457 search results for “lipid chair leon” in the Public website
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Combined LC/MS-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes
Ceramides (CERs), cholesterol, and free fatty acids (FFAs) are the main lipid classes in human stratum corneum (SC, outermost skin layer), but no studies report on the detailed analysis of these classes in a single platform.
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Monounsaturated fatty acids reduce the barrier of stratum corneum lipid membranes by enhancing the formation of a hexagonal lateral packing
The effectiveness of the skin barrier underlies the outer layer of the skin: the stratum corneum (SC). However, in several skin diseases this barrier is impaired. In two inflammatory skin diseases, atopic eczema and Netherton syndrome, an increased level of monounsaturated fatty acids (MUFAs) has been…
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Lipid to protein ratio plays an important role in the skin barrier function of atopic eczema patients
OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.
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Regulation of the immune response by unsaturated lipid mediators in the context of the osteoarthritic joint
PhD defence
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Learning Chairs
In the Department of Business Sciences, three chairs are established. Together, the chair holders lead the Turnaround, Rescue & Insolvency Leiden Research Team (TRI Leiden), which consists of legal and business science researchers from Leiden Law School. TRI Leiden aims, through an international and…
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Reduced stratum corneum lipid chain length relates to an impaired skin barrier function in patients with atopic dermatitis
Source: British Journal of Dermatology, Volume 170, Number 6, pp. E18-E19 (2014) ISBN:0007-0963
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Cleveringa chair
The Cleveringa chair was installed by Leiden University in memory of Professor Rudolph Pabus Cleveringa and the courage he demonstrated in November 1940 during the German occupation (1940-1945). It also commemorates the liberation of the Netherlands in 1945.
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Pascal chair at LIACS
The Leiden Institute of Advanced Computer Science (LIACS) of Leiden University proudly establishes the Blaise Pascal chair. The chair applies for one year and is meant to strengthen the cooperation of the Leiden computer science research with foreign institutes.
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EU Chair Holder
Irma Johanna Mosquera Valderrama is Full Professor Global Tax Governance, EU Holder Jean Monnet Chair EUTAXGOV at Leiden Law School (Leiden University), the Netherlands and Lead Researcher of the European Research Council (ERC) Funded Project – GLOBTAXGOV.
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Pascal chair 2023
Peter Flach is Professor of Artificial Intelligence at the University of Bristol. An internationally leading scholar in the evaluation and improvement of machine learning models using ROC analysis and calibration, he has also published on mining highly structured data, on knowledge-driven and explainable…
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Van der Heijden Chair Social Justice
On the occasion of prof Paul van der Heijden’s stepping down as Rector Magnificus and President of the Executive Board of Leiden University in 2013 the Chair bearing his name on Social Justice was established. It was a “farewell present” of the Leiden University to it’s Rector.
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Jean Monnet Chair of Moritz Jesse
Moritz Jesse has been awarded a Jean Monnet Chair by the European Commission. In his MIND-EU Project he will focus on a coherent way to teach Migration, Integration, and Non-Discrimination at Leiden Law School at bachelor and master level.
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Children in Sierra Leone thrilled with pens from KOG cleaner Lamin
For almost ten years now Lamin Sow, a cleaner working at the Kamerlingh Onnes Building, has been collecting discarded pens he comes across throughout the day. When he returns to his home country he takes the pens with him as gifts for children.
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UNESCO Chair on Diversity and Inclusion in Global Science
This UNESCO Chair at CWTS aims to contribute to UNESCO’s agenda to foster diversity and inclusion in science. The chair has two main lines of work:
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Chair of UN Studies in Peace and Justice
From 1 August 2018, Alanna O'Malley was appointed as Chair of United Nations Studies in Peace and Justice, focusing on the ‘lesser-known actors’ of the UN: women, the youth, the agents of informal diplomatic networks within the UN and actors from the Global South. This Special Chair has been created…
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A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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HERA grant awarded to Léon Buskens and international colleagues
Together with internationally esteemed colleagues, Léon Buskens has been awarded a HERA Joint Research Programme Grant for a research project entitled
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Exploring the potentials of nurture: 2(nd) and 3(rd) generation explant human skin equivalents
BACKGROUND: Explant human skin equivalents (Ex-HSEs) can be generated by placing a 4mm skin biopsy onto a dermal equivalent. The keratinocytes migrate from the biopsy onto the dermal equivalent, differentiate and form the epidermis of 1(st) generation Ex-HSEs. This is especially suitable for the expansion…
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An ex vivo human skin model for studying skin barrier repair
In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.
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LUMC researchers: high levels of lipids in blood protect against allergies
People with relatively high levels of lipids in their blood are less likely to develop allergic conditions such as eczema and asthma. These lipids cause genes that play a key role in allergic reactions to be less active. Researchers from the Leiden University Medical Center (LUMC) have published an…
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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Studio Leon Thier has been nominated for the architectural award ‘New Berlage Flag’
Studio Leon Thier Architectuur/Interieur is the architectural firm behind the interior design of Wijnhaven, and with this project they have been nominated for the architectural award the ‘New Berlage flag’. The award has been introduced by the Hague Architecture Café (HaAC) and the BNA. The award goes…
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Minister overhandigt eerste exemplaar boek Pablo Mendes de Leon en Niall Buissing
The Dutch Minister for Infrastructure and Watermanagement Cora van Nieuwenhuizen has offered the first copy of the book ‘Behind and Beyond the Chicago Convention: The Evolution of Aerial Sovereignty’ to the Secretary-General of the International Civil Aviation Organization (ICAO).
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Polymers in the Liver: Metabolism and Regulation
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…
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Evolutionary molecular dynamics
This thesis introduces the concept of
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ILS Lunch Seminar before the summer break with Prof. Pablo Mendes de Leon and Albert van Marwijk Kooy
On Thursday 27 June, the last festive ILS Lunch Seminar of this academic year takes place. This seminar will feature presentations from two distinguished speakers from different departments of Leiden Law School: Prof. Pablo Mendes de Leon and Albert van Marwijk Kooy.
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In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
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Launch Owada Chair
On 24 May 2022, the universities of Tokyo and Leiden organized a rotating chair named after Professor Hisashi Owada. The Owada Chair focused on the interaction between international law and international relations in an interdisciplinary perspective. Dominique Moïsi, a professor at Kings College London…
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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New Kikkoman chair in Leiden
The Kikkoman chair is a new chair in Leiden sponsored by the Kikkoman Foundation and the Association of Friends of Asiatic Art. The chair will address the intercultural dynamics of Asia and Europe.
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Freya Baetens awarded Francqui Chair
Freya Baetens, Professor of European Law, has been awarded a Chair by the Francqui Foundation in Belgium for the impact of her work on lawmaking and policymaking in Europe and beyond.
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Impaired barrier of inflammatory skin diseases
Focus in skin research
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Research lines
Current research at the Skin Barrier and Vaccination group.
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Travelling through the body with graphene
For the first time researchers have succeeded in placing a layer of graphene on top of a stable fatty lipid monolayer. Surrounded by a protective shell of lipids, graphene could enter the body and function as a versatile sensor. The results are the first step towards such a shell, and have been published…
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New Owada chair in Leiden and Tokyo
The universities of Tokyo and Leiden are installing a rotating chair named after Professor Hisashi Owada. The Owada chair will focus on interaction between international law and international relations through interdisciplinary approaches. Dominique Moïsi, a professor at King’s College in London, will…
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Michel Doortmont
Afrika-Studiecentrum
m.r.doortmont@asc.leidenuniv.nl | +31 71 527 2727
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Word from the LUCSoR Chair
Welcome to 2024! I hope this message finds you doing well and reenergised following the holiday season. With that said, I can imagine that many of us are not quite ready to be back in the classroom (either as a student or a lecturer)! The good news is that we have plenty of activities to jump start…
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The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients
An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function.
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Karolina Pomorska awarded Jean Monnet Chair
Political scientist Karolina Pomorska (Institute of Political Science, Leiden University) has been awarded a Jean Monnet Chair. The aim of her chair, entitled The EU and the World, is to promote and strengthen teaching and research in European Studies in Leiden and in The Hague.
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A novel biofilm for skin barrier repair of patients with atopic eczema
Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Esther Philips elected as Chair of EARMA
Esther Philips, grant advisor at the Institute of Environmental Sciences, is the new Chair elect of the European Association for Research Managers and Administrators (EARMA).
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Skin Barrier and Vaccination
The Skin Barrier and Vaccination group is led by Prof. Joke Bouwstra. One of the key functions of the skin is its barrier function, which is located in the uppermost layer of the skin, the stratum corneum. The stratum corneum consists of enucleated dead cells (corneocytes) embedded in a lipid matrix.…
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The effect of the chain length distribution of free fatty acids on the mixing properties of stratum corneum model membranes
The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.
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Special Chair Organised and Subversive Crime Studies
Starting 1 July 2020, Pieter Tops will hold the special chair Organised and Subversive Crime Studies. The chair will be hosted by the Institute Security and Global Affairs (ISGA) at Leiden University's Faculty Governance and Global Affairs. Pieter Tops is a lector at the Police Academy. He conducts…
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.
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Student projects
Are you looking for a research project? We have projects available for motivated 6–9-month internship students with particular interest in organic/polymer synthesis, formulation development, gene delivery, protein delivery, and the preliminairy in vitro screening of drug delivery platforms. Students…