1,939 search results for “lipid chair lent” in the Public website
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Chair of UN Studies in Peace and Justice
From 1 August 2018, Alanna O'Malley was appointed as Chair of United Nations Studies in Peace and Justice, focusing on the ‘lesser-known actors’ of the UN: women, the youth, the agents of informal diplomatic networks within the UN and actors from the Global South. This Special Chair has been created…
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A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Exploring the potentials of nurture: 2(nd) and 3(rd) generation explant human skin equivalents
BACKGROUND: Explant human skin equivalents (Ex-HSEs) can be generated by placing a 4mm skin biopsy onto a dermal equivalent. The keratinocytes migrate from the biopsy onto the dermal equivalent, differentiate and form the epidermis of 1(st) generation Ex-HSEs. This is especially suitable for the expansion…
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An ex vivo human skin model for studying skin barrier repair
In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.
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LUMC researchers: high levels of lipids in blood protect against allergies
People with relatively high levels of lipids in their blood are less likely to develop allergic conditions such as eczema and asthma. These lipids cause genes that play a key role in allergic reactions to be less active. Researchers from the Leiden University Medical Center (LUMC) have published an…
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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Team 6 Quality assurance in education
In order to successfully implement the kernvisie, it is important to examine how we can improve the quality of our education.
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Team 3 Study supervision & matching
In order to better engage students in our education and offer demanding help to students to complete their studies, this team will work out which facilities should be set up for this purpose and what preconditions are needed.
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Polymers in the Liver: Metabolism and Regulation
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…
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Evolutionary molecular dynamics
This thesis introduces the concept of
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In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
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Launch Owada Chair
On 24 May 2022, the universities of Tokyo and Leiden organized a rotating chair named after Professor Hisashi Owada. The Owada Chair focused on the interaction between international law and international relations in an interdisciplinary perspective. Dominique Moïsi, a professor at Kings College London…
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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New Kikkoman chair in Leiden
The Kikkoman chair is a new chair in Leiden sponsored by the Kikkoman Foundation and the Association of Friends of Asiatic Art. The chair will address the intercultural dynamics of Asia and Europe.
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Freya Baetens awarded Francqui Chair
Freya Baetens, Professor of European Law, has been awarded a Chair by the Francqui Foundation in Belgium for the impact of her work on lawmaking and policymaking in Europe and beyond.
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Impaired barrier of inflammatory skin diseases
Focus in skin research
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Research lines
Current research at the Skin Barrier and Vaccination group.
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Travelling through the body with graphene
For the first time researchers have succeeded in placing a layer of graphene on top of a stable fatty lipid monolayer. Surrounded by a protective shell of lipids, graphene could enter the body and function as a versatile sensor. The results are the first step towards such a shell, and have been published…
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New Owada chair in Leiden and Tokyo
The universities of Tokyo and Leiden are installing a rotating chair named after Professor Hisashi Owada. The Owada chair will focus on interaction between international law and international relations through interdisciplinary approaches. Dominique Moïsi, a professor at King’s College in London, will…
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Word from the LUCSoR Chair
Welcome to 2024! I hope this message finds you doing well and reenergised following the holiday season. With that said, I can imagine that many of us are not quite ready to be back in the classroom (either as a student or a lecturer)! The good news is that we have plenty of activities to jump start…
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The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients
An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function.
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Karolina Pomorska awarded Jean Monnet Chair
Political scientist Karolina Pomorska (Institute of Political Science, Leiden University) has been awarded a Jean Monnet Chair. The aim of her chair, entitled The EU and the World, is to promote and strengthen teaching and research in European Studies in Leiden and in The Hague.
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A novel biofilm for skin barrier repair of patients with atopic eczema
Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Esther Philips elected as Chair of EARMA
Esther Philips, grant advisor at the Institute of Environmental Sciences, is the new Chair elect of the European Association for Research Managers and Administrators (EARMA).
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Skin Barrier and Vaccination
The Skin Barrier and Vaccination group is led by Prof. Joke Bouwstra. One of the key functions of the skin is its barrier function, which is located in the uppermost layer of the skin, the stratum corneum. The stratum corneum consists of enucleated dead cells (corneocytes) embedded in a lipid matrix.…
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The effect of the chain length distribution of free fatty acids on the mixing properties of stratum corneum model membranes
The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.
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Special Chair Organised and Subversive Crime Studies
Starting 1 July 2020, Pieter Tops will hold the special chair Organised and Subversive Crime Studies. The chair will be hosted by the Institute Security and Global Affairs (ISGA) at Leiden University's Faculty Governance and Global Affairs. Pieter Tops is a lector at the Police Academy. He conducts…
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Revolutie of zinsbegoocheling?
Wordt het nog wat met de Arabische lente?
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Professor and Knight: Joke Bouwstra Receives Royal Honor
A memorable farewell symposium and a royal distinction: Professor Joke Bouwstra could not have completed her career at Leiden with more pleasure. On Friday, 14 June, she received a Royal Honor from Leiden Mayor Peter van der Velden, who appointed Bouwstra as a Knight in the Order of the Dutch Lion for…
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Student projects
Are you looking for a research project? We have projects available for motivated 6–9-month internship students with particular interest in organic/polymer synthesis, formulation development, gene delivery, protein delivery, and the preliminairy in vitro screening of drug delivery platforms. Students…
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.
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Key publications
Key publications of the Skin Barrier and Vaccination group.
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Systems dermatology of immune-mediated dermatological diseases: cutaneous T-cell lymphoma
The complex pathophysiology of immuno-dermatological disorders is multifactorial, including environmental, skin microbiome, (epi)genetic and immune dysregulation conditions. This project primarily focuses on the orphan disease mycosis fungoides, a subtype of cutaneous T-cell lymphoma. The current pathophysiological…
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Interactions from Lipid Membrane Deformations
PhD defence
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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Anjali Pandit
Science
a.pandit@chem.leidenuniv.nl | +31 71 527 4198
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Sander Wezenberg
Science
s.j.wezenberg@lic.leidenuniv.nl | +31 71 527 4541
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Bart Barendregt on Unesco Chair in Anthropology of Digital Diversity
Bart Barendregt explains his new Unesco Chair in Anthropology of Digital Diversity in an interview on the Unesco website.
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Leiden University considers establishing chair for Workplace Pride
The Faculty of Social and Behavioural Sciences at Leiden University is considering establishing a special chair for Workplace Pride. The professor appointed to this chair will study opportunities for improving the position of lesbian women, homosexual men, bisexuals and transgender people (LGBTs) in…
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New special chair in Educational Theory and Law
Following a special donation, the Stichting Pro Juventute foundation is facilitating a new special chair in Educational Theory and Law. Through the chair, Pro Juventute hopes to realise optimum child protection from a coherent legal and educational perspective.
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Helen Pluut new chair of Young Academy Leiden
Young Academy Leiden brings together young researchers, gives them a say in policymaking and fosters interdisciplinary collaboration. Chair Tom Louwerse is passing on the baton to Helen Pluut. ‘Sharing your knowledge and experience with colleagues from other faculties and institutes is so valuable.’…
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Zipping into Fusion
Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros
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Physics implications of shape on biological function
Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.
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Development of formulation for treatment of Atopic Eczema
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Giant unilamellar vesicles: An efficient membrane biophysical tool and its application in drug delivery studies
Promotor: A. Kros
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Owada Chair should bring together nations, cultures and individuals
Dominique Moïsi, a professor at King’s College London, will be the first holder of the Owada chair. ‘In the present international context of polarisation and divisions within societies and amongst nations, any effort at bringing Asia and Europe closer to each other is truly important.’
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Marnix Medema new visiting professor Van der Klaauw chair
The Institute of Biology Leiden has a new visiting professor as of the first of May. Bioinformatician Marnix Medema holds the Van der Klaauw chair for a year and looks forward to scientific collaborations and to boost the bioinformatics education.