941 search results for “protein” in the Public website
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Improving the treatment of pathogenic fungi. ‘The process is working, but not that well…’
Fungi germinating in the lungs of patients. Doesn’t sound too nice, does it? Luckily, humans can deal with this normally, and we are able to clear the infection before anything comes to harm. However, in people with health issues, Aspergillosis can cause a lot of damage, especially if the fungus becomes…
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Teaching synthetic molecules how to communicate
Although Sander Wezenberg just started working in Leiden in March this year, he already managed to win a Vidi grant from NWO. Inspired by nature, Wezenberg wants to bring synthetic molecules to life and teach them to communicate. But who exactly is Wezenberg and what drives him?
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Vici grants for 7 Leiden researchers
Seven Leiden researchers have been awarded a prestigious Vici grant by the Netherlands Organisation for Scientific Research (NWO).
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Three Leiden scientists receive NWO ENW-KLEIN grant for innovative research
The origins of Surinamese rice, a digital twin of the Earth and a large big-data project in the Chilean sky: three Leiden scientists receive an ENW-KLEIN grant for innovative, fundamental research.
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New professor of Biotherapeutics Delivery at LACDR
Matthias Barz has been appointed full Professor of Biotherapeutics Delivery at the Leiden Academic Centre for Drug Research (LACDR).
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Ten million euros for unlocking novel technologies in structural biology
The European Union has invested ten million euros in the so-called iNEXT-Discovery consortium. The goal of this new consortium is to enable European researchers to extend innovative structural biology research. The Netherlands Centre for Electron Nanoscopy (NeCEN) is also part of iNEXT-Disovery, which…
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Cancer vaccine packaged in minute particles
Leiden researchers have carried out successful tests using a new method of packaging a cancer vaccine in nano-particles. The new vaccine has induced a strong immune reaction in mice. The researchers believe that this method can make an important contribution to the treatment of cancer. Their findings…
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The most read stories of 2021 from Leiden University
Research into depression in children, Leiden alumni in the Dutch House of Representatives and an exceptional achievement by one of our students: what do this topics have in common? They are among our most read stories of 2021.
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Using fungi to produce renewable energy
Ebru Alazi ‘hacked’ an enzyme-producing system in the fungus Aspergillus niger in order to produce renewable energy more easily. She manipulated the fungus, making it produce more pectinases: enzymes mainly used in the food industry and in the production of renewable energy, such as biofuels. Promotion…
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Travelling through the body with graphene
For the first time researchers have succeeded in placing a layer of graphene on top of a stable fatty lipid monolayer. Surrounded by a protective shell of lipids, graphene could enter the body and function as a versatile sensor. The results are the first step towards such a shell, and have been published…
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Smallest-ever Leiden University logo
The logo of Leiden University, with letters as small as a bacterium. Researchers from LUMC and the Institute of Biology have created the smallest logo of our university ever produced. It is a piece of fun with a serious real-world application: the new microscope with which the logo was made allows scientists…
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Professor Ewa Snaar-Jagalska appointed professor in the field of cellular tumor biology
From the 11th of May Ewa Snaar-Jagalska has been appointed Professor in the field of cellular tumor biology within the Faculty of Science at the Institute of Biology Leiden. Her research focuses on the cellular tumor biology and human cancer modeling in zebrafish
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First discovery of methanol in a warm planet-forming disk
An international team of researchers led by Alice Booth (Leiden University, the Netherlands) have discovered methanol in the warm part of a planet-forming disk. The methanol cannot have been produced there and must have originated in the cold gas clouds from which the star and the disk formed. Thus,…
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How cool is LEGO®? Leiden physicists use it for ice cold research
Tjerk Oosterkamp's group is conducting what is perhaps the coldest research in the world. The researchers have cooled a sensor to below 2 millikelvin - almost as cold as absolute zero. This allows them to make extremely sensitive measurements. PhD candidate Jaimy Plugge helped build the setup: ‘We are…
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Converting CO2 to store renewable energy
Yuvraj Birdja converted CO2 to formic acid to store energy in a sustainable way, with different catalysts. With this new knowledge, scientists are a step closer in industrially converting CO2 to chemicals and fuels. This can help reduce CO2 emission and the greenhouse effect.
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Translating science into treatments of rare metabolic disorders
Leiden biotech startup Azafaros has successfully completed a funding round, raising 25 million euros of investments for developing treatments of rare metabolic disorders. The company holds exclusive license to a library of novel patented compounds discovered by experts from Leiden University.
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Plant-based diet can help unlock technology to harness huge CO2 removal
Bioenergy with carbon capture and storage (BECCS) is a promising method for removing carbon dioxide (CO2) from the atmosphere and simultaneously generating energy. Yet this method is controversial, as it may require a great deal of land and water. Researchers at Leiden University have now proposed a…
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Marc Baggelaar graduates cum laude on body’s own marijuana
PhD candidate Marc Baggelaar of the Leiden Institute of Chemistry (LIC) graduated cum laude on Thursday 6 April. His thesis on the endocannabinoid system in the brain is very comprehensive and of high quality, according to the jury. ‘A very talented young scientist, that definitely belongs to the top…
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Promising new technique to treat cancer receives NWO grant
Biological chemist Nathaniel Martin and his team received an NWO grant to examine how blocking a specific enzyme in our body, NNMT, could be helpful in the treatment of some cancers. Trials with mice have been promising, and together with the Netherlands Cancer Institute, Martin wants to take the next…
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Vidi grant for seven researchers from Leiden University
From malaria parasites as a vaccine to how top-level bureaucrats reach their decisions: seven researchers from Leiden University have received a Vidi grant from the Dutch Research Council (NWO). This 800,000-euro grant will enable them to develop their own innovative line of research over the next five…
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Medicine development is hunting magic bullets
Medicines are becoming increasingly precise and innovative, but at the same time increasingly expensive. With their innovations, it is up to universities to increase competition, thus causing prices to drop. This is what newly appointed Professor of Biomolecular Analysis Hubertus Irth argues. His inaugural…
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Why are plants not black?
All kinds of reasons have been put forward for why plants apparently fail to make maximum use of the available light. None of these reasons can explain why after two billion years of evolution they are not black, like industrial photovoltaic solar cells. Are we missing something?
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Using statistics to prevent the loss of blood donors
The Sanquin blood bank gathers data on every donation. Around 720,000 donations are made every year. ‘That generates a mountain of highly valuable data,’ says Leiden PhD candidate Marieke Vinkenoog.
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The chemistry behind cancer drugs: searching for fewer side effects
PhD candidate Dennis Wander searches for the best of both worlds. That is to say: a cancer drug that is effective and also has minimal side effects. To this end, he makes new molecules inspired by two existing medicines. And not without result: ‘We have created a new variant that is very promising.’…
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Nobel Prize for physics: 'Clear solutions are the best discoveries'
What does Leiden physicist Wolfgang Löffler think about the award of the Nobel Prize for physics to Arthur Ashkin, Gérard Mourou and Donna Strickland?
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Focus on kinetics for better drug development
Potential drugs that seem promising in the lab, but don’t show any activity in a person: they cost the industry an incredible amount of time and money. That’s why Indira Nederpelt focuses on a more efficient search for new drugs in her PhD, by determining the kinetics of a potential drug earlier on…
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Catena wins 2020 Sustainability Prize
The Sustainability Prize of the Leiden University Green Office and the Local Chamber of Associations has been won this year by student association Catena. In the shadow of the corona pandemic, Catena worked exceptionally hard to improve sustainability.
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Virtual preparation for lab practicals
How can we better prepare students for their practicals, so that they learn more from them? Marjo de Graauw and her colleagues want to renew science education. Together they will develop interactive teaching materials to introduce students to laboratory courses. They are receiving a SURF grant of €100,000…
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Will soap and sunlight solve the energy problem?
A consortium of international researchers comes with a unique solution to the energy problem. By mimicking photosynthesis, they aim to produce sustainable fuels out of sunlight, water, and CO2. Their secret? ‘Soap bubbles’, says Leiden chemist Sylvestre Bonnet, who is part of the consortium.
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Prehistoric hunters from the North Sea used human bones as weapons
Over the years, many spectacular archaeological finds have been washed ashore on the Dutch coast. Among these a large assemblage of barbed points made of bone and antler from the Mesolithic (11,000-8000 BC). The species used by Mesolithic hunter-gatherers to manufacture their barbed points remained…
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Gerard van Westen: ‘My first 100 days as a SAILS Professor in Leiden’
SAILS Professor Gerard van Westen tells us about his first 100 days 'in the office'.
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Small molecule prevents tumour cells from spreading
Leiden chemists, together with colleagues at the University of York (UK) and Technion (Israel) have discovered a small, sugar-like molecule that maintains the integrity of tissue around a tumour during cancer. This molecule prevents tumour cells from spreading from the primary cancer site to colonise…
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Science and business working together on affordable alternatives for antibiotics
Almost fifty scientists and twenty companies will be working on developing new antibiotics and alternatives for antibiotics use. NWO and the Ministry of Health, Wellbeing and Sport will together invest close to seven million euros in this research. Scientists from Leiden University and LUMC will be…
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Light and nanoparticles against cancer
Leiden PhD student Xuequan Zhou has designed a new promising molecule that efficiently kills cancer cells, but does not harm healthy tissue. The trick: the drug is only active when irradiated with light. Zhou’s new compound does this extra efficiently by cleverly self-organising into nanoparticles.…
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Fighting diseases with good bacteria
Researchers from the Institute of Biology Leiden have discovered how good intestinal bacteria regulate our innate immune system. This surprising discovery could make it possible to treat diseases related to inflammation, such as diabetes and colitis, with a cocktail of good bacteria. Publication in…
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How drugs work better when encapsulated in nanoparticles
Chemist Tobias Bauer discovered ways to improve drugs by encapsulating them. Packages with iron nanoparticles, for example, can stimulate immune cells. Bauer will receive his PhD on 9 June.
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Self-folding metamaterial
The more complex the object, the harder it is to fold up. Space satellites often need many small motors to fold up an instrument, and people have difficulty simply folding up a roadmap. Physicists from Leiden and Amsterdam have now designed a structure that folds itself up in several steps. Publication…
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Laura Heitman uses her expertise to fight cancer
Seven talented female scientists join the fight against cancer of the Oncode Insitute. Laura Heitman of the Leiden Academic Centre for Drug Research is one of the new Junior Investigators. ‘I hope to discover new druggable targets’.
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Erasmus+ grant for 13 exchange projects
Thirteen Leiden University exchange projects have been awarded an Erasmus+ International Credit Mobility grant. The total award of around 450,000 euros will enable 103 students and staff to go on an exchange.
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Pain relief without the high
Researchers at Leiden University led by Mario van der Stelt (Leiden Institute for Chemistry) have set ‘gold standards’ for developing new painkillers based on the medicinal effects of cannabis. Publication in Nature Communications.
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Artificial intelligence as the co-pilot for drug discovery
There are more molecules that could conceivably be candidate drugs than there are stars in the universe. How can we ever efficiently identify those molecules? Professor of AI and Medicinal Chemistry, Gerard van Westen: ‘I’m going to use artificial intelligence as the co-pilot to make an automated search.’…
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The body's own marijuana as inspiration for drug research
Endocannabinoids - the body's own marijuana - are promising departure points for drug research. Professor of Molecular Physiology Mario van der Stelt examines whether inhibiting their production can be a way to fight inflammatory brain disease and to combat obesity. Inaugural lecture 19 October.
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Ensnaring tumours in their own web
Erik Danen is looking at how to inhibit tumours that do not respond well to medicine – and he is making some headway. The Professor of Cancer Drug Target Discovery studies the interaction between tumour cells and their surroundings. Inaugural lecture on Friday 10 May.
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Alphabet of 140 puzzle pieces programs origami
How can a single origami crease pattern be folded into two precisely defined target shapes? Researchers at AMOLF and Leiden University have created an ‘alphabet’ of 140 origami ‘puzzle pieces’ that allows them to do just that, as described today in Nature Physics. This discovery could help in the construction…
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Researchers reveal how stem cells make decisions
Embryonic stem cells have the remarkable ability to develop into any type of cell. On their way to become for example a liver or a heart cell, they must repeatedly decide between alternative developmental paths. How they make these decisions is largely unknown. An international team of biophysicists…
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Major European research into microplastics in agricultural soils: grant for Thijs Bosker
Thijs Bosker, Associate Professor of Environmental Sciences at Leiden University College (LUC) and the Institute of Environmental Sciences (CML), has received funding as part of a large consortium to study the impacts of microplastics on agricultural soils. The project will receive 7 million euro of…
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Vici grant for Jeroen Codée: ‘I want to understand how sugars are formed’
Although sugars are widely used in biological and medical research, their synthesis is still badly understood. Jeroen Codée has received a Vici grant of 1.5 million euros for systematically studying the production of sugars. ‘I want to genuinely understand the reactions.’
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Chemical Proteomics revealed Poly(ADP-ribose) as a Potent for Biomolecular Condensates
Lecture
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3D modeling and RNA-based therapeutics for Dutch-type Cerebral amyloid angiopathy
PhD defence
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Functions and biosynthesis of a tip-associated glycan in Streptomyces
PhD defence