This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

Cell adhesion signaling

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

What is the optimal investment policy according to which a firm adapts its capacity in a competitive market?

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

Schemas are knowledge structures that allow us to make efficient judgments about the world without the cost of memorizing every detail of previous experiences. It has long been known that schemas can enhance long-term memory for related information.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

This minor focuses on how our thoughts, emotions and behaviour are influenced by other people, and how we influence other people.

Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…

Health inequities, obesity among children, loneliness, performance stress among youngsters. What are the drivers behind such ‘wicked problems’ and how might they be related? This interdisciplinary minor offers you the possibility to work with societal partners to gain a deeper understanding of real-life…

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

We study the physics of a broad range of biological and soft materials

Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

This functional genomics project aims at understanding the biology of the underlying mycelium differentiation and autolysis processes in much more detail.

This dissertation shows that dialogical logic constitutes a powerful and flexible general framework for the development and study of various logical formalisms and combinations thereof.

Promotor: Prof.dr. G.J. Kroes

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

On 29 October 2020, the Europa Institute Zurich organized a conference entitled «1. Zürcher Europarechtstag: Europäische Integration, Drittstaaten und (direkte) Demokratie» (1st Zurich European Law Day: European integration, third countries and (direct) democracy

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

This research focuses on the (Quantum) Dynamics (QD) of the reactive scattering of H2 from metal surfaces.

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

The work presented in this thesis addresses the role of the locus coeruleus (LC) - norepinephrine (NE) system in various aspects of human cognition, and the modulation of brain state.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

What are the principles of genome folding and dynamics in bacteria?

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Lecture, LUCL Colloquium - Series '24/'25

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

Isis on the Nile. Egyptian gods in Hellenistic and Roman Egypt

The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.

To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

How citizens and professionals are the key to successful collaboration in the delivery of public services. How do individual characteristics of citizens and professionals influence citizen-professional collaboration in the co-production of public services?

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…

Promotor: J.N. Kok, Co-promotor: H.J. Hoogeboom

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

What are the functions of the endocannabinoid system?

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth