941 search results for “protein” in the Public website
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Combined technique measures nanostructures ten times better than before
Researchers at Leiden University and TU Delft have combined two techniques that are used to measure the structure of biomolecules, creating a method that is ten times more sensitive.
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‘Ultimately, the goal is to develop antibiotics for tuberculosis with a lower risk of resistance’
Tuberculosis stands as one of the most lethal infectious diseases worldwide. A significant challenge in combatting tuberculosis lies in the emergence of antibiotic resistance triggered by genetic alterations, commonly known as mutations. These mutations can diminish the responsiveness to antibiotics,…
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Leiden alternative to plastic microparticles wins second prize in European student competition
A team of students from Leiden and Groningen took the second prize at the European final of the BISC-E sustainability competition. Last June, the team had already won the Dutch finals. The students came up with ‘Suckerspheres’, a natural alternative to the plastic micro-particles that are still frequently…
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In memoriam professor Mathieu Noteborn
On the 5th of April 2019 our dear colleague and friend Professor Dr Mathieu Noteborn has passed away. In January of this year he was diagnosed with bowel cancer. He underwent surgery followed by chemotherapy, and despite the invasive nature of this therapy things were looking up. True to his optimistic…
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Three LUF grants for talented Leiden Science researchers
Fighting against cancer, antibiotic resistance and disposable plastics: Ahmed Ali, Fredj Ben Bdira, and Valerio Barbarossa receive a LUF grant for their innovative and socially relevant research. These grants for academic talent are often an important step towards grants by NWO and other grant insti…
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Discoverer of the Year bridges science and medicine
Fascinated by science since high school, Alireza Mashaghi Tabari is driven to explore new ways of thinking in medicine. With a strong academic network, he educates students and gives public lectures. For his research at LACDR, he won the C.J. Kok Public Award 2018, making him the Faculty of Science's…
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Vici for Sylvestre Bonnet: new light on cancer therapy
Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.
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The quest for more antibiotics
Streptomycetes are similar to moulds, but these bacteria live in the soil. They are very popular in biotechnology because they produce a great many antibiotics and enzymes. Gilles van Wezel will be using his Vici subsidy to study ways of increasing their production.
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Counting Molecules in Living cells
Biophysicist Rolf Harkes has developed a microscope to optically localize individual molecules in living cells. It improves monitoring of diseases like cancer and Parkinson’s at the cellular level. Defende PhD thesis on t13 January 2016.
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Vici grants for four Leiden researchers
Four Leiden researchers have been awarded a prestigious Vici grant by the Netherlands Organisation for Academic Research (NWO).
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EU awards 18 million euros for research into new antibiotics
An international consortium of research groups is aiming to develop novel antibiotics against the tuberculosis bacteria and two other deadly bacteria. The European Union has awarded a total of 18 million euros to the RespiriTB and RespiriNTM projects. Researchers from the Leiden University Medical Centre…
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Why arteriosclerosis looks like an autoimmune disease
Arteriosclerosis bears great similarities to autoimmune diseases. Researchers from Leiden University show this in a new study they published in the renowned scientific journal Nature Cardiovascular Research. 'This discovery suggests that treatment methods for autoimmune diseases might also be effective…
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Remko Offringa appointed Professor in the field of Plant Developmental Genetics
Remko Offringa has been appointed Professor in the field of Plant Developmental Genetics within the Faculty of Science at the Institute of Biology Leiden (IBL) from the 1st of April 2017. Offringa’s research focuses on the role of the plant hormone auxin in controlling plant growth and development,…
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Cum laude physicist Tom O’Brien to research quantum chemistry by quantum computers
With defending his thesis ‘Applications of topology to Weyl semimetals and quantum computing’, the Leiden theoretical physicist Tom O'Brien has gained the rare 'cum laude' qualification. The freshly minted PhD has started a five year research programme on quantum algorithms for quantum chemistry, funded…
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European collaboration shines a light on enzyme discovery for industry
A European consortium has provided a disruptive technological breakthrough to allow the discovery and characterization of novel enzymes for industrial biotechnology. The technology will open the way to more efficient industrial processes such as in the biofuel, animal feed and paper and pulp industr…
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Altering the appearance of macrophages to prevent atherosclerosis
It might be possible to prevent atherosclerosis by changing the appearance of macrophages, cells of the immune system that for example digest foreign substances. In her PhD dissertation, Baoyan Ren examined several ways to do so.
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Folded DNA unravelled
Leiden physicist Maarten Kruithof has discovered how our DNA is infallibly able to fold itself and to unfold again. In his dissertation he demonstrates how DNA is folded in a single long, very flexible spiral.
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Two young female Leiden researchers join Oncode
The Oncode Institute is a new international network organisation that focuses on making sure that new scientific findings on cancer are implemented in patients as rapidly as possible. Two young female researchers at Leiden University have been selected to join Oncode: Laura Heiman (Leiden Academic…
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VICI for Mario van der Stelt
For his ground-breaking chemical biological research, a VICI-grant has been awarded to Mario van der Stelt, professor of Molecular physiology at Leiden University. In a new research line, he aims to discover binding sites for new medicines against inflammations in the brain.
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ERC grants for four Leiden scientists
Four scientists from Leiden University have each been awarded a Starting Grant by the European Research Council (ERC). This grant, worth up to two million euros, gives researchers the opportunity to head up a research team for five years.
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Sebastian Pomplun joins Oncode Institute to accelerate breakthroughs in cancer research
Sebastian Pomplun manages to reach proteins with drugs even where this was thought impossible. That is why he and his research group have been allowed to join Oncode Institute. With nine others, he had been selected from 72 applicants to contribute to Oncode Institute's mission: to accelerate breakthroughs…
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BRAIN appoints University of Leiden as partner for BEC-Enabled production strain development
BRAIN Biotech and the Leiden University will jointly develop an Aspergillus based production strain with high yield and thus contribute to a bio-based circular economy. The cooperation is based on BRAIN´s molecular tool BEC.
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Mechanism MRI amplifying agents explored
Special amplifying agents can make MRI scanners and NMR techniques hundreds of times more sensitive. Leiden physicists have now found a method to test their efficiency. More sensitive MRI scans could for example improve our understanding of cystic fibrosis or Parkinson’s disease. Publication in PCCP…
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New insights into Neandertal knowledge from the mass-spectrometry analysis of plastic containers
The analysis of protein residues extracted from the storage containers of circa 50,000 year old bone-tools reveals Neandertal strategic selection of bovid ribs to make some of their “lissoirs”.
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Special nanoparticles for cancer therapy! Will you help?
Developing a better treatment for patients with head and neck cancer, that is what Binanox, The 2022 iGEM Leiden team, want to achieve. They hope to raise at least 10,000 euros for this cause. Support their crowdfunding campaign today.
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Innovation in treatment and care
Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…
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Education highlights 2023
From educational adventures in the tropics, students building software for real customers, to bacteria that degrade plastics. Scroll through our highlights on educational innovation and the achievements of our students.
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Working at the Faculty of Science
Working for a top faculty? Discover the vacancies at the Faculty of Science and apply immediately.
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Research methods
Because we cannot directly ask babies about what they know or what they are thinking about, we must find smart and baby-friendly ways to figure it out! Below you can read about the different methods that we typically use in our studies.
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Glucocorticoids in zebrafish
A novel in vivo model system for studies on glucocorticoid resistance
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Key publications
Selected publications of the Cardiovascular and Metabolic Therapeutics group.
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Bio-organic Synthesis
The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…
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Research projects
The research of the Van Eck Group focusses on 3 interconnected research lines: 1) Identification and therapeutic targeting of key pathways/regulators in macrophages essential for prevention of atherosclerotic lesion development or stimulation of regression of existing lesions, 2) Atherosclerosis as…
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Science and society Faculty of Science Leiden
We also conduct research to make meaningful contributions to society. For instance, by talking about our research, contributing to community projects or by inviting people to help us with our research. Scroll down and discover how Science and Society can mutually reinforce each other.
- Jan van Ruitenbeek Lab - Atomic and Molecular Conductors
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Vision and Mission
The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.
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International Symposium on Circuit Topology Organized by Leiden University
For the third consecutive year, LACDR organized the international symposium on topology, Circuit Topology III, on November 29, 2023. The event aimed to bring together experts from diverse fields, including mathematics, computer science, physics, chemistry, and biomedical sciences, to discuss cutting-edge…
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EIC Pathfinder Challenge grant for research into autoreactive B cells in cardiovascular disease
At the division of BioTherapeutics, Amanda Foks, Bram Slütter and Ilze Bot have obtained a €4 million research grant from the HORIZON 2022 EIC Pathfinder Challenge “Cardiogenomics”, entitled “B-specific: B-cell related gene and protein markers with prognostic and therapeutic value for CVD”.
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KNMP student prize for Bio-Pharmaceutical Sciences student Jacqueline Gerritsen
During the congress of the Royal Dutch Association for the Advancement of Pharmacy (Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie, KNMP) Jacqueline Gerritsen, former student Bio-Pharmaceutical Sciences at Leiden University, was awarded the KNMP student prize.
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Bart Lenselink will represent LACDR at the FIGON Dutch Medicines Days
Drs. Bart Lenselink won the oral presentation at the LACDR Spring Symposium with his presentation “Predicting Drug Potency”.
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Hermen Overkleeft wins the 2015 Jeremy Knowles Award
Prof. Hermen Overkleeft has been awarded the 2015 Jeremy Knowles Award of the Royal Society of Chemistry for his innovative and insightful development of activity-based protein probes for the imaging and identification of enzymes in health and disease.
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Discoverer of the Year 2014: Annelien Zweemer
Former PhD student Annelien Zweemer was granted the C.J. Kok Award 2014, also known as “Discoverer of the Year”. A festive ceremony took place at the Faculty’s New Year’s reception on January 6, 2015.
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Eleven Vidi grants for Leiden
NWO has awarded eleven Leiden researchers a Vidi grant of 800,000 euros. The research subjects range from Cicero and muscle dystrophy to the archaeology of bogs.
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Two young chemists win Marie Curie subsidy
The Leiden Institute of Chemistry (LIC) is to be joined by a further two talented young chemists. Bela Bode and Michele Pavanello have each won a Marie Curie subsidy. Bode will be studying electron transport in photosynthesis and Pavanello will be using computer models to study charge transport in large…
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Vidi grants for eight researchers from Leiden University
Eight scientists from Leiden University have been awarded a grant by the Dutch Research Council (NWO). With this Vidi funding, the researchers can set up an innovative line of research and further expand their own research group over the next five years.
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Artificial intelligence helps in the search for new antibiotics
With the search for new antibiotics becoming increasingly urgent, artificial intelligence offers valuable help. Smart software developed by Leiden PhD candidate Alexander Kloosterman searched genomes of bacteria and found clusters of DNA that code for proteins that have an antibiotic effect. ‘This new…
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Probing the secret forces of pericytes
Leiden researchers found a way to measure the tiny forces exerted by pericytes, one of the most elusive, hard to research cell types, which occur in tiny blood vessels. Building on this fundamental science, researchers may eventually find treatments for medical conditions like ischaemia.
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Three new professors for the Leiden Institute of Chemistry
With Sylvestre Bonnet, Jeroen Codée and Remus Dame, the Leiden Institute of Chemistry (LIC) will be getting no less than three new professors. Bonnet will become professor in Bioinorganic Chemistry, Codée professor in Organic Chemistry and Dame professor in Molecular and Cellular Biochemistry.
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Female Researchers in the Spotlight for Physics Ladies Day
On Friday 28 October, Leiden University organized its annual Physics Ladies Day for female high school students. To mark this festive day, we put the spotlight on four female researchers, who talk about their experiences in physics.
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Three Leiden Science projects receive computing time on national supercomputers
A night sky of more than 40 petabytes in size, simulating young star clusters and understanding how the body inhibits viruses: three Leiden projects have received computing time on one of the national computer systems.