2,483 search results for “center drug discovery initiative” in the Public website
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Meet the professor in The Hague
Leiden University's professors will be going to elementary schools again to teach about science and research. During the class discovery-based learning will be central. The professors will go to several schools in The Hague. The classes are part of the university's celebration of its 445th birthday…
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
PhD defence
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LED3 Chemical Biology Talk: Cyclic Peptides in Target Discovery
Lecture
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Antibiotic Discovery: From mechanistic studies to target ID
PhD defence
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
PhD defence
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Mycobacterial cell wall-deficiency and its role in the persistence of tuberculosis
What is the role of cell wall-deficiency in the persistence of tuberculosis?
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Vertebrate automated screening technology (VAST)
How can you use robots and automatic recognition of microscopic images to test the effect of drugs exceptionally quickly?
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Evaluation of synergistic effects of Chinese herbal medicine and natural compounds on cancers
What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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NeCEN
With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…
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Kv 11.1 (hERG)-induced cardiotoxicity: a molecular insight from a binding kinetics study of prototypical Kv 11.1 (hERG) inhibitors
Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)
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Development of an intradermal tuberculosis vaccine by combining dissolvable microneedle arrays and Mycobacterium tuberculosis antigen-containing
Mycobacterium tuberculosis (Mtb), the pathogen causing tuberculosis (TB), is the leader among all pathogens responsible for the most human deaths today and it is considered as one of the top 10 causes of death worldwide. There is an increasing occurrence of multidrug-resistant and even totally drug-resistant…
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
M. Danhof, Co-promotor: O.E. Della Pasqua
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Overview
Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
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Development of innovative engineered models for viral diseases
A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…
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Translational Immuno-Pharmacology
The Translational Immuno-Pharmacology group works on translating the efficacy of anti-infective therapy from preclinical (e.g. in vivo) to clinical, and is led by Rob van Wijk. Infectious diseases, such as tuberculosis, are in constant need of new therapies that work better, faster, and with less risk…
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High-Throughput Metabolomics
Development of Comprehensive and High-throughput metabolomics techniques and Clinical applications of (pharmaco)metabolomics
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Lectures at Science
From black holes to artificial intelligence and from drug research to data science: welcome to the fascinating world of the Faculty of Science. Our researchers, students and guests regularly give public lectures about their work. You are welcome to attend.
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Reversing cardiovascular diseases
How can the development of constrictions in the blood vessels be reversed?
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Research Facilities
Our Division has created and maintains the Visualisation Core Facilities of the LACDR. This is a multi-user facility offering basic and advanced microscopic techniques to scientists of the LACDR.
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The EPIC Alliance joins forces to combat antibiotic resistance
No, this isn’t about a Star Wars Alliance that wants to suppress The Resistance. Rather, the EPIC Alliance brings together scientific experts from seven countries to address the growing threat of antibiotic resistance. Leiden professor Nathaniel Martin is part of the 11-member consortium.
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Erik DanenScience
e.danen@lacdr.leidenuniv.nl | +31 71 527 4486
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Serkan AslanScience
s.aslan@lacdr.leidenuniv.nl | 071 5275919
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Hall of Fame 2022
In 2022, many of our staff and students won fantastic prizes and were awarded important research grants.
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Awards and Grants 2024
On this page you will find an overview of awards and prizes granted to our staff and students in 2024, as well as special appointments at Leiden University and other institutions.
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mRNA and Drug Delivery with Lipid-based Nanoparticles
PhD defence
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Bone and joint disorders: Screening and early clinical drug development
PhD defence
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pharmacology studies investigating novel formulations of dopaminergic drugs
PhD defence
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Glyco(proteo)mic Workflows for Cancer Biomarker Discovery
PhD defence
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Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
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Education
Studying linguistics at the Leiden University Centre of Linguistics (LUCL) is a challenging but rewarding experience. There are few places in the world where such a broad range of languages are studied from so many different perspectives.
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Top 450
What is your favourite thing about Leiden University?
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From data to discoveries: machine learning and optimization in space
Lecture
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Preventing or curing diseases with X-omics
In April, the X-omics initiative was granted 17 million euros from the Dutch Organization for Scientific Research. The subsidy is part of the National Roadmap for large-scale scientific infrastructure, intended to build or renew large-scale research facilities. What new insights will this investment…
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Deciphering the complex paramagnetic NMR spectra of small laccase
Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.
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Travelling patterns on Discrete Media
This thesis describes how complex and real-world relevant analytical solutions can be found starting from a simple Nagumo problem posed on one or two-dimensional lattices.
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Rob van Wijk has won the oral presentations of the National PhD Competition during the FIGON Dutch Medicine Days
He presented his PhD research entitled “Kick-starting drug development; translational systems pharmacology using innovative zebrafish experiments and advanced computational modelling”. During his presentation, Rob highlighted the advancements he made in using zebrafish as model in system pharmacolog…
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EUFEPS congres
EUFEPS Women in Pharmaceutical Sciences Award for Jara Bouma
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Erik Danen new Dean of the Graduate School of Science
The Graduate School of Science starts 2024 with a new Dean. The Faculty Council appointed Erik Danen for the coming four years. He succeeds Eric Eliel, who has held the position since May 2020.
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Predicting dementia
In the future, physicians may be able to identify dementia much earlier than they can today because a computer algorithm will be able to predict from brain scans how our memory is going to develop.
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Lifestyle and nutrition to combat diseases (of affluence)
We know this, but we don’t act on it: eat healthily, move more, address our stress levels and sleep well. Internist and Professor of Diabetology Hanno Pijl is fascinated by the effect that a healthy lifestyle can have on health. He researches how this lifestyle is achievable and satisfying, for patients…
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Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
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Glucocorticoid modulation of the immune response
Unraveling the immune-suppressive actions of drugs like prednisone.
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Infrastructure
An overview of our infrastructure at the SPP division:
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Search and rescue: tackling antibiotic resistance with chemistry
With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.
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Novel chemical tools for target validation in neuroinflammation
In what way can new tools and techniques be used to develop drug candidates for the treatment of neurological disorders?
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Advanced Pre-clinical Evaluation of the Guanidino Lipoglycopeptides: A Novel Family of Glycopeptide Antibiotics with Best-in-Class Potential
Can we make a better vancomycin?
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Development of organ-on-a-chip systems for translational and personalized medicine
We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.
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Imaging
The imaging group focuses on bio-imaging, image analysis and visualization.