1,485 search results for “brain models” in the Public website
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When data compression and statistics disagree: two frequentist challenges for the minimum description length principle
Promotor: P.D. Grünwald
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Structural Health Monitoring Meets Data Mining
Promotor: Prof.dr. J.N. Kok, Co-promotor: Dr. A.J. Knobbe
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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Lipid mediated colloidal interactions
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.
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Neural correlates of vocal learning in songbirds and humans: cross-species fMRI studies into individual differences
Vocal learning is a trait shared by songbirds and humans. It is also a trait that is restricted by the brain rather than by a species' vocal apparatus. In this dissertation, functional MRI is employed in both species in order to explore potential common neural mechanisms underlying the ability to develop…
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Children's stories as a window to investigate empathy
Researcher Max van Duijn and PhD student Bram van Dijk apply language models to stories told by children to investigate empathy. For this research, they received the Best Paper Award at the Computational Natural Language Learning Conference in Singapore.
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Research
The Institute of Psychology is responsible for innovative and interdisciplinary research and education within psychology and related disciplines. It focuses primarily on four broad areas: Health and Wellbeing; Development and Learning; Socio-Cognitive-Affective Decision-making and Advanced Behavioural…
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LIBC Meetings & Events
The LIBC organizes a yearly LIBC Public Scientific Day, Colloquia, Sylvius Lectures and so on.
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Contact
General contact information.
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The importance of relating to others: why we only learn to understand other people after the age of four
When we are around four years old we suddenly start to understand that other people think and that their view of the world is often different from our own. Researchers in Leiden and Leipzig have explored how that works. Publication in Nature Communications on 21 March.
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Uniform infinite and Gibbs causal triangulations
Promotor: Richard D. Gill
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24-hour rhythms in drug exposure and effect
Although rarely considered by the pharmaceutical industry or clinicians, 24-hour rhythms in physiology are a factor of potential influence on the pharmacokinetics and pharmacodynamics of drugs.
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Born to be shy?
An international mega-analysis on the neurobiological link between inhibited temperament and social anxiety disorder
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Cognitive enhancement: Toward the integration of theory and practice
Cognitive enhancement reflects the use of any (legitimate) means such as for example food supplements to reach one’s personal best.
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Topic: Movement and mental functions
Our ability to learn and control movements is essential for engaging in goal-directed behaviour. From buttoning your shirt and driving a car, to cooking dinner and brushing your teeth -- our actions in daily life rely on this ability.
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Spinoza Prize for ‘puberty professor’ Eveline Crone
Eveline Crone, Professor of Neurocognitive Developmental Psychology, has been awarded the NWO Spinoza Prize for her high-profile research on adolescent development. NWO announced the award on 16 June. What will Crone do with the award of 2.5 million euros?
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Research
The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.
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Supramolecular & Biomaterials Chemistry
The Supramolecular & Biomaterials Chemistry group comprises the PIs Alexander Kros, Roxanne Kieltyka, Gregory Schneider and Sander Wezenberg, and is active in the field of self-assembly of amphiphilic peptides and applying them in supramolecular chemistry.
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HOPES Study
The HOPES study is one of the largest investigations of this kind to date! By studying existing brain scans and data collected form over 4,000 14-25 year olds, the project team hopes to identify specific changes in the brain that make young people vulnerable to suicidal thoughts and behaviours.
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Self-regulation in boys with ODD/CD
Understanding individual differences in self-regulation in boys with ODD/CD on the level of brain, cognition and behavior
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Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474, SCIENCE, 2017
The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…
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Health, Medical and Neuropsychology
The unit Health, Medical and Neuropsychology offers eduction and conducts research on related fields of Health, Medical and Neuropsychology.
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Distance-based analysis of dynamical systems and time series by optimal transport
Promotor: S.M. Verduyn Lunel
- Martina Huber Lab - EPR Group
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Education
The group is involved in training in areas of diagnostic skills, treatment/prevention/intervention, neuropsychological assessment, behavioral observations, clinical interviewing, knowledge of intellectual disability, autism, ADHD, psychosis and aggression.
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Lab facilities Cognitive Psychology
Reactions and reaction times in cognitive tasks.
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Nanomedicine to Visualize and Treat Inflammation after Stroke (NAVISTROKE)
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Experimental Linguistics
How do we process language and speech? How do we integrate information at different levels – intonation, sentence structure, meaning, tone, words, sounds - and how does information at one level interact with information at another level?
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High-field neuroimaging of computational processes that drive cognitive control.
How do humans control their thoughts and actions, and what can high-field brain scanning reveal about the underlying processes?
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Gut Feelings: Vagal Stimulation Reduces Emotional Biases
Stimulating the vagus nerve, which provides a direct link between the gut and brain, makes people pay less attention to sad facial expressions. This research study by psychologists Katerina Johnson and Laura Steenbergen is published in the journal Neuroscience, and made it to the cover.
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Outreach
We recognize the importance of communicating about our scientic work to the general public and we enjoy doing so. Recently, we received funding from the Pilot fund Science communication by scientists: Appreciated! (with members of Change Leiden) to engage children and adolescents in science communication…
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About the programme
The programme of the master specialisation Learning Problems and Impairments studies common learning problems such as dyslexia, hyperlexia and dyscalculia, as well as learning disabilities caused by AHDH, ADD or speech and language disorders. Much attention is also devoted to the relation between brain…
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Seminars
LCN2 organizes seminars on the last Friday of each month.
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Jan Willem Erisman on the nitrogen crisis: 'The measurement model works, but the minister is setting reduction targets that are too high'
Opponents of drastic nitrogen measures argue that the nitrogen calculation model is not reliable enough. Nitrogen professor Jan Willem Erisman: 'It is now much more important to discuss the choices we make on the basis of the outcome. The differences are much bigger than the uncertainties in the mod…
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Publications
Here, you can browse the publications of the Navigation Lab Leiden:
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De Lange appointed Professor of Predictive pharmacology
As of 1 March 2018, Elizabeth (Liesbeth) de Lange has been appointed as Professor of Predictive pharmacology at the Leiden Academic Centre for Drug Research (LACDR). She is head of the research group Predictive Pharmacology and mainly aims at developing mathematical models that can predict the effect…
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3D modeling and RNA-based therapeutics for Dutch-type Cerebral amyloid angiopathy
PhD defence
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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ERC Consolidator Grant for Eveline Crone
Eveline Crone surmises that adolescence also has a positive effect on social development. She believes, for example, that it is in adolescence that young people learn the skills of cooperation, sharing and helpfulness. She will be researching this hypothesis in the coming period with an ERC Consolidator…
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LED3 Drug Discovery Case Studies
To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Pharmacometabolomics; prediction of system-wide multi-biomarker drug response
The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.
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Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
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Yingjie Fan
Science
y.fan@liacs.leidenuniv.nl | +31 71 527 4799
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Tomer Fishman
Science
t.fishman@cml.leidenuniv.nl | +31 71 527 2727
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Garnet Akeyr
Science
g.j.akeyr@math.leidenuniv.nl | +31 71 527 4845
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Bas ter Braak
Science
s.j.ter.braak@lacdr.leidenuniv.nl | +31 71 527 2727
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Marije Niemeijer
Science
m.c.niemeijer@lacdr.leidenuniv.nl | +31 71 527 6105