin equivalents: understanding the lipid biosynthesis in the skin
There is considerable need for improved skin models to develop safe and efficient drugs for skin delivery as well as for cosmetic and chemical product testing on the skin.