352 search results for “sousa exposure” in the Public website
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Quantifying the toxicity of mixtures of metals and metal-based nanoparticles to higher plants
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Predicted microplastic uptake through trophic transfer by the short-beaked common dolphin and common bottlenose dolphin
In this study, Tessa Dool and Thijs Bosker estimate the microplastic uptake of two odontocetes in the Mediterranean Sea and the Norteast Atlantic.
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Structural characterization of the cell envelope of Actinobacteria under changing environments
Bacteria have the ability to alter their morphology in order to adapt to changing environments.
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Integrating cellular and tissue dynamics with cell fate decisions through computational modeling
There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…
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Research
Although there has been an increase in the research into brain function and dysfunction in relation to stress and emotions, there are still many unanswered questions.
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36 ditches as living lab for water quality
On Monday 14 November, the first spadeful of earth was dug for the construction of the Living Lab, an experimental test site to study living organisms in freshwater. A total of 36 ditches will be dug out to create a natural environment where researchers can study the effects of chemical compounds from…
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Courses offered
In the academic year 2023-2024 the SRS interdisciplinary programme will offer four courses for interested students who are entering the third year of their Bachelor's degree. You can sign up for these courses in your elective (minor) space. You can follow the courses individually as an elective, or…
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GLOBOX
GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.
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Rianne de Kleine using Veni grant to study post-traumatic stress
Can we improve the treatment of post-traumatic stress disorder (PTSD)? Our young and promising psychologist Rianne de Kleine receives a Veni grant to carry out her research on the treatment of post-traumatic stress.
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Monitoring and detection of nanomaterials in biological media.
How do nanoparticles bioaccumulate and biodistribute in organisms?
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Ethnic disadvantage and adolescents’ emotional- and behavioural problems
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Development of a consistent methodology for assessment of the combined effects of metal-based chemicals to lettuce (Lactuca sativa L.)
How to improve the method in quantifying the combined effects of metal-based chemicals?
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‘There’s still much to discover in developmental biology’
It is the dream of Professor Susana Chuva de Sousa Lopes to grow fertile egg cells in the lab. But she says there is a long way to go in her discipline until that is possible. This is the message of her inaugural lecture on 29 June 2020, the first digital inaugural lecture at Leiden University.
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Effects of pesticides on aquatic macrofauna in the field
Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver
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Mathematical modeling of cellular stress pathways for mechanistic understanding of chemical-induced liver injury
Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…
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Functionalizing monolayer graphene as a proton-selective membrane for direct methanol fuel cells
This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.
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Toxicity, bioaccumulation and trophic transfer of engineered nanoparticles in the aquatic environment
The findings in this thesis improve the understanding of 1) the relationship between exposure characteristics and toxicity of ENPs, 2) the joint toxic action of ENP mixtures and the comparison to metal salt mixtures, 3) how NOM affects the individual and joint toxicity of ENPs, 4) the extent of trophic…
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[sbb] Launching Next-Generation Products in a Competitive Market
When to launch a next-generation product in a competitive market and how much capacity should be allocated to it
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Dynamics and regulation of the oxidative stress response upon chemical exposure
PhD defence
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Bestrijdingsmiddelenatlas (BMA) - Pesticide Atlas of Dutch surface waters
Improving environmental risk assessment of pesticides in surface waters
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Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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Retributive or reparative justice? Explaining post-conflict preferences in Kenya
This study adds nuance to the empirical literature that interrogates the link between exposure to mass violence and post-conflict justice preferences.
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Gewijd der Jeugd voor taal en deugd: Het onderwijs in de Nederlandse taal op de lagere school, 1750-1850
On December 6th, Bob Schoemaker succesfully defended his doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Bob on this great result.
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About us
All living creatures have to cope with environmental demands and threats that challenge their physical or emotional homeostasis.
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Off the wall: characterisation and exploitation of a cell wall deficient life style in filamentous actinomycetes
Almost all bacteria are enveloped by a cell wall that provides cellular protection.
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Children’s time spending and social interaction networks
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
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Counteracting subliminal cues that threaten national identity
A new paper written by Jolien van Breen, Soledad de Lemus, Russell Spears & Toon Kuppens in the British Journal of Social Pscychology examines the impact of the 2008-2012 financial crisis on national identity in Spain.
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Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
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Individualized dosing of aminoglycosides and glycopeptide antibiotics in (morbidly) obese patients (AMIGO)
Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).
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Developmental effects of polystyrene nanoparticles in the chicken embryo
There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.
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When materials become critical: lessons from the 2010 rare earth crisis
Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn
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The noise of the hunt: effects of noise on predator-prey relationships in a marine ecosystem
The effects of anthropogenic noise on interactions between predators and their prey are still little understood.
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The added value of multimedia to repeated story book reading in preschool age
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Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
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Tools and Data
Software and Data of the department Industrial Ecology
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Comparative biology of common and grey seals along the Dutch coast : stranding, disease, rehabilitation and conservation
Promotores: H.A. Udo De Haes, P.M. Brakefield
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Quantitative pharmacology of antimicrobials
Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.
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Mitochondria in chemical-induced toxicity
Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…
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Metabolomics assisted with stable-isotope labeling: exploring neuronal metabolism related to Parkinson’s disease
The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.
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Synthesis of chemical tools to study the immune system
This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.
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Understanding the uptake and internal distribution of metallic nanoparticles in Danio rerio larvae
The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.
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Unpacking the effects of burdensome state actions on citizens' policy perceptions
In this article, Martin Sievert and Jonas Bruder investigated whether and how administrative burdens influences citizens' perceptions of welfare policies and attitudes towards beneficiaries.
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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Nanomaterial safety for microbially-colonized hosts: Microbiota-mediated physisorption interactions and particle-specific toxicity
The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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Probing molecular layers with low-energy electrons
Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…
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Open Call How do you experience a quieter city?
How do you experience a quieter city? Or a silenced city? Our cities are normally filled with noise. The corona crisis has changed that. Few or no people on the streets, shops closed, much less traffic, hardly any planes coming over. The soundscape of the city has completely changed. Soundtrackcity,…