PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

List of Support Departments at LION and the Faculty of Science

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

To be able to identify, slow down and reverse functional deterioration in the elderly to give them more years of good health.

The HOPES study is one of the largest investigations of this kind to date! By studying existing brain scans and data collected form over 4,000 14-25 year olds, the project team hopes to identify specific changes in the brain that make young people vulnerable to suicidal thoughts and behaviours.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Research projects

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Within this project, PeptoMiktoStars were realized through an orthogonal protecting group strategy and should be investigated further regarding their potential as drug delivery systems in the field of drug delivery to inflamed areas in cancer, bacterial infections or autoimmune diseases.

In the Drug Research theme, we primarily work with rodents. Rodents, such as mice, are one of the most common laboratory animals. These small mammals are easily housed and exhibit a rapid rate of reproduction.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

The Supramolecular & Biomaterials Chemistry group comprises the PIs Alexander Kros, Roxanne Kieltyka, Gregory Schneider and Sander Wezenberg, and is active in the field of self-assembly of amphiphilic peptides and applying them in supramolecular chemistry.

Lecture

The group Statistical Science is responsible for research and teaching in statistics and data science.

Two excellent young chemists, Jeroen Codée and Sander van Kasteren, have received an ECHO grant for €260,000 from the Netherlands Organisation for Scientific Research (NWO). This funding will allow them to begin their research projects.

The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…

The AiChemist project (https://aichemist.eu) coordinated by Helmholtz Munich is an Innovative Doctoral Training Network funded through the Marie Skłodowska-Curie Actions (MSCA-DN) within the EU Horizon Research Framework, to the sum of €3 million. It brings together leading experts in AI, chemoinformatics…

LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Bioactive Molecules is one of the four research themes of the Institute of Biology Leiden.

Studying linguistics at the Leiden University Centre of Linguistics (LUCL) is a challenging but rewarding experience. There are few places in the world where such a broad range of languages are studied from so many different perspectives.

What is your favourite thing about Leiden University?

Lecture

For her bachelor’s thesis, Molecular Science and Technology student Madouc Bergers synthesized her own molecule that can inhibit the breakdown of sugars. Although most students do not even manage to make one building block, Madouc made three. Partly because of this, she has been nominated for the Science…

Lecture

This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the Taras Shevchenko National University of Kyiv.

The Leiden Academic Centre for Drug Research (LACDR) is responsible for the research and education in Bio-Pharmaceutical Sciences carried out at Leiden University.

Leiden chemists have developed a new technique with which they can determine the role of kinases – a group of proteins – in a living cell. This technique makes it easier to find new drug targets for diseases such as cancer and rheumatoid arthritis. The team published the findings in the journal Nature…

Van 21 augustus tot en met 8 september zijn de workshops en cursus van de jaarlijkse Summer School on the History of the Book van het Allard Pierson en de vakgroep Boekwetenschap. Drie weken lang is er elke werkdag een cursus, workshop of lezing over thema’s die te maken hebben met de geschiedenis van…

The ability to collect and interpret huge quantities of data has become indispensable to society and academia. Leiden University is a knowledge and expertise centre for data science that places the emphasis on interdisciplinary collaboration and innovation.

Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics

Which immune mechanisms are involved in host defense against Staphylococcal infection?

An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.

Drug development is a complex process in which many parties work together. Every day, the researchers at LACDR devote their energies to developing drugs that are new, better, more efficient and easier to produce. And thus to the millions of patients who know all too well why this research in Leiden…