The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.

Interaction between Legal Systems acknowledges that law-making and law enforcement are increasingly taking place on various levels: in a global context, in EU context, on a national level and in a private law framework. These levels influence each other, sometimes directly, on the basis of a hierarchical…

How do balanced lethal systems originate and persist in nature?

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.

Grammatical gender is famously the most puzzling of the grammatical categories. We have a solid typology of gender systems, yet exciting and unexpected patterns keep turning up which defy easy classification and straightforward analysis. Some of these question, stretch or threaten to cross the outer…

This book explores the boundaries of the category of gender and their theoretical significance within the framework of Canonical Typology.

We study the physics of a broad range of biological and soft materials

The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

At Leiden University we believe it is important that you receive the right kind of support in your choice of study and while you study. This is why we use what we call the ‘Leiden study system’ to help you make a success of your study from start to finish.

The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…

Duality, stochastic processes

This interdisciplinary research project explores several adaptive machine learning methods which can give insight into the interaction between human and machine. The ultimate goal is open and natural communication between humans and AI that should result in mutual trust, cooperation and coordination…

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

In this article, Marco Cinelli, assistant professor at Leiden University College The Hague, examines proper and improper uses of Multiple Criteria Decision Analysis (MCDA) methods in energy systems analysis.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

How can Ronald Mulder run his skates across an ice layer at 60 km/h? His skating blades get help from a lubricating layer of meltwater. In Leiden, physicists found this explanation to be incomplete. Theoretician Hans van Leeuwen and experimental physicist Tjerk Oosterkamp searched for a deeper answe…

Research into research improves the academic system. CWTS studies and evaluates the academic system in various ways. One way is to provide information on the productivity and impact of academics by documenting how many publications they or their universities produce and how often these publications…

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Increasing above- and belowground biodiversity in arable leek cultivation to stimulate pest control by natural enemies.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

An important hormone excreting gland in the human body is the pituitary

Promotor: Prof.dr. S.F. Portegies Zwart, Co-promotor: D.C. Heggie

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Dishoeck

How are carbohydrates processed by the immune system? Can carbohydrates be used to trigger T-cells against other conjugated antigens? Can they be used as adjuvants?

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

On the 23rd of March, Alessandro del Tomba successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Alessandro on this achievement!

Promotor: S.M. Verduyn Lunel