2,834 search results for “gene studies” in the Public website
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Crewe Williams
Faculty of Humanities
k.c.williams@hum.leidenuniv.nl | 071 5272171
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Xiao Luo
Faculty of Humanities
x.luo@hum.leidenuniv.nl | 071 5272171
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Francesca Rosati
Faculty of Humanities
f.rosati@hum.leidenuniv.nl | 071 5272171
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Steven Hagers
Faculty of Humanities
s.j.hagers@hum.leidenuniv.nl | 071 5272727
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Xiong Xiong
Faculty of Humanities
h.xiong@hum.leidenuniv.nl | 071 5272171
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Geoffrey Cain
Faculty of Humanities
g.n.cain@hum.leidenuniv.nl | 071 5272727
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Hyojin Pak
Faculty of Humanities
h.j.pak@hum.leidenuniv.nl | 071 5272727
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Newly discovered gene regulates balance of ‘bad cholesterol’
In a publication in Science, Noam Zelcer from the Division of Biopharmaceutics describes a previously unrecognized pathway to regulate LDL-cholesterol levels. He is also able to modulate this pathway. This opens the possibility for complementing and improving the efficacy of statins: A class of drugs…
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Ab de Jong
Faculty of Humanities
a.f.de.jong@hum.leidenuniv.nl | +31 71 527 2585
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Maghiel van Crevel
Faculty of Humanities
m.van.crevel@hum.leidenuniv.nl | +31 71 527 2211
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Henk Schulte Nordholt
Faculty of Humanities
schultenordholt@kitlv.nl | +31 71 527 2727
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Functions of leptin in tuberculosis and diabetes: multi-omics studies across species
In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.
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Maaike Smit-Beemsterboer
Faculty Governance and Global Affairs
m.beemsterboer@fgga.leidenuniv.nl | +31 70 800 9143
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Evolution and development of orchid flowers and fruits
To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.
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Key innate immune components controlling intracellular infection
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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Edegar Da Conceição Savio
Faculty of Humanities
e.da.conceicao.savio@hum.leidenuniv.nl | +31 71 527 2171
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Arfi Arfiansyah
Faculteit Rechtsgeleerdheid
a.arfiansyah@law.leidenuniv.nl | +31 71 527 2727
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Caroline Fernandes Caromano
Faculty of Humanities
c.fernandes.caromano@arch.leidenuniv.nl | +31 71 527 2727
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LUMC will administer first Dutch stem cell gene therapy to patients
Researchers and clinicians at Leiden University Medical Centre (LUMC) are about to begin a milestone clinical study. It will be the first time a stem cell gene therapy developed in the Netherlands is used in a clinic. The therapy will be used to treat children with SCID, a rare disorder where children…
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Cancer and heredity
Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.
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Caught in living cells: how bacteria regulate their genes to defend themselves
For the first time, it was shown in living cells how the bacterium E. coli regulates genes that help it survive in a new environment. Biochemist Fatema Zahra Rashid managed to do this using a technique she fine-tuned. Her research into changes in 3-dimensional chromosome structure offers clues for ways…
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May Shaddel Basir
Faculty of Humanities
m.shaddel.basir@hum.leidenuniv.nl | +31 71 527 2727
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First patient in the Netherlands successfully treated with stem cell gene therapy
Researchers from the Leiden University Medical Center (LUMC) have successfully used stem cell gene therapy to treat a baby with the severe congenital immune disorder SCID. An important milestone: it is the first time stem cell gene therapy of Dutch origin has been administered to a patient, and also…
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Shape Analysis for Phenotype Characterisation from High-throughput Imaging
We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Discovery and exploitation of the transcriptional regulatory system of pectinases in Aspergillus niger
Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.
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Judith Frishman
Faculty of Humanities
j.frishman@hum.leidenuniv.nl | +31 71 527 2727
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Marat Markert
Faculty of Humanities
m.markert@hum.leidenuniv.nl | +31 70 800 9934
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Eftychia Mylona
Faculty of Humanities
e.mylona@hum.leidenuniv.nl | +31 70 800 9962
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Shuqi Jia
Faculty of Humanities
s.jia@hum.leidenuniv.nl | +31 71 527 2171
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Kiyan Foroutan
Faculty of Humanities
k.foroutan@hum.leidenuniv.nl | +31 71 527 2727
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Maria Riep
Faculteit Archeologie
m.riep@arch.leidenuniv.nl | 071 5272171
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Shahab Daneshvar
Faculty of Humanities
s.daneshvar.2@hum.leidenuniv.nl | 071 5272171
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Profiling Endophenotypes in Social Anxiety Disorder – a family study
The key question addressed in this family study is whether the psychophysiological and neurocognitive abnormalities often reported in SAD patients are heritable and can thus be found in family members of SAD patients as well. Determination of heritability of these deficiencies is essential for endophenotyping.…
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Disentangling drought-responsive traits with focus on Arabidopsis
In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…
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Modulating the behaviour of pancreatic tumour cells
Promotores: Prof.dr. M.K. Richardson, Prof.dr. H.P. Spaink
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Role of epigenetics in long-term health effects of early life stress
Can epigenetic changes explain associations between early life stress and health outcomes?
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R-ELEVATION
How do plant defense genes get activated?
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Understanding disease suppressive soils
Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.
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Lipidomics study in liver metabolic diseases
The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.
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Mubarika Nugraheni
Faculty of Humanities
m.d.f.nugraheni@hum.leidenuniv.nl | +31 71 527 2171
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Pilar Jimenez Galindo
Faculty of Humanities
m.d.p.jimenez.galindo@hum.leidenuniv.nl | +31 71 527 1646
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Tim Wuisman
Faculty Governance and Global Affairs
t.wuisman@fgga.leidenuniv.nl | +31 70 800 9506
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Arie van der Kooij
Faculty of Humanities
a.van.der.kooij@hum.leidenuniv.nl | +31 71 527 2171
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Rients de Boer
Faculteit Archeologie
r.de.boer@arch.leidenuniv.nl | +31 71 527 2727
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Daný van Dam
Faculty of Humanities
h.d.j.van.dam@hum.leidenuniv.nl | +31 71 527 2727
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Berthe Jansen
Faculty of Humanities
b.k.jansen@hum.leidenuniv.nl | +31 71 527 2379
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Chunli Song
Faculty of Humanities
c.song@hum.leidenuniv.nl | 071 5272171
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Jan Kees Colder
Faculty of Humanities
j.c.colder@hum.leidenuniv.nl | 071 5272727