In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

The first photo of a black hole and measuring anxiety in the brain... From 13 until 22 May we're serving a free slice of science with your pizza.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Artificial photosynthesis aims to produce fuels from solar energy using chemical processes. In semi-artificial photosynthesis, a hybrid approach is taken using both chemical and biotechnology approaches. We aim to develop hybrid systems between light-harvesting nanoparticles and redox-enzymes (oxidoreductases)…

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

MT3 is a globally unique programme led by professors and reference authors that cover the most up-to-date knowledge possible in the area of Transfusion Medicine and Cellular and Tissue Therapy. It provides access to high quality knowledge and skills via a completely online system.

Key publications of the Cancer Drug Target Discovery group

Cationic peptide amphiphile nanoparticles are employed for co-delivery of immune modulator CpG and antigen. This results in better targeting to the antigen presenting cells and eliciting strong Th1 response, which is effective against the intracellular pathogens.

High throughput microscopy

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

John van Noort

Analysis of drug adversity

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

In the Life Science & Technology (LST) degree programme you study the functioning and applications of the living cell: the building block of all plants, humans, animals and micro-organisms. This can be your contribution to a clean and healthy world.

The work done by SUMO proteins in the cells of our body is of vital importance. Molecular cell biologist Alfred Vertegaal has been studying these proteins for nine years, first with a Veni subsidy and then with a prestigious Vidi subsidy.

Erik Danen is looking at how to inhibit tumours that do not respond well to medicine – and he is making some headway. The Professor of Cancer Drug Target Discovery studies the interaction between tumour cells and their surroundings. Inaugural lecture on Friday 10 May.

PhD defence

PhD defence

PhD defence

On 12 January 2018 Jorrit Rijpma, associate professor of the Europa Institute and Jean Monnet Professor, held the yearly Meijers lecture. In the well-attended lecture he spoke on the topics of his Jean Monnet Chair on Mobility and Security: the aftermath of the refugee crisis and the effects on free…

In the framework of his Jean Monnet Chair on Mobility and Security, Jorrit Rijpma has given a series lectures on EU migration and asylum law to the students of the interdisciplinary master on Governance of Migration and Diversity. This interdisciplinary master was set up in the framework of the Leiden…

On 9 February students of the Master in European Law visited the new headquarters of Eurojust, one of the EU’s agencies for judicial cooperation in criminal matters based in The Hague.

Lecture, also on line with Zoom

Psychology Lab on Wheels is available for rent for your on-site research. What does the mobile lab look like? What are the requirements? How do you make good use of the mobile lab?

This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Science with the Ethiopian Space Science and Technology Institute.

This is an Erasmus+ International Credit Mobility project of the Faculty of Science and Leiden University College with four universities in Nigeria.

Postcolonial Displacements explores the multiple ways in which migration in South Asia contributes to the imagining, questioning, subverting and reframing of territories, nations and communities. The project focuses on the contested fringes of the politically divided South Asian subcontinent, across…

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

Seminar

Resilient Diversity: the Governance of Racial and Religious Plurality in the Dutch Empire, 1600-1800

The university aims to expose all students to sustainability topics and issues that are relevant to their field during their time studying here. Students are educated to become academic professionals with the necessary knowledge and skills to contribute to the sustainability transition.

This programme starts from the idea that cultural discourse is one of the main engines of intellectual history and the history of ideas.

Reference management software is software that enables scholars, researchers, and academics of all types to capture and use citations when creating their bibliography. These programs allow you to import citations from various databases and websites, create and organize bibliographies, and format article…

Many countries and regions face a wide variety of challenges resulting from migration and mobility. Solutions that have been formulated range from policies and regulations for immigration, to education and stimulating social participation, to restructuring the welfare state. These challenges and policies…

This is an Erasmus+ International Credit Mobility project of Leiden University with the American University in Cairo.