An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.

Drug development is a complex process in which many parties work together. Every day, the researchers at LACDR devote their energies to developing drugs that are new, better, more efficient and easier to produce. And thus to the millions of patients who know all too well why this research in Leiden…

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

Supervisor: Gerard van Westen

‘A challenging rollercoaster, but also a very bonding and insightful experience,’ that’s how the team of iGEM Leiden 2022 wraps up their participation in the iGEM contest. The contest for synthetic biology climaxed during the Grand Jamboree in Paris. The team ended up in the top 10 of over 360 teams…

KNAW has elected eighteen new members, including two professors at Leiden University and one who studied and obtained his PhD in Leiden. The New Academy members will be installed at a later date this year.

A CT scanner to treat eye cancer, energy-efficient software for the future and a test to identify male chick eggs. Three projects by researchers from Leiden University are to receive funding from research funder NWO’s Open Technology programme, to which the business sector also contributes.

PhD defence

Truth is stranger than fiction. In 1997 Juan Maldaceña discovered a remarkable dictionary that translates equation for equation the physics of black holes in string theory into the more conventional physics of quantum mechanics of interacting particles. The remarkable possibility exists that…

Dr. Doris M. Jacobs, Lead Scientist at Unilever R&D, Wageningen, The Netherlands.

The studies in this thesis are focused on the physical effects in the flat band materials. The results contain the discovery of strong enhancement of RKKY spin-spin interactions with specific geometric arrangement and dynamical generation of excitonic order parameter with high magnitude.

Since 2019, the Foundation for Austrian Studies organises an annual lecture in cooperation with the Institute for History.

This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.

Promotor: Prof.dr. G.P. van Wezel

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

Een samenwerking tussen het Leids Universitair Medische Centrum (LUMC), de Universiteit Leiden en Philips ontvangt financiering van wetenschapsfinancier NWO om MRI-scans te versnellen. Deze drie partijen vormen samen een van de 17 AI-labs die onder de naam ROBUST voor een periode van 10 jaar NWO-steun…

Op 4 oktober vindt op de Vrije Universiteit het symposium "Kronieken, 1400-1850" plaats. Dit symposium wordt georganiseerd ter ere van het verschijnen van de handelseditie van het proefschrift van Peter Bakker. Drie VU-historici belichten hun onderzoek naar dit onderwerp vanuit verschillende hoeken.…

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

Dendritic cells (DC) play a prominent role in the priming of CD8(+) T cells. Vaccination is a promising treatment to boost tumor-specific CD8(+) T cells which is crucially dependent on adequate delivery of the vaccine to DC.

How can you use robots and automatic recognition of microscopic images to test the effect of drugs exceptionally quickly?

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

Research on this theme addresses the systemic risks faced by European societies and affecting the quality of life of European citizens.

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

The Leiden Institute of Chemistry organises and participates in several programmes for high school students and teachers.

We are interested in understanding the mechanics of soft materials, of which biological materials are prominent examples.

The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.

Source: J Cheminform, Volume 7, Issue 1 (2015)

Microbial Sciences' contribution to the Bioactive Molecules research theme is to discover new bioactive molecules and enzymes and unravel their mechanisms of action, regulatory networks, and the (bio)synthetic pathways required for their production.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Due to the modern techniques of combinatorial chemistry and high-throughput screening, data on the biological activity of many millions of compounds is known. However, it is still very difficult to transfer this data into knowledge: if we know that compounds A and B bind to a certain protein with high…

The Biomedical Sciences Health specialisation aims to provide you with a theoretical background and academic competences in multidisciplinary research in Biomedical Sciences and in clinical practice in Medicine. Since the programme is partly taught in English and partly in Dutch, fluency in Dutch is…

Have you spotted the special voting bins on campus yet? Send us your suggestions for challenging, non-scientific questions and who knows? Your burning question might just be the next butt-kicker!

Mario van der Stelt has been appointed Professor of Molecular Physiology at the Leiden Institute of Chemistry with effect from 1 November 2017.

The discovery in 2001 of the importance of microRNAs turned the world of molecular biology upside down. The small particles of RNA also attracted the attention of university lecturer Erno Vreugdenhil. Vreugdenhil: ‘Within five to ten years the first microRNA-directed medicines will come onto the mar…

PhD defence

PhD defence

PhD defence

On Monday 15 February 2016 the annual Speckmann Prizes were granted at the Institute of Cultural Anthropology and Development Sociology. BA-studenten Laura Bakker, Kimberly Drijver and Martijn Kooijman were awarded for the best Fieldwork NL project; Rosi Aryal was honoured for having written the best…

PhD research recently completed by pharmacologist Margreke Brill shows that morbidly obese patients should be given a different dosage of the drugs Cefazolin and Midazolam. This could also apply to other drugs such as anti-cancer drugs as well as antibiotics and Margreke Brill is advocating a change…

In order to stop a whole range of diseases or disorders at their source, you would have to be able to switch certain genes on or off. Sebastian Pomplun wants to develop substances that can do this very precisely. For example, he wants to disrupt cancer processes and make cells produce an important missing…

The central research question focuses on identifying shifts in the urban social network in terms of private, semi-public and public space by means of mapping the spatial distributions of wells and cesspits in the town of Haarlem in the course of the pre-industrial period (1200-1800). Shifts may be indicative…

European product safety law is one of the focal points of internal market legislation.

The Cryogenics Department has a liquid helium production unit and an automatic liquid nitrogen filling plant.

The transition to new and renewable energy sources should be completed by 2050. Researchers in various disciplines at Leiden University are conducting unique research that will help us make this transition and reduce CO2 emissions.