Drug development is a complex process in which many parties work together. Every day, the researchers at LACDR devote their energies to developing drugs that are new, better, more efficient and easier to produce. And thus to the millions of patients who know all too well why this research in Leiden…

The CADS Research Cluster People, Power and Diversity aims to further theoretical and methodological debates on the classifications of human difference, such as gender, race, ethnicity, sexuality, class, age, ability, religion, level of development, time, etc., and the way these classifications organize…

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

A next, general pharmacological problem to be tackled is how drug-target binding kinetics in vivo, affects target occupancy as an important indicator of the time-course of drug effects.

Why do some civil wars experience quagmire, a situation in which belligerents are trapped in fighting? To explain this puzzle, Jonah Schulhofer-Wohl (Leiden University Institute of Political Science) analyses the overlapping strategic interactions between foreign powers and the warring parties. Studying…

Lecture

Harm reduction in practice: a comparative analysis of the Dutch and Brazilian approach towards drug users.

Discovery of metastasis promoting candidate drug targets

Lecture

Lecture

In the track War and Peace Studies, you will gain a thorough understanding of the history, theories as well as the contemporary and future policy challenges related to war, warfare, and the multidimensional promotion of peace.

Lecture

In 1940 the Germany occupiers ordered the dismissal of all Jewish staff of the university. This resulted in protest speeches by fellow academics.

In Freedom on the Offensive, William Michael Schmidli illuminates how the Reagan administration's embrace of democracy promotion was a defining development in US foreign relations in the late twentieth century.

Cigdem Oguz defended her thesis on 13 June 2018

This book explores the lasting legacy of the controversial project by the Congress for Cultural Freedom, funded by the CIA, to promote Western culture and liberal values in the battle of ideas with global Communism during the Cold War.

Information about the situation in Ukraine

Teaching excellence is one of the core functions of the War, Peace and Justice (WPJ) research group. WPJ members engage in diverse forms of public engagement, but all share a commitment to education.

Despite the wealth of historical literature on the Second World War, the subject of religion and churches in occupied Europe has been undervalued.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Leiden University commemorates its victims of the war and pays tribute to all members of the university community who resisted injustice. Rudolph Cleveringa, for instance, the dean of the law faculty who gave a protest speech in 1940 after his Jewish colleagues were fired. We honour their memory through…

Drugs-related violence in Mexico is similar in terms of dynamics and strategy to the IS hybrid war in the West. This is the claim made by Teun Voeten. PhD defence 20 September.

Writing under Wartime Conditions is a study into North and South Korean literature written during the Korean War.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Science

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

On 1 September 2022 Güldeniz Kibris successfully defended a doctoral thesis and graduated.

How was anti-communism organized in the West? New volume edited by Giles Scott-Smith, Luc van Dongen and Stephanie Roulin on the aims, arguments and associations of a range of transnational anti-communist activists during the Cold War.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Although rarely considered by the pharmaceutical industry or clinicians, 24-hour rhythms in physiology are a factor of potential influence on the pharmacokinetics and pharmacodynamics of drugs.

Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

A new special issue on translation and the cultural Cold War sheds light on the understudied and yet important role of translation in cultural transfer.

The War, Peace and Justice group unites scholars and practitioners to explore war dynamics, peace promotion, and justice’s role in conflict and global affairs.

Studies on the Ottoman Jihad on the Centenary of Snouck Hurgronje's

How can we extend the drug residence time to combat diseases more effectively?

On 11 April 2018, students of the Advanced Master’s in European and International Human Rights Law attended a lecture on the human rights situation in Mexico. The lecture was delivered by Dr. Víctor Avendaño Porras, who lectures and researches at Mexico’s CRESUR (Research Centre on Teaching Formation…

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

During the course of drug discovery translational steps are made.

This thesis seeks to examine the emergence of Persian novels and short stories during the Iran-Iraq War (1980-1988).

Can effective synergists be identified to enhance the effect of antibiotics against Gram negative pathogens?

From Apartheid in South-Africa to 9/11 in the United States: there is not a single culture that is not shaped by the memory of war or conflict. The minor Cultural Memory of War and Conflict focuses on how such memory cultures influence and shape societies today.

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

Source: ChemMedChem (2015)

Heart failure is a major health care problem with high mortality.

On Wednesday 16 June 2021, Karim Khan was sworn in at the International Criminal Court (ICC) in The Hague. Experts say this is no easy time to join the ICC.

On the 6th of March 2023, Santino Regilme presented his work-in-progress titled 'Global Drug Wars: Contested Normative Orders of Peace, Security, and Human Rights'. If the battle against illegal drugs is construed as a war, how is victory in such a war defined and constructed? If the oppositional…

Data analysis with Python and R are rapidly becoming essential skills for modern scientists. Therefore, we are offering courses to develop your scientific computing skills. Those courses are optional for LACDR PhD candidates.

This volume provides an authoritative, cutting-edge resource on the characteristics of both technological and social change in warfare in the twenty-first century, and the challenges such change presents to international law.