What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?

In 2021, the KABK, KC and ACPA established a joint research platform, called the Platform for Arts Research in Collaboration (PARC). How did PARC move forward the last year?

Economies worldwide are increasingly interconnected; trade in raw materials and semi-finished products is increasing. Many products we use in the Netherlands originate abroad, and many products we make in the Netherlands are destined for other countries. Almost all countries around us participate in…

A political-legal study of rights invocation by pollution victims in China and Indonesia

A splendid milestone after seven years of collaborative research on the sustainable development of the Indonesian economy. Professor of Industrial Ecology Arnold Tukker has been appointed as a guest professor at the Faculty of Economics and Business of Universitas Padjadjaran (UNPAD) in the Indonesian…

Linguist Ingrid Tieken-Boon van Ostade retired in July, but is pressing on regardless with her languages in The Hague project. An online tour of her Hague Proverbs launched recently and Tieken also has academic publications in the pipeline.

Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

Do you practice public engagement? The International Astronomical Union (IAU) has just released a unique set of open-source materials designed to be used in public engagement training workshops.

Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?

This longitudinal study is focused on neurodevelopmental problems in young children with XXY, XXX and XYY, aged 1 to 6 years.

Leonie Vreeke is ready to start a new 5-year project to develop a stepwise treatment specific to very shy young children. Her proposal was granted by ZonMw with nearly € 600.000,-. A PhD student and a research assistant will be appointed to execute this project, together with societal partners such…

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How can zebrafish research help understanding human diseases?

How do poor and disadvantaged Indonesians address the injustices they face in daily life and how can their situation be improved?

A celebration was held in the Tabú restaurant: Mark Rutgers, Dean of the Faculty of Humanities, was presented with the first copy of LEAP, a journal where Humanities master’s students can prepare for an academic career by publishing articles themselves.

It is a familiar phenomenon: you ask the assistant on your phone to call your mother, but it calls a friend instead. Tom Kouwenhoven, PhD student in the SAILS programme, investigates how humans and Artificial Intelligence (AI) can better communicate with each other, so that these kinds of situations…

It is a familiar phenomenon: you ask the assistant on your phone to call your mother, but it calls a friend instead. Tom Kouwenhoven, PhD student in the SAILS programme, investigates how humans and Artificial Intelligence (AI) can better communicate with each other, so that these kinds of situations…

In February 2023, the International Institute of Air and Space Law and the Kalshoven-Gieskes Forum for International Humanitarian Law organised a seminar on the topic of 'The optimisation of the use of satellite information in the humanitarian domain – Legal and space-related developments' at Leiden…

In recent days and weeks, experts have been falling over themselves to point the finger at the main culprit in the Dutch child benefits scandal. Although this debate is fascinating, equally important are the broader lessons to be drawn from the scandal in relation to constitutional and administrative…

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

Recently, the PhD thesis of Lolu Danso Eweje appeared entitled ’Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin’.

How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?

How do macrophages and neutrophils contribute to metastatic onset?

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Can we enhance the capacity of host immune cells to kill mycobacteria via production of reactive nitrogen species?

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?

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What is the function of the insect serosa?

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Publication by: Anouk Wezel, Sabine Welten, Wida Razawy, Max Lagraauw, Margreet de Vries, Eveline Goossens, Martin Boonstra, Jaap Hamming, Ekambar Kandimalla, Johan Kuiper, Paul Quax, Yaël Nossent and Ilze Bot. Annals of Surgery. 2015;262:841-848.

We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

Conference

Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?

The 20th anniversary of the Lorentz Center will be celebrated on 28 June 2017 with the opening of an exhibition in the Oude UB. For two decades already, the Center has been a place of retreat for groups of international academics who want to explore a single issue.

Mathematical biologists from Leiden have developed a model that helps to explain how the spine and vertebrae, among other things, form during embryonic development. The same process, the other way around, plays a key role in cancer metastasis. Publication in iScience.

From 1 January 2017, Professor of neurocognitive developmental psychology Eveline Crone has been appointed member of the Social Sciences Council of the Royal Netherlands Academy of Arts and Sciences (KNAW).

On 16 January 2018, the Asia-Pacific Research and Training Network on Trade (ARTNeT) published Fengan Jiang's (Richard) working paper entitled 'Export restrictions and policy space for sustainable development: Lessons from trends in the regulation of export restrictions (2012-2016)''.

What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?

A team of five PhD students from Leiden University is in the running for first prize in the Pharmacometrics Skills Competition. In a drug development simulation, they apply their mathematical pharmacological skills to solve clinical problems. On 24 March they will compete in the finals in Orlando, F…

Which immune mechanisms are involved in host defense against Staphylococcal infection?

Dear friends of the NVIC,

TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.

On January 24 Professor Annemarie Meijer and Dr Sander Wezenberg received a NWO grant for their research. The grant was awarded within the Open Competition Domaine Science-M programme and is intended for innovative research areas that can form the basis for the research themes of the future.

How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic waste-products and matrix-degrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?

What is the role of cell wall-deficiency in the persistence of tuberculosis?

The project’s overall goal is to improve Indonesia’s environmental legal framework and its implementation by strengthening the regulatory capacity of the government, and by enhancing the capacity of CSOs and scholars to hold the government accountable for its regulatory performance.