Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.

Discovery of metastasis promoting candidate drug targets

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

The group Theoretical Physics of Life Processes, led by Helmut Schiessel, focuses on the physics of chromatin, the DNA-protein complex that fills the nuclei of eukaryotic cells.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

The first global safety summit on Artificial Intelligence is a fact. Prime Minister Sunak organised the conference because he believes that the issues related to AI can only be dealt with by governments. But the real issue with AI remained undiscussed at the summit, Reijer Passchier claims in Dutch…

The ‘Leids Universiteits Fonds’ (LUF) award grants to research and educational project in various academic fields once a year. This year, Honorata Mazepus, Tanachia Ashikali, and Jaroslaw Kantorowicz of the Faculty of Governance and Global Affairs were three of the recipients of such a grant.

Massive science communication projects should be based on strong and relevant science cases. They should engage with a large number of stakeholders, not only in research, academia, policy, funding and governance but also in less traditional communities, such as the arts field. This is the outcome of…

Maureen Kuijs, third-year BA Korean Studies student, is one of the students that received the 2020 Global Korea Scholarship this year. With this scholarship, Maureen can pursue a Master's degree in Korean Language and Literature at Yonsei University, receiving financial support from the South-Korean…

Leiden University has taken eighth place in the UI Green Metric, a global sustainability ranking for universities. Over 900 universities from all round the world participated in the ranking.

PhD defence

This seminal volume covers the entire global history of urbanization since the rise of cities in Mesopotamia in the 6th millennium BC. Leiden historians Wim Blockmans, Leonard Blussé, Luuk de Ligt and Leo Lucassen contributed survey and thematic chapters.

More than 130 countries, including the Netherlands, have decided to introduce a minimum corporate tax rate of 15 percent. The plan would lead to 125 billion euro in extra tax revenue globally.

On Monday 8 April, a high-profile guest visited Leiden Law School. Dutch Minister for Foreign Trade and Development Cooperation Geoffrey van Leeuwen gave a powerful speech to students about defending our interests in all current global developments.

A political-legal study of rights invocation by pollution victims in China and Indonesia

On Human Rights Day 2024, the International Court of Justice is charged by the General Assembly with delivering an Advisory Opinion asking, in effect, what does the climate crisis imply for the rights of vulnerable states and people? Researcher Jens Iverson shares his thoughts on this event.

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

Study information, Online Experience

On 21 March 2024, the ‘learners’ at Wolfert Bilingual in Rotterdam were not teenagers, but some 180 teachers and teacher educators from around the Netherlands and beyond. Those delegates were bound by a common interest in exploring and engaging with teaching and learning in linguistically and culturally…

Three quantum-safe cryptography methods have been standardised for worldwide use since this week. Léo Ducas co-designed the two primary PQC methods selected for this standardisation. Ducas is part of the Cryptology group at Centrum Wiskunde & Informatica (CWI) and is also professor of Mathematical cryptology…

Annetje Ottow, president of the Executive Board of Leiden University, has been the new chair of the Leiden-Delft-Erasmus (LDE) strategic alliance for just two months. What does she want to achieve during her two-year chairmanship?

On 8 October, the Independent Expert, Prof. Manfred Nowak, leading the UN Global Study on Children Deprived of Liberty presented his report to the UN General Assembly. The presentation of the final report is set for 19 November 2019, at the occasion of the 30th anniversary of the UN Convention on the…

An organized overview of the current global fungal diversity, that is what Irene Martorelli and colleagues try to achieve with the new MycoDiversity Database (MDDB) she builds in collaboration with Naturalis Biodiversity Center. The new database will make it easier and quicker to observe which fungi…

Study information, Webinar

Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.

Plant Sciences' contribution to the Host-Microbe Interactions research theme is to dissect how microorganisms and microbiomes interact with the plant host and the insects on those plants, and how these insights may be harnessed to improve plant growth and health, by steering microbiome composition and…

What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?

The research master's specialisation Developmental Psychology consists of five main parts: the general courses, the specialisation-specific courses, the elective courses, a research internship and a thesis.

How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.

PhD defence

The Dutch and English East India Companies were formidable organizations that were gifted with expansive powers that allowed them to conduct diplomacy, wage war and seize territorial possessions. But they did not move into an empty arena in which they were free to deploy these powers without resista…

The Role and Effectiveness of the G20. In this article, published in The Changing Global Order part of the United Nations University Series on Regionalism book series, author Jaroslaw Kantorowicz discusses the evolution of the G20.

Promotor: Prof.dr. T. Schmidt, Co-promotor: Dr. ir. S. J.T. van Noort

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).

Promotores: J.C. van Houwelingen, S.A. van de Geer

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)