PhD defence

PhD defence

PhD defence

Not experiments and lab coats, but computers and artificial intelligence: this year's Nobel Prize in Chemistry went to the inventors of the groundbreaking AI model, AlphaFold. This programme accurately predicts protein structures based on their genetic code—a crucial step in understanding biological…

No, this isn’t about a Star Wars Alliance that wants to suppress The Resistance. Rather, the EPIC Alliance brings together scientific experts from seven countries to address the growing threat of antibiotic resistance. Leiden professor Nathaniel Martin is part of the 11-member consortium.

For her bachelor’s thesis, Molecular Science and Technology student Madouc Bergers synthesized her own molecule that can inhibit the breakdown of sugars. Although most students do not even manage to make one building block, Madouc made three. Partly because of this, she has been nominated for the Science…

Book launch

On this page you can find information about previous CCLS events.

Violent conflicts and civil wars in Chad impede most rural households' access to food security, agricultural activities and access to essential services such as health care. In her dissertation, Nakar Djindil Syntyche denounces this issue. She obtained her PhD on 24 November.

The Institute of Security and Global Affairs (ISGA) of Leiden University contributed to the design and teaching of modules of this year’s edition of the Ministry of Defence’s ‘International Military Cooperation Course Africa’.

A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Enabling volume-restricted metabolomics using next-generation microscale analytical tools.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…

Key publications of the Cancer Drug Target Discovery group

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

How can you use robots and automatic recognition of microscopic images to test the effect of drugs exceptionally quickly?

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

The Translational Immuno-Pharmacology group works on translating the efficacy of anti-infective therapy from preclinical (e.g. in vivo) to clinical, and is led by Rob van Wijk. Infectious diseases, such as tuberculosis, are in constant need of new therapies that work better, faster, and with less risk…

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

Mycobacterium tuberculosis (Mtb), the pathogen causing tuberculosis (TB), is the leader among all pathogens responsible for the most human deaths today and it is considered as one of the top 10 causes of death worldwide. There is an increasing occurrence of multidrug-resistant and even totally drug-resistant…

M. Danhof, Co-promotor: O.E. Della Pasqua

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

From nanoparticles to colliding ice planets and from biological origami to new x-ray scanner techniques: this year again, our scientists have made wonderful discoveries. From the largest numbers to the smallest molecules and from the oldest galaxies up to the latest algorithms, take a look at each institute's…

Inaugural lecture

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

How can new compounds relieve cancer patients of severe side effects?

Our Division has created and maintains the Visualisation Core Facilities of the LACDR. This is a multi-user facility offering basic and advanced microscopic techniques to scientists of the LACDR.

Russian Cellist and ACPA researcher Maya Fridman is organizing many benefit events together with Russian and Ukrainian musicians to raise funds for Giro 555 for Ukraine.

For too long the Dutch collective memory has judged the Jewish Council too harshly. This perspective needs to be adjusted, Bart van der Boom argues in his new book ‘De politiek van het kleinste kwaad’ (lit. ‘The Politics of the Lesser Evil’).

A consortium of research groups, including that of LACDR professor Erik Danen, will use an NWO Perspective grant of nearly five million euros to build a universal standard for organ-on-chip models. They aim to stimulate the application of these chips in the biomedical and pharmaceutical industry. Danen…

Before patients can take a pill, scientists often spend years in the lab developing and testing a candidate drug. That often includes experiments with laboratory animals. As head of the rodent facility, Ilze Bot and her colleagues ensure that these experiments are conducted in an ethically responsible…

Erik Danen is looking at how to inhibit tumours that do not respond well to medicine – and he is making some headway. The Professor of Cancer Drug Target Discovery studies the interaction between tumour cells and their surroundings. Inaugural lecture on Friday 10 May.

Medicines do not follow the one size fits all principle, because genetic differences can influence their efficiency. That is what research by PhD candidate Julia Hillger shows. She defends her PhD dissertation Take it Personal on Thursday 7 December.

At the Faculty of Archaeology, we investigate the development of human societies worldwide, from the earliest beginnings to modern times. We also study the heritage of mankind, which evokes this deep history, and which connects with, and informs, contemporary society.

Conference

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

Unraveling the immune-suppressive actions of drugs like prednisone.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…

We know this, but we don’t act on it: eat healthily, move more, address our stress levels and sleep well. Internist and Professor of Diabetology Hanno Pijl is fascinated by the effect that a healthy lifestyle can have on health. He researches how this lifestyle is achievable and satisfying, for patients…

In the future, physicians may be able to identify dementia much earlier than they can today because a computer algorithm will be able to predict from brain scans how our memory is going to develop.

How can zebrafish research help to understand and fight human cancer?