Promotor: G.P. van Wezel, Co-promotor: D. Claessen

The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…

The topic of Historical Linguistics and Philology at LUCL is language change in its broadest sense.

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

This study presents an agent-based simulation model exploring the patterns of presence and absence of Late Pleistocene Neanderthals in western Europe.

In the Drug Research theme, we primarily work with rodents. Rodents, such as mice, are one of the most common laboratory animals. These small mammals are easily housed and exhibit a rapid rate of reproduction.

What is the role of neuronal emotional reactivity in the intergenerational transmission of abuse?

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

Are you interested in taking up an extra challenge during your master’s programme? Have you thought about developing your personal leadership style?

The origins of Surinamese rice, a digital twin of the Earth and a large big-data project in the Chilean sky: three Leiden scientists receive an ENW-KLEIN grant for innovative, fundamental research.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

VVI Research Meeting 2023-2024

Radio telescope LOFAR maps the sky. It produces incredibly detailed images of the universe - and vast amounts of data. Huub Röttgering, director of the Leiden Observatory, talks about the challenges of working with those enormous datasets.

Research in the POD-group addresses all features of random phenomena – modelling, structuring, analysis, control, optimisation – and covers both fundamental and applied aspects.

In 2022, many of our staff and students won fantastic prizes and were awarded important research grants.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…

What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Promotores: A.H. Meijer, H.P. Spaink

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?

The Great Rift Valley in Africa is a real treasure trove for discovering early human fossils. The fossils found in this part of Africa have determined our view of human evolution. But was the Great Rift Valley really the place where evolution took place or just a place where fossils are well preserved…

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Is it possible to synthesize industrially relevant compounds in a sustainable manner through the use of light-capturing cyanobacteria?

This dissertation provides a description of Konso, a Cushitic language spoken by about 250,000 speakers in the South-West Ethiopia.

How did toxin genes evolve from harmless physiological genes?

The Board of Examiners consists of scientific staff members of the IBL, Naturalis Biodiversity Center and CML, who teach in the biology programmes. They are appointed by the Board of the Faculty of Science and act independently from the research institutes. The responsibilities of the board include…

The master's specialisation Applied Mathematics at Leiden University focuses on both computational and fundamental aspects of analysis and probability. It’s also an ideal basis for a PhD degree. Applied Mathematics is an excellent choice if you have the aspiration to pursue a PhD degree

Leiden University offers you several services related to career orientation and job application skills.

When you apply for admission, you’ll be asked to submit several documents.

Promotor: Prof.dr. M.K. Richardson, Co-Promotor: F. Witte

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Does a moving hybrid zone leave a genomic footprint?

This study offers a comprehensive but balanced grammatical analysis of Ik (Icetod), Northeast Uganda’s last thriving Kuliak language.

Atopic dermatitis (AD) is a common inflammatory skin disorder characterised by various epidermal alterations. Filaggrin (FLG) mutations are a major predisposing factor for AD and much research has been focused on the FLG protein.

Reconstructing language history and prehistory in the context of the Indo-European language family.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

How does FoxP1 affect auditory perception on a behavioural and genomic level?

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We work on clinical problems that require further mechanistic understanding and strive for ultimate benefit to patients.

The article investigates the origins of Indo-European languages in Asia by 65 coupling ancient genomics to archaeology and linguistics.

Control of infectious diseases poses continuous challenges for human health.

Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)