The Molecular Physiology group collaborates with both international public-private and academic institutions.

The imaging group focuses on bio-imaging, image analysis and visualization.

Bioactive Molecules is one of the four research themes of the Institute of Biology Leiden.

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

How can the development of constrictions in the blood vessels be reversed?

Lecture

German historian Katja Happe is the new Cleveringa Professor at Leiden University. She will give the Cleveringa Lecture on 26 November 2019. She conducts research into the persecution of the Jews in the Netherlands, and wrote the critically acclaimed book 'Veel valse hoop' (Much False Hope).

To mark its 75th anniversary, the Netherlands War Graves Foundation is publishing a portrait of a war victim every week this year. On 24 January the drawing of Irawan Soejono, a Leiden student and Indonesian resistance member, was unveiled at the Groenesteeg cemetery in Leiden, the place where Soejono…

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

LIACS organizes different lectures and colloquia, like the Florence Nightingale Colloquium, LCN2 Seminars, the Ada Lovelace Distinguished Lecture Series and the OTICS Colloquium.

Leiden biotech startup Azafaros has successfully completed a funding round, raising 25 million euros of investments for developing treatments of rare metabolic disorders. The company holds exclusive license to a library of novel patented compounds discovered by experts from Leiden University.

Lecture

Edith Schippers, Minister of Health, will be investing six million euros over the coming four years to boost research on new antibiotics. The programme will be set up by several different parties, including the Leiden Centre for Antimicrobial Research.

The war in Ukraine is leading not only to human suffering. Ukraine's cultural heritage is also experiencing the consequences of the war: museums are being bombed and 'Russification' in the occupied territories means children no longer learn Ukrainian. Researcher Evelien Campfens was commissioned by…

Conference

Research at the MCBIM group is comprised of the following research themes:

What is the role of cell wall-deficiency in the persistence of tuberculosis?

Supervisor: Natalia Ortiz Zacarías

Development of Comprehensive and High-throughput metabolomics techniques and Clinical applications of (pharmaco)metabolomics

Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.

The Skin Barrier and Vaccination group is led by Prof. Joke Bouwstra. One of the key functions of the skin is its barrier function, which is located in the uppermost layer of the skin, the stratum corneum. The stratum corneum consists of enucleated dead cells (corneocytes) embedded in a lipid matrix.…

From molecule, to cell, to organism. The high-level drug research at the Cell Observatory aimes at reducing the spread of cancer and developing new medicines for tuberculosis.

What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.

To address major societal challenges, research needs to go beyond the boundaries of traditional disciplines. We believe this starts with education. By exposing students to people from different scientific fields, they learn to deal with diverse perspectives and can broaden their horizons. Professors…

Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?

Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine.

The master’s specialisation Bio-Pharmaceutical Sciences and Industrial Pharmacy at Leiden University examines safety and quality control in the production of medicinal products, and prepares students for a career in Quality Assurance and Quality Control in the biotechnological and pharmaceutical ind…

Supervisor: Gerard van Westen

Leiden University seeks to bring knowledge, academic top talents, and resources from Leiden and China together in mutually beneficial joint research projects that are content-driven, based on existing excellent research.

The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.

Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

Urban riots, violent responses by police, drug-related assassinations, child abuse, bar fights: Violence is a core theme in today’s modern society.

Lecture

Her book ‘Veel valse hoop’ (Much False Hope) about the persecution of the Jews in the Netherlands was immediately hailed as a seminal work. German historian Katja Happe gave the Cleveringa Lecture on 26 November. She is fascinated by what makes people take a stand.

Pharmacologist Liesbeth de Lange has won the Lewis B. Sheiner Lecturer Award from the International Society of Pharmacometrics (ISoP). As Professor of Predictive Pharmacology she is working, among other things, on a mathematical model that can predict drug concentrations in the brain. On the occasion…

How wonderful would it be to use art, technology and science in Ukraine's recovery? Young Ukrainians currently residing in Poland get guidance to develop creative programmes and activities that can later be implemented. Leiden astronomers Pedro Russo and Kateryna Frantseva cooperate in the project.

Legal action relating to the situation in Gaza is now being taken in various countries and courts around the world. In a podcast for ‘NPO-Radio1’, Larissa van Herik, Professor of Public International Law, outlines what is gained from these cases and the relationship between law, activism and politic…

The mission in Uruzgan Province in Afghanistan was a formative experience for Dutch soldiers in which many lessons were learned. But most of those lessons have already been forgotten.

PhD defence

Research within COI@Leiden is clustered around two themes: sustainable justice and the courtroom as a social arena. Find out more about each of these projects by clicking on the links below.

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

Dr. Doris M. Jacobs, Lead Scientist at Unilever R&D, Wageningen, The Netherlands.

The currently available in vitro generated human skin equivalents resemble the human skin in many aspects. However, some essential barrier characteristics do not fully mimic the native barrier. Consequently, the human skin equivalents cannot be used for screening of drugs for skin penetration.

The Cell Observatory is run by several people some of which have multiple roles. To identify whom to contact for what issue please refer to the list below

Chiodo

Liposomes hold great promise for peptide-based personalized cancer vaccination, especially when administered intradermally. However, current liposome preparation methods are very time consuming (resulting in long development times per formulation), whereas personalized cancer vaccination requires very…

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.