518 search results for “lipid chris leon” in the Public website
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Leone Pecorini Goodall
Faculty of Humanities
l.f.pecorini.goodall@hum.leidenuniv.nl | +31 71 527 1125
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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The role of lipids in the barrier function of the skin
The outermost layer of the skin, the stratum corneum (SC), is responsible for the skin barrier function, protecting the body from pathogens, chemicals and other unwanted substances from the external environment. The SC lipid matrix provides the only continuous pathway through the SC and is considered…
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Pablo Mendes De Leon
Faculteit Rechtsgeleerdheid
p.m.j.mendes.de.leon@law.leidenuniv.nl | +31 71 527 2727
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Arturo García De León
Faculteit Archeologie
a.j.garcia.de.leon@arch.leidenuniv.nl | +31 71 527 2727
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Intercellular Skin Barrier Lipid Composition and Organization in Netherton Syndrome Patients
Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…
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Understanding the physical properties that affect the lipid organization in the skin barrier
It is the aim of this project to better understand how the physical properties of lipids influences the structure and overall barrier function of the skin.
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systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
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Tim Joseph Chris de Coster
Science
t.j.c.de.coster@math.leidenuniv.nl | +31 71 527 2727
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Phase separation in lipid-based nanoparticles: exploring the nano-bio interface
This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.
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Skin Lipids: Localization of Ceramide and Fatty Acid in the Unit Cell of the Long Periodicity Phase
The lipid matrix of the skin's stratum corneum plays a key role in the barrier function, which protects the body from desiccation. The lipids that make up this matrix consist of ceramides, cholesterol, and free fatty acids, and can form two coexisting crystalline lamellar phases: the long periodicity…
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Gaining control of lipid-based nanomedicine by understanding the nano-bio interface
Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…
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Lipid signaling and inflammation: metabolomics for better diagnosis and treatment strategy
Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…
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Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition
Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.
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Combined LC/MS-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes
Ceramides (CERs), cholesterol, and free fatty acids (FFAs) are the main lipid classes in human stratum corneum (SC, outermost skin layer), but no studies report on the detailed analysis of these classes in a single platform.
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Monounsaturated fatty acids reduce the barrier of stratum corneum lipid membranes by enhancing the formation of a hexagonal lateral packing
The effectiveness of the skin barrier underlies the outer layer of the skin: the stratum corneum (SC). However, in several skin diseases this barrier is impaired. In two inflammatory skin diseases, atopic eczema and Netherton syndrome, an increased level of monounsaturated fatty acids (MUFAs) has been…
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Lipid to protein ratio plays an important role in the skin barrier function of atopic eczema patients
OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.
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Reduced stratum corneum lipid chain length relates to an impaired skin barrier function in patients with atopic dermatitis
Source: British Journal of Dermatology, Volume 170, Number 6, pp. E18-E19 (2014) ISBN:0007-0963
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PhD thesis award for Biologist Chris Jacobs
Chris Jacobs, former PhD-student of the IBL, received the national “Dissertation Award” for best PhD thesis of the year on insects. The award was handed out last Friday, the 18th of December, by Professor Matty Berg, president of the Dutch Entomological Society.
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Children in Sierra Leone thrilled with pens from KOG cleaner Lamin
For almost ten years now Lamin Sow, a cleaner working at the Kamerlingh Onnes Building, has been collecting discarded pens he comes across throughout the day. When he returns to his home country he takes the pens with him as gifts for children.
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Chris Smiet wins Christiaan Huygens prize
Christopher Berg Smiet, who defended his thesis at LION with Dirk Bouwmeester, won the Christiaan Huygens prize for his thesis '‘Knots in Plasma’. On 7 October, he received a certificate, a bronze statuette and ten thousand euros.
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A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Exploring the potentials of nurture: 2(nd) and 3(rd) generation explant human skin equivalents
BACKGROUND: Explant human skin equivalents (Ex-HSEs) can be generated by placing a 4mm skin biopsy onto a dermal equivalent. The keratinocytes migrate from the biopsy onto the dermal equivalent, differentiate and form the epidermis of 1(st) generation Ex-HSEs. This is especially suitable for the expansion…
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HERA grant awarded to Léon Buskens and international colleagues
Together with internationally esteemed colleagues, Léon Buskens has been awarded a HERA Joint Research Programme Grant for a research project entitled
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An ex vivo human skin model for studying skin barrier repair
In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.
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Chris Riddell is new Face of Science: 'Can't wait to share research'
Have you ever seen your friend smiling, and suddenly you started grinning too? PhD student Chris Riddell is researching how and why we copy body language. As a new Face of Science, he will take us along on his research journey for the coming year.
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LUMC researchers: high levels of lipids in blood protect against allergies
People with relatively high levels of lipids in their blood are less likely to develop allergic conditions such as eczema and asthma. These lipids cause genes that play a key role in allergic reactions to be less active. Researchers from the Leiden University Medical Center (LUMC) have published an…
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GTGC lunch seminar: Chris Wensink & Midas van Dijk on Regionalizing Eurasia
As part of the GTGC Lunch Seminars, Chris Wensink and Midas van Dijk presented their book 'Regionalizing Eurasia'. The COVID-19 pandemic restricted travel and placed free trade under scrutiny. Then, the war in Ukraine triggered unprecedented economic sanctions and severing of trade ties. By contrast,…
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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Studio Leon Thier has been nominated for the architectural award ‘New Berlage Flag’
Studio Leon Thier Architectuur/Interieur is the architectural firm behind the interior design of Wijnhaven, and with this project they have been nominated for the architectural award the ‘New Berlage flag’. The award has been introduced by the Hague Architecture Café (HaAC) and the BNA. The award goes…
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MSc Research Presentation Chris Kettenis 21 December @ 15:30, EM1.19 Gorlaues Building
The project has been done in the Biological Matter group under the supervision of Prof. dr. ir. S.J.T. van Noort and Prof. dr. M.A.G.J. Orrit.The title of the presentation is: ''Characterization of Single Gold Nanorods with Two Photon Microscopy.
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Minister overhandigt eerste exemplaar boek Pablo Mendes de Leon en Niall Buissing
The Dutch Minister for Infrastructure and Watermanagement Cora van Nieuwenhuizen has offered the first copy of the book ‘Behind and Beyond the Chicago Convention: The Evolution of Aerial Sovereignty’ to the Secretary-General of the International Civil Aviation Organization (ICAO).
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Polymers in the Liver: Metabolism and Regulation
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…
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Evolutionary molecular dynamics
This thesis introduces the concept of
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In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
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ILS Lunch Seminar before the summer break with Prof. Pablo Mendes de Leon and Albert van Marwijk Kooy
On Thursday 27 June, the last festive ILS Lunch Seminar of this academic year takes place. This seminar will feature presentations from two distinguished speakers from different departments of Leiden Law School: Prof. Pablo Mendes de Leon and Albert van Marwijk Kooy.
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Alumnus Chris Colijn on his traineeship at a think tank, his master’s degree and advice for other graduates
What does life look like after International Studies? For Chris Colijn who graduated in 2018, it involves working on his master’s in Russian and Eurasian Studies, in combination with a bustling traineeship for “Raam of Rusland”, a think tank, focusing on Russian and Ukrainian politics, economy and culture.…
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Impaired barrier of inflammatory skin diseases
Focus in skin research
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Research lines
Current research at the Skin Barrier and Vaccination group.
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Travelling through the body with graphene
For the first time researchers have succeeded in placing a layer of graphene on top of a stable fatty lipid monolayer. Surrounded by a protective shell of lipids, graphene could enter the body and function as a versatile sensor. The results are the first step towards such a shell, and have been published…
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The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients
An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function.
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Michel Doortmont
Afrika-Studiecentrum
m.r.doortmont@asc.leidenuniv.nl | +31 71 527 2727
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A novel biofilm for skin barrier repair of patients with atopic eczema
Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Skin Barrier and Vaccination
The Skin Barrier and Vaccination group is led by Prof. Joke Bouwstra. One of the key functions of the skin is its barrier function, which is located in the uppermost layer of the skin, the stratum corneum. The stratum corneum consists of enucleated dead cells (corneocytes) embedded in a lipid matrix.…
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The effect of the chain length distribution of free fatty acids on the mixing properties of stratum corneum model membranes
The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.