In a longitudinal study, Eichengreen and colleagues explored how the certain aspects of emotional intelligence impact the development of adolescents’ mental health, thus identifying potential warning signs and targets for intervention programs. Despite a higher risk for mental health issues and lesser…

Cell adhesion signaling

Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…

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What happens to electrical waves that have to cross gaps in insulation material around nerves in the human body

Didactics

How can teachers be motivated by their students’ data in making stepwise changes to their teaching practices?

We consider the propagation of electrical signals through nerve fibres.

A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…

Promotores: P. Stevenhagen, L. van Geemen Co-promotor: R.M. van Luijk

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…

Anja Groten investigates matters of collectivity, drawing from the experience of working with the Amsterdam-based collective Hackers & Designers (H&D)*.

Collaborative linguistic research on indigenous languages of Ecuador: description, documentation & materials

25 years after the publication of Derrida’s Politics of Friendship (Politiques de l’amitié, 1994), this edited collection gathers 23 critical chapters that revisit this underappreciated text. Engaging closely with Derrida’s text, the contributors analyse, extend and critique the work. They reconsider…

Through a range of case studies spanning the post-Cold War period in Iraq, Moldova and Serbia, this book studies asymmetric conflicts where warring sides exhibit vast power differentials.

The subject areas covered encompass functional genomics, signal transduction, cellular differentiation, development, host-microbe interactions and animal behaviour.

Managing Diversity: Supervising Functions in Managing Colonial Workplaces

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center with Boston Children’s Hospital in the USA.

When to launch a next-generation product in a competitive market and how much capacity should be allocated to it

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

The central aim is to systematically study differences in gendered crime patterns in the records of different types of courts in various Dutch cities in the early modern period.

This Research project is funded by the 7th European Community Framework Programme, with additional funds from NWO Aspasia grant, and in collaboration with University of California, Berkeley.

1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI

This paper provides an initial answer to the question regarding eco-labels: ‘How can we make the development of eco-labels more structured and transparent?’

This study examined the effects of a classroom-focused intervention on different domains of early literacy. The intervention consisted of shared e-book reading combined with a print referencing technique done via a SMART board. The specific goal of the study was to examine whether children could be…

Paisaje, cerámicas e interacciones

Mr. Ade Jaya Suryani defended his thesis on 28 January 2021

Summary

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

This dissertation explores matters of collectivity, drawing from the experience of working with the Amsterdam-based collective Hackers & Designers (H&D).

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

This dissertation investigates ikat from the eastern Indonesian islands from a uniquely technical perspective, including design analysis of asymmetry and microscopy.

Abrupt Climate Change and Cultural Transformation

Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Promotor: Prof.dr. T. Schmidt

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

Promotor: Prof.dr. F. den Hollander

On the 29th of June, Martin Kohlberger successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Martin on this achievement!

Investigating specific language and speech behaviour of people.