333 search results for “vries outbreaks” in the Public website
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Better ligands for G Protein-Coupled Receptors
The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.
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Regulation of enzyme production in fungal cell factories
Our object is to identify and characterize transcription factors involved in lignocellulosic biomass degradation in the filamentous fungus Aspergillus niger.
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Soil Organic Amendments for Climate-Smart Agriculture
PhD defence
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Global metabolomics and lipidomics approaches to probe virus-host interactions
The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.
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Government Capacity, Societal Trust or Party Preferences? What Accounts for the Variety of National Policy Responses to the COVID-19 Pandemic
What Accounts for the Variety of National Policy Responses to the COVID-19 Pandemic in Europe?
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Key publications
Key publications of the Cardiovascular Pharmacology group
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The Sand Motor - Building with Nature to optimise coastal protection and other ecosystem services
How can mega sand nourishments, such as the Sand Motor, be designed and managed for optimal ecosystem services provision ?
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The Nature of the Workmen's Marks and Their Interaction with Writing
The project concerns the nature, the usages and functions of pictographic systems in relation to writing in societies with (restricted) literacy.
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Selectivity
Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.
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Non-take-up of social support and the implications for social policies
This dissertation takes an important step in understanding the phenomenon of non-take-up of social support and what it means for contemporary social policies.
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Medical Systems Biophysics and Bioengineering
The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.
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Evaluation of (4-Arylpiperidin-1-yl)cyclopentanecarboxamides As High-Affinity and Long-Residence-Time Antagonists for the CCR2 Receptor
Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy.
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Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines
Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)
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Public leadership as a balancing act? How leaders’ context influences leadership
Public leadership received increasing attention, but we still do not understand how the context of public leaders affects leadership. This research project delves into public leaders’ perceptions of the leadership situations they find themselves in, which are characterised by multiplicity – one could…
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Governance of Innovation Project Management: Necessary and Neglected
Promotores: B.R. Katzy, J. de Vries, Co-Promotor: L.P. Groenewegen
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A bibliometric review of COVID-19 research in the crisis and disaster literature
In the wake of the COVID-19 pandemic, the pressing question is how this global health emergency impacted the research agendas of the field of crisis and disaster science. This article reviewed contributions in ten important crisis and disaster journals in the two and a half years following the COVID-19…
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Capitalism, Migration, War and Nationalism in an Aegean Port Town: The Rise and Fall of a Belle Époque in the Ottoman county of Foçateyn
This dissertation describes the history of the Ottoman county of Foçateyn as a case study of the process of transition from the Ottoman Empire to nation states.
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A History of Plague in Java, 1911–1942
In A History of Plague in Java, 1911–1942, Maurits Bastiaan Meerwijk demonstrates how the official response to the 1911 outbreak of plague in Malang led to one of the most invasive health interventions in Dutch colonial Indonesia.
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Optimization of Patient Flow through EMT Facilities Applying Dynamic Behavioral Simulation Models
This study aims to explore the use of a behavioral-design-based approach in simulating patient flow through EMTs. It provides a dynamic behavioral simulation model to assess the interactions between patients, staff members, and the related dynamic movements/interactions with the health care facility,…
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Conflict resolution by internet platforms
The Covid-19 'infodemic' and conflict resolution by internet platforms.
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Novel formulations and delivery strategies for inactivated polio vaccines: new routes with benefits
This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.
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About us
The Faculty of Archaeology at Leiden is the leading academic institute for Archaeology in the Netherlands, and one of the largest in the world. The Faculty is an international front-runner, in the top ten of the QS World University Ranking, at subject level.
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Targeted Informed consent: empowering young participants in medical-scientific research
Promotor: J.M. van den Broek Co-promotor: M.C. de Vries
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When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as
Source: Eur J Med Chem (2015)
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Affinity
Designing and synthesizing high-affinity ligands for a given drug target have always been among the more important challenges in the drug discovery process.
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Prof. dr. J.D. Speckmann prize
Annually the Institute of Cultural Anthropology and Development Sociology awards the Speckmann prize for the best Fieldwork NL report, as well as the most accomplished master’s thesis.
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Lockdowns, lethality, and laissez-faire politics. Public discourses on political authorities in high-trust countries during the COVID-19 pandemic
This study looks at population response to government containment strategies during initial stages of the COVID-19 pandemic in four high-trust Northern European countries–Denmark, Germany, the Netherlands, and Sweden–with special emphasis on expressions of governmental trust.
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Stakeholder-led Adaptation Strategies to Climate Change: Global Transformations and Governance Challenges Seed Grant
Agriculture is among the most vulnerable sectors to climate change and poorer countries face the most severe difficulties. Coffee farmers in Central America, for instance, are facing multiple and mutually reinforcing crises, including price shocks, outbreaks of pests and diseases, migration, and farm…
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Beyond UN75: A Roadmap for Inclusive, Networked & Effective Global Governance
Drawing on insights from past and contemporary scholars and world leaders, the report explores the concepts of a new social contract, a new global deal, and networked and inclusive multilateralism introduced recently by Secretary-General António Guterres to help the United Nations better grapple with…
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Animation: Why Leiden is the birthplace of the Janssen vaccine
If you'll soon be getting a COVID-19 vaccine, you might just get the Johnson & Johnson (Janssen) one. This vaccine was developed for the most part in Leiden – and this is no coincidence. Watch the animation below about the development of one of the vaccines in the fight against COVID-19.
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Allosteric Modulation
Allosteric modulation has long been recognized as a general and widespread mechanism for the control of protein function. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. This concept…
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Global Public Health (BSc Major of Liberal Arts and Sciences: Global Challenges)
Although the world has made tremendous progress in health, education, sanitation and hygiene, global public health challenges still exist. Disparities in health exist between and within nations as evidenced by inequalities in disease burden, mortality, nutrition and environmental well-being. How does…
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Towards a comprehensive understanding of (facilitating) teacher professional development
What are ‘missing links’ in research on teacher professional development trajectories? We focus on the role and development of teacher facilitators in designing and implementing (collaborative) professional development trajectories.
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Book presentations
Now and then we organise book launches to present the latest publications, both academic and popular, in our broad field.
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Receptor Residence Time
Research question
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The Postal Imagination: Returning Mail in Contemporary Culture
How to understand the simultaneously dis- and reappearance of letters in contemporary culture, and how does this Neo-Epistolarity relate to media-technological change?
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Functions of autophagy in the filamentous fungus Aspergillus niger
What are the functions of autophagy in the filamentous fungus Aspergillus niger?
- Neerlandistiek Master Universiteit Leiden
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Past Events
The Risk and Regulation Lab from organises events and workshops in Leiden and The Hague. On this page you can read reports of the events that already took place.
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Israel-Palestine
This dossier is for all members of our academic community who want to contribute to an open dialogue and wish to find out more about the context of the Israel-Palestine conflict.
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Hall of Fame 2023
In 2023, many of our students and staff won great prizes and secured important research grants.
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‘First determine goals, then make healthcare choices’
What are the goals of healthcare? That very question must be asked more frequently before healthcare-related choices are made. This is what Martine de Vries, Professor of Normative Aspects of Medicine, advocated during her inaugural lecture on Friday, 2 November 2018.
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10 million for research into disease transmission by mosquitoes
How can the Netherlands be better prepared for infectious diseases transmitted by mosquitoes. The Dutch Research Council (NWO) has awarded almost 9 million euros for this research. Maarten Schrama from the Institute of Environmental Sciences CML coordinates the input of Leiden University within the…
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Our people
Some examples of AI-research done at Leiden.
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Kraft Lab - Self-assembly in Biological and Soft Matter
Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.
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Key publications
Key publications of the Predictive Pharmacology group.
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Cell Wall Dynamics in Aspergillus niger
This functional genomics project aims at understanding the biology of the underlying mycelium differentiation and autolysis processes in much more detail.
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Research and design in secondary science education
Research and design are becoming more and more important in international science education. In The Netherlands, two recently introduced subjects focus on research and design activities in the classroom: O&O (research and design) and NLT (nature, life and technology). This research aims to look at what…
- Career prospects
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Allosterism
The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…