Brand-new professor Gerard van Westen works at the intersection of artificial intelligence and drug development. For the new chair in Artificial Intelligence and Medicinal Chemistry, he uses computer models to make drug development more efficient. Our ultimate goal is a virtual human which allows you…

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

In neonates and infants, body size, enzyme pathways, and expression and function of receptors and (target) proteins are still developing.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: A. Kros

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

An overview of the research at the Biologics Formulation group

Legal frameworks are often a pitfall when it comes to citizens’ initiatives. Esmee Driessen, a guest lecturer at the Department of Constitutional and Administrative Law and an expert in citizen participation, conducted research on the support and facilitation of citizens' initiatives. In a Dutch journal…

The focus of the Antiviral Pharmacology group led by Anne-Grete Märtson is optimizing antiviral therapy for different viral infections by conducting clinical trials and using innovative computational and dynamic laboratory methodologies.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We are moreover strongly involved in the Master specialisation of Pharmacy at Leiden University. We work on clinical problems that require further mechanistic understanding and…

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We work on clinical problems that require further mechanistic understanding and strive for ultimate benefit to patients.

On April 19, Pax Initiative, a youth led NGO, held its first ever event at the Museon in the Hague. The event, “International Court of Justice Idealab: The Future of the ICJ” was a productive and inspiring discussion among students and young professionals on how the Court can reach the 16th Sustainable…

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Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

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We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.

Art of Captivity / Arte del Cautiverio tells a compelling story about Central America's drug war through a series of rich photographs. The book, which is entirely bilingual in English and Spanish, focuses on Guatemala, which has become the primary point of transit for cocaine produced in the Andes and…

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Throughout the year, the organisation 'Voedsel Anders' organizes an events series that showcase various local food initiatives in Dutch cities.

One of the holy grails of drug research is to be able to assess the safety of chemicals and pharmaceuticals without using laboratory animals. Researchers from Leiden University, among others, now receive a grant from the National Science Agenda to pursue that goal.

The Third International Conference on Environmental Peacebuilding is set to take place between 19 and 21 June at the Wijnhaven building in The Hague. During the conference, over 400 participants from across the globe will come together to discuss the relationship between the environment and armed co…

In the Phenomix Medical Delta Field Lab, which was officially opened on Thursday 9 July, scientists, healthcare institutions and businesses work together to develop innovative applications in the field of metabolomics. This research field makes it possible to determine which drugs will be effective…

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

'Mariana Gkliati delivered a presentation entitled: 'Accountability of the Europepan Border and Coast Guard Agency: The Litigation Route' at the Refugee Law Initiative's 2nd Annual Conference in London, on Monday 5 June

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…

An important hormone excreting gland in the human body is the pituitary

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

The master’s specialisation BioTherapeutics at Leiden University is a two-year programme which trains students in research in specific drug delivery techniques. The programme also examines the development of new therapeutic approaches to treat immune-based disorders, such as atherosclerosis, metabolic…

Mariana Gkliati presented on Tuesday 2 June at the 4rth Annual Conference of the Refugee Law Initiative organised at the University of London. The title of the conference was Rethinking the ‘Regional’ in Refugee Law and Policy.

Leiden University has made available Kiem (seed) grants of €10,000 - an initiative for developing new interdisciplinary, interfaculty research partnerships and encounters. Helen Pluut is part of a Kiem team, one that brings together researchers from Leiden Law School, LUMC, FSW and ICLON (and Young…

About nine million people worldwide contract tuberculosis each year. Research into new treatment for this disease has received fresh stimulus with more efficient techniques and a new understanding of how the tuberculosis bacteria works.

The two-years master’s specialisation System Biomedicine and Pharmacology at Leiden university focuses on predicting drug response with computational modelling, developing individualised therapies, and developing innovative analytical tools for personalised health strategies.

Division contact information & address

Leiden chemists have proposed a new model for enzymatic reactions, in which the flexibility of the substrate is much more important than previously thought. Their results are paradigm-shifting and could have major implications for drug research and enzyme engineering. Publication in Angewandte Chemi…

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Knowledge is everywhere at Leiden University. It is also accessible for those who do not study or work at the University.

Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…

The Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug action that have been used in pharmaceutical and/or academic research. This publically available open-access resource will make it easier for researchers…

Students are ever more cautious to express their view on controversial debates. The new student-led D&I initiative at the Faculty of Humanities, COOP, is ready to step in. They organise sessions to guide students on speaking up and respecting the views of others at university.