Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Material Crossovers

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Experience, Narrative, and Criticism in Ancient Greece pursues a new approach to ancient Greek narrative beyond the taxonomies of structuralist narratologies.

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

The Egyptian hieroglyphic script was exceptionally versatile, as becomes clear when studying its multiple uses both within Ancient Egypt and beyond its borders.

For three millennia, carved sculptures were ubiquitous among ancient peoples in the Americas. Sculpted in stone, metal or wood, they developed into the well-known totem poles, colossal Olmec heads, royal Maya stelae and golden Inca statues.

Researchers at Leiden University have mapped genes that cause breast cancer cells to migrate. The Leiden toxicologists Professor Bob van de Water, Dr Wies van Roosmalen, Dr Sylvia E. Le Dévédec and colleagues studied 1500 individual genes. They found eight, including the SRPK1 gene, that regulate the…

With the aid of physics and a minuscule magnet, researchers have discovered a new structure of telomeric DNA. Telomeres are sometimes seen as the key to living longer. They protect genes from damage but get a bit shorter each time a cell divides. If they become too short, the cell dies. The new discovery…

Harvesting rice from the same field, without planting new rice plants? A discovery may bring this scenario closer. Leiden scientists have discovered a gene that allows annual plants to grow after flowering, instead of dying. Publication on 13 April in Nature Plants.

In this dissertation, the types of context Dutch speakers need to interpret the poly-interpretable word ergens ‘somewhere/anywhere’ are studied.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

We exploit secondary metabolites of plant to develop pharmaceutical compounds and we genetically modify plant genomes to improve crops.

This publication of the School of Advanced Study of the University of London is one of the outcomes of the Landscapes of Early Roman Colonization project and the Colonial Rural Networks project (NWO, Dr. T.D. Stek). The volume, edited by Tesse Stek and prof. Gert-Jan Burgers of the Free University Amsterdam,…

Just like us, plants also produce growth hormones, and they also go through an ageing process. The study of the genes and mechanisms behind these processes is useful not only for crop breeding and agriculture, but also for medical research. That is the view held by Professor of Plant Developmental Genetics…

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

‘If we don’t start talking about this, who else will?’ This is what Arjan Lankester, paediatrician/immunologist at the Leiden University Medical Center (LUMC) and Professor of Paediatrics, thought when it seemed that various extremely effective gene therapies for rare diseases would no longer be available…

Carina van den Hoven defended her thesis on 16 February 2017.

Humanities, Centre for Linguistics

PhD student Esmee Koedoot studied the underlying processes responsible for metastases in a dangerous type of breast cancer. She hopes to find new possibilities to fight the disease. In December 2019 she obtained her doctorate cum laude.

Leiden biologists have shown that a gene present in plants, animals and yeasts does play an important role in plants, although for years the gene was considered unimportant. It turns out the gene plays a crucial role in the development of vascular tissue in plants. Publication in Nature Plants on 11…

‘It was a discovery we did not expect,’ says Remko Offringa, professor of Plant developmental genetics. Today he publishes a new trait of a versatile gene in Current Biology: it makes the difference in plants between herbaceous and woody stem growth. A useful feature to prevent dehydration.

The way genes are folded determines their activity in our body. Leiden biophysicists are now the first to unravel this structure molecule-by-molecule. Publication on December 1st in Nature’s Scientific Reports.

In order to stop a whole range of diseases or disorders at their source, you would have to be able to switch certain genes on or off. Sebastian Pomplun wants to develop substances that can do this very precisely. For example, he wants to disrupt cancer processes and make cells produce an important missing…

A publication in Nature Plants by a team of Leiden biologists has received national and international media attention. The researchers can have annuals flower multiple times thanks to a particular gene they discovered.

Master's student Thalia Luden receives an NWO grant for her research proposal about a gene that brings flowering plants back into a growth phase. Companies in floriculture and vegetable seed breeding also contribute to the research.

An international team of researchers, involving members from the ERC Synergy project NEXUS 1492 based at the Leiden University, the Universities of Oklahoma, Copenhagen and York reveal challenges when studying ancient microbiomes in a recent issue of Scientific Reports.

What are the phylogenetic relationships among the members of speciation bursts?

In a publication in Science, Noam Zelcer from the Division of Biopharmaceutics describes a previously unrecognized pathway to regulate LDL-cholesterol levels. He is also able to modulate this pathway. This opens the possibility for complementing and improving the efficacy of statins: A class of drugs…

When we think about ancient Egypt, the first things that come to mind are usually mummies and sarcophagi. According to researcher and Rijksmuseum van Oudheden curator Lara Weiss, that impression is unjustified. She made an audio tour for the Rijksmuseum van Oudheden that focuses on living Egyptians…

The ancient Egyptians knew about marks as well as script. The New Empire (ca. 1550-1070 BC) in particular provides a rich harvest. The script has now been deciphered, but the same does not apply to the system of marks used at the time. Egyptologist Ben Haring has been awarded a subsidy by NWO from the…

The advent of script has never managed to eliminate the use of symbols. This is the finding of research carried out by Kyra van der Moezel on Ancient Egyptian identity marks. PhD defence 7 September.

Religion in the ancient world, and ancient Egyptian religion in particular, is often perceived as static, hierarchically organised, and centred on priests, tombs, and temples. Engagement with archaeological and textual evidence dispels these beguiling if superficial narratives, however. Individuals…

On the 23rd of June Arianna Sacco successfully defended a doctoral thesis and graduated.

Between 16 May and 4 June our first ‘Introduction to Ancient Egypt’ course took place with a group of highly motivated students.

An Ancient Egyptian System of Workmen’s Identity Marks

Do understudied animals contain hidden species?

Numismatic research of Roman coin hoards in the Netherlands. The use of numismatic sources is incorporated in Claes’s research project “Dialogues of Power”. This project aims to analyse the legitimising dialogue between Roman emperors and their Germanic legions during the so-called “crisis of the third…