Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

This article illustrates how the term 'dual use' has become associated with a broader dichotomy between ‘legitimate’ and ‘illegitimate’ purposes.

Dr. Eduard Fosch-Villaronga, Marie Skłodowska-Curie Postdoctoral Researcher at eLaw, received a personal visiting researcher grant from the Research Council of Norway to spend five weeks visiting the University of Oslo.

The Conference on Computers, Privacy and Data Protection (CPDP) is an annual world-leading multidisciplinary conference that takes place in January in Brussels. This year, eLaw, the Centre for Law and Digital Technologies of Leiden University, participates in the CPDP conference as one of the event’s…

The Green algae Chara as model system for intra and inter cellular transport processes.

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.

Can we develop new enzymes and cell factories to upgrade current enzyme cocktails towards complete degradation of biomass?

Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Promotor: B. van de Water

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

An overview of our infrastructure at the SPP division:

Three researchers from Leiden University have received awards in the Quantum Technology programme within the National Growth Fund, organised by NWO in collaboration with Quantum Delta NL. Read more about these three futuristic projects.

Our researcher and PhD candidate Helena Ursic was interviewed with Druzina, one of the biggest weekly newspapers in Slovenia.

On Wednesday 12 December 2018, the department of Child Law, on the initiative of dr. Yannick van den Brink, dr. Stephanie Rap en prof. dr. Ton Liefaard), organized an expert meeting on ‘Equality, children’s rights and digital technologies’. The objective of the meeting was an in-depth exchange of ideas…

There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

For some devout Muslims, going to the cinema or viewing certain images is provocative and problematic. Ahmad Nuril Huda investigated the development Santri (young, pious Muslims) have undergone in this field over the past ten years. The Cinematic Santri is the result of his PhD research.

Researchers at Leiden University have mapped genes that cause breast cancer cells to migrate. The Leiden toxicologists Professor Bob van de Water, Dr Wies van Roosmalen, Dr Sylvia E. Le Dévédec and colleagues studied 1500 individual genes. They found eight, including the SRPK1 gene, that regulate the…

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

Is there a sufficiently large market for drug screening and testing in Zebrafish larvae using membrane fusion?

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Promotores: J. Jonkers, K.E. de Visser

Vaccination via the skin or the mucosae

Ecotox is located in an ambitious surrounding at the Leiden University. It is an initiative of both institutes Institute of Environmental Sciences (CML) and Institute of Biology Leiden (IBL).

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Lars Jeuken, Anne Wentink, Anjali Pandit, René Olsthoorn and Alia Matysik.

The imaging group focuses on bio-imaging, image analysis and visualization.

The LUMC Flow Cytometry Core Facility accommodates all research and diagnostic flow cytometry equipment of the LUMC.

We investigate reaction systems, a novel computational model gleaned from the biochemical reactions taking place in living cells and information processing in nature.

How can the transport of molecules in living cells help to target medicines at exactly the right place?

How do plant defense genes get activated?

How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?

In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.

The Leiden Academic Centre for Drug Research (LACDR) is a centre of excellence for multidisciplinary research on drug discovery and development.

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?