A punishment that fits the crime is the cornerstone of the rechtsstaat or constitutional state. But opinions differ greatly on what constitutes a just and effective punishment. Research by Leiden University provides politicians, legislators, law enforcers and the public with new information and insights…

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.

Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…

On this page you will find a collection of presentations and videos of the Florence Nightingale Colloquia, seminars at the faculty and other event recordings hosted by the Data Science Research Programme.

A full overview of MacBio PhD Theses.

Key publications of the Predictive Pharmacology group.

A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…

The Kroese-Duijsters Symposia aim to provide researchers from different fields and different career stages to meet in an informal setting, to stimulate discussions and to start new collaborations. The Kroese-Duijsters Symposia started in 2022 and we are pleased to invite you to the 3rd Kroese-Duijsters…

Scientific Director of the Leiden Academic Centre for Drug Research (LACDR) Hubertus Irth: ‘We test substances and look for new concepts for treating disease.’

Health is a wonderful gift, both for humans and for society. If we are able to prevent both physical and mental illnesses, we can spare a lot of suffering and fight rising health costs. Social scientists and physicians in Leiden are working closely together to conduct research on the human mental, behavioural…

The elderly accept may minor discomforts like stiffer muscles and getting tired more quickly, but they do want to go to their children's birthdays independently. Preventive elderly care helps people with that. The goal is to let people grow old while maintaining their self-reliance and independence…

Physics and Engineering Approaches to Biomedicine and Pharmacology

We also conduct research to make meaningful contributions to society. For instance, by talking about our research, contributing to community projects or by inviting people to help us with our research. Scroll down and discover how Science and Society can mutually reinforce each other.

PhD defence

PhD defence

Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Publication on the excavations at Roman fort Matilo in Leiden

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Complex systems can be characterized as systems in which multiple components interact with each other, often in non-linear ways. The main goal of this research will be to investigate if and how the international tax system can be defined and modelled as a complex system. Approaching the international…

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

An experimental approach to organic palaeolithic technology

This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.

This research investigates everyday lives and workplace experiences of Iranian workers employed at textile industry, which was the second biggest industry after oil following the latter’s discovery in 1908.

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

This doctoral trajectory explores sound, its image and its role in relating humans and our technologies to the environment.

The LOFAR radio telescope produces petabytes of data every year. Radio Astronomers use complex multi-step pipelines to process this data and produce scientific images.

New perspectives from archaeology and ancient history

This PhD research sets out to unravel and explain the socio-structural and cultural impacts of oil-industrialization on the local Bakhtiari community in general and the industrial laborers it provided in specific.

Promotor: Prof.dr. T. Schmidt, Co-promotor: Dr. ir. S. J.T. van Noort

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

The Next444 project focuses on the future of interdisciplinary research at Leiden University.

Implementation of the new sound synthesis and analysis method in music composition.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

In order to realise high quality valorisation of scientific research, eLaw practices valorisation activities during all stages of its research, i.e., not only after finishing research, but also prior to and during research.

Over the last decades, the systematic investigation of urban settlements in Central-Tyrrhenian Italy led to the discovery of a growing number of contexts revealing both direct and indirect evidence of artisanal workshops. Such research commitment has yielded a vast amount of new data that greatly contribute…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Director: Dr. Fred Leemhuis

Excavations at Geleen-Janskamerveld 1990/1991

This is an Erasmus+ International Credit Mobility project of the Faculty of Sciences with one partner in Ukraine.

ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.