The Collective Experience of Empathic Data Systems (CEEDs) consortium developed novel integrated technologies that support experiencing, analysing and understanding of very large datasets.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

The Saalian archaeological record at Maastricht-Belvédère (the Netherlands).

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Peter Flach is Professor of Artificial Intelligence at the University of Bristol. An internationally leading scholar in the evaluation and improvement of machine learning models using ROC analysis and calibration, he has also published on mining highly structured data, on knowledge-driven and explainable…

Nanoparticles exhibit a number of adjustable properties, e.g., their size, shape, and surface and core chemistry, which can be further diversified with different functional moieties. This opens a broad field for application in diagnostic and therapy. In this respect, the use of a polymeric hybrid material,…

Since June this year, the ACPA PhD-council has been organising a monthly forum for doctoral students across ACPA's PhD-programmes.

On the 5th of May 2016, the second annual conference of the Leiden Center for East African Law (LEAC) took place at the East African Community headquarters in Arusha, Tanzania. The Conference was organized on the occasion of Europe Day with the generous support of the EAC, the EU delegation to EAC and…

PhD defence

PhD defence

PhD defence

Cancer is one of the main causes of death in the Netherlands. Leiden researchers are working to improve the treatment of different types of cancer in order to increase the patient’s quality of life. A better understanding of how cancer develops will make it possible to deliver personalised and precise…

Promotor: Prof.dr. T.J. Aartsma, Co-promotor: R.N. Frese

According to the LUMC, patients experience 30% fewer serious side effects when medication doses are tailored to their DNA.

How can Staphylococcus aureus bacteria subvert the host immune system?

More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.

In 2020, Leiden University launched its stimulated interdisciplinary programs, including one focused on regenerative medicine.

A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…

How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

A COVID-19 vaccine that specifically instructs the immune system to produce T-cells rather than antibodies is shown to provide good protection in a mouse model, Leiden University Medical Center (LUMC) researchers report in Nature Communications. According to them, the alternative vaccine may offer a…

Prof. Zangenberg came to Leiden in 2006 as Professor for New Testament and Early Christian Literature and is now Chair for the History and Culture of Ancient Judaism and Early Christianity.

Do you recall all those drugs that were hastily proposed as potential treatments for COVID-19? In the event of a future pandemic, the goal is to offer an effective treatment more quickly and efficiently. To achieve this, a team led by Coen van Hasselt is developing a platform that can speed up the process…

Toxys, Leiden University and Leiden University Medical Center have agreed immediately to commercialise and also develop further the ToxProfiler technology invented at the two institutions. ToxProfiler allows for rapid toxicity hazard identification of novel and existing drugs, chemicals, and other substances.…

The Ministry of Health, Welfare and Sport (VWS) submitted Pharma-NL to the R&D program of the National Growth Fund, a 20 billion euro program of the Dutch government that intends to create long-term economic growth in The Netherlands.

Indira Nederpelt was elected as the winner of the Young Investigator Award for best oral presentation titled ‘’Kinetic characterization of clinically used GnRH peptide agonists’’.

The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?

Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.

Festival

On 18 January 2020 Christa Tobler took part in a fireside talk on the above-mentioned topic, together with European Parliamentarian Andreas Schwab, Swiss Parliamentarian Eric Nussbaumer and German Ambassador to Switzerland Riedel.

PhD defence

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

On Friday the 29th of October, LACDR presented highlights of its research and teaching program during an online Lunchtime Talk session at the European Medicines Agency (EMA).

The Phantom of the Ego is the first comparative study that shows how the modernist account of the unconscious anticipates contemporary discoveries about the importance of mimesis in the formation of subjectivity.

This book covers the story of Greece and its central role in our understanding of European civilization, from the Palaeolithic era (400,000 BP) to the early modern period (1950 AD).

Gerard van Westen (LACDR/division of medicinal chemistry) has been awarded with a VENI grant from NWO, the Dutch Research Council.

A cancer pill, preferably without severe side effects, is something we’d all welcome. Is it a matter of time before such a pill is a reality? We put this question to three Leiden researchers and asked how they themselves are contributing to new cancer treatments.

Embryonic stem cells have the remarkable ability to develop into any type of cell. On their way to become for example a liver or a heart cell, they must repeatedly decide between alternative developmental paths. How they make these decisions is largely unknown. An international team of biophysicists…

Imagine: you walk into a museum, see something that catches your eye and before you know it, you have an internship. This is what happened to history student Davey Verhoeven, who went on to work on the exhibition about the unique Japanese folding screen by Kawahara Keiga (approx. 1786 – approx. 1860)…

Prof.Dr. Herman van Vlijmen was appointed as Professor of Computational Drug Discovery at the Division of Medicinal Chemistry in Leiden on April 15th, 2008. He will give his Inaugural Lecture on May 18th, 2009.

How can we translate more fundamental discoveries into clinical solutions for patients? From that question, the Oncode Accelerator programme emerged. Professor of Molecular Physiology Mario van der Stelt has been one of the driving forces behind it since its inception. In an interview on the website…

Treatment with special stem cells seems to be a good option for suppressing the immune system in organ transplants. Researchers are trying to learn from processes that take place in the human body during pregnancy.

Key publications of the Quantitative Clinical Pharmacology group