Bacteria caught red-handed, deeply frozen just as they were about to cause Lyme’s disease. Ariane Briegel is wildly enthusiastic about the wonders she observes thanks to three elements: a freezing technique, a camera-equipped microscope, and AI. ‘It’s fascinating. Every single cell is different.’

Synthetic cells, also known as artificial cells or protocells, have wide ranging applications from drug delivery vectors to cell models. In biotechnology they can function as micro- or nanoreactors with possible applications in biocatalysis and photocatalysis. Phospholipids are by far the most commonly…

Eduard Fosch Villaronga, Assistant Professor at eLaw, co-organised together with Aurelia Tamò-Larrieux, Christoph Lutz, Anton Fedesov, and Anto Čartolovni the GoodBrother International Conference on Privacy-friendly and Trustworthy Technology for Society on 28 June 2022 in Zagreb, Croatia.

On Friday 12 March 2021, the (Dutch) website www.codevoorkinderrechten.nl was launched. This code for children’s rights has been created to help those involved in the development and design of digital services to develop these services with the interests of children in mind.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Promotor: Roeland M.H. Merks

List of Support Departments at LION and the Faculty of Science

Supervisor: P.J.J. Hooykaas

Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

It’s not something the police force wants to see, but it still occurs: racist and misogynist police conduct. Human rights specialist Dr Linda Louis has studied how technology could help police officers behave correctly and comply with the applicable legal norms.

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

This article illustrates how the term 'dual use' has become associated with a broader dichotomy between ‘legitimate’ and ‘illegitimate’ purposes.

Bike Labyrinth is international market leader in providing virtual reality exercising for elderly care.

The Schengen Agreement has resulted in systematic border controls between EU Member States largely ceasing to apply. Solutions for the associated security risks are often sought in information technology. Tim Dekkers investigated how such technology is applied in this context and will defend his PhD…

Promotores: Prof. Dr. Th.J.C. van Berkel, Prof. Dr. M. van Eck

Discovery of metastasis promoting candidate drug targets

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

On 9 October 2023, Carlotta Rigotti and Eduard Fosch-Villaronga participated in the BIAS webinar on citizen science and AI technologies, namely the first awareness-raising activity of the Horizon Europe BIAS project. They discussed online citizens’ engagement on tackling gender and intersectional biases…

Dr. Eduard Fosch-Villaronga, Marie Skłodowska-Curie Postdoctoral Researcher at eLaw, received a personal visiting researcher grant from the Research Council of Norway to spend five weeks visiting the University of Oslo.

The Conference on Computers, Privacy and Data Protection (CPDP) is an annual world-leading multidisciplinary conference that takes place in January in Brussels. This year, eLaw, the Centre for Law and Digital Technologies of Leiden University, participates in the CPDP conference as one of the event’s…

PhD candidate Karen van den Akker has written a children’s book to get young girls excited about technology. The picture book ‘Met mama naar Mars’ tells the story of Luna, who wants to travel to Mars.

The Green algae Chara as model system for intra and inter cellular transport processes.

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.

Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.

Can we develop new enzymes and cell factories to upgrade current enzyme cocktails towards complete degradation of biomass?

During the final event of the PRE-Class Rechtsgeleerdheid, secondary school pupils organised a mock trial on the impact of artificial intelligence (AI) on society. Together with the audience, they explored the possibilities and pitfalls of AI. ‘They all did a wonderful job.’

Three researchers from Leiden University have received awards in the Quantum Technology programme within the National Growth Fund, organised by NWO in collaboration with Quantum Delta NL. Read more about these three futuristic projects.

Promotor: B. van de Water

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Our researcher and PhD candidate Helena Ursic was interviewed with Druzina, one of the biggest weekly newspapers in Slovenia.

On Wednesday 12 December 2018, the department of Child Law, on the initiative of dr. Yannick van den Brink, dr. Stephanie Rap en prof. dr. Ton Liefaard), organized an expert meeting on ‘Equality, children’s rights and digital technologies’. The objective of the meeting was an in-depth exchange of ideas…

Cutting down global emissions of greenhouse gases to combat global warming won’t do the trick alone: we also need negative-emissions technology that can capture carbon dioxide directly out of the air. In the prestigious journal Global Environmental Change, PhD candidate Oscar Rueda and colleagues shed…

An overview of our infrastructure at the SPP division:

Psychologists Emma ter Mors, Christine Boomsma and other research partners will share results from their work on the crucial issue of societal support for delivering carbon capture, utilisation and storage (CCUS) in Europe. You're welcome to watch the free webinar.

There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…

Students from eLaw completed a successful work experience programme researching contact tracing apps at Privacy Company in The Hague.

Below are some examples of ACPA projects that have a meaningful impact on arts and society. This page will be refreshed every now and then, presenting projects that exhibit how artistic research can significantly contribute to the way we perceive, understand, and relate to the world and to other pe…

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

For some devout Muslims, going to the cinema or viewing certain images is provocative and problematic. Ahmad Nuril Huda investigated the development Santri (young, pious Muslims) have undergone in this field over the past ten years. The Cinematic Santri is the result of his PhD research.