Sixteen researchers at Leiden University are to receive a Veni grant from the Netherlands Organisation for Scientific Research (NWO). These awards offer promising young researchers the opportunity to further develop their own ideas over a period of three years.

The Joan van der Waals colloquium is an ongoing bi-weekly lecture series.

Festival

PhD defence

Genes predict whether you have a propensity for an illness but environmental factors often have the last word: nutrition, air pollution, lifestyle, stress. The exposome as both culprit and chance. Large-scale research is being carried out into this at Leiden. Thomas Hankemeier, Professor of Analytical…

In prehistoric times there was a huge wave of migration, from the steppes in Russia and Ukraine to West Europe. The newcomers’ genes began to dominate. Archaeology research in Leiden into burial mounds in the Veluwe and Utrechtse Heuvelrug areas of the Netherlands yielded this spectacular conclusion.…

For their research many neuropsychologists use the brain scanners at the LUMC. At the start of the pandemic, the rules for visiting the hospital became stricter and a large amount of psychology research looked as though it would fall through. Thanks to good protocols the researchers can now pick up…

Lecture

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process.

Patients with the same illness often receive the same treatment, even if the cause of the illness is different for each person. This represents a new step towards ultimately being able to offer every patient more personalised treatment.

Eleven talented Leiden researchers with several years of research experience have been awarded a Vidi subsidy to set up or expand their own line of research.

The team of Alireza Mashaghi at the Leiden Academic Centre for Drug Research has found a way to determine and classify the shape of proteins. Their new theory defines the topology of proteins as a simple and precise barcode that allows the identification of all types of folds. ‘This barcode enables…

The discovery in 2001 of the importance of microRNAs turned the world of molecular biology upside down. The small particles of RNA also attracted the attention of university lecturer Erno Vreugdenhil. Vreugdenhil: ‘Within five to ten years the first microRNA-directed medicines will come onto the mar…

Leiden chemists have developed a new technique with which they can determine the role of kinases – a group of proteins – in a living cell. This technique makes it easier to find new drug targets for diseases such as cancer and rheumatoid arthritis. The team published the findings in the journal Nature…

Autism, Alzheimer’s, and bipolar disorder: can the development of these mental health conditions be influenced by the ketogenic diet? Increasingly, research suggests it might. 'For those it helps, it can be life-changing,' says neuroscientist Eline Dekeyster.

A group of single-celled organisms organises its DNA in a similar way to higher organisms such as plants, animals, and fungi. However, the way packaged DNA is read out differs between the two related groups, Bram Henneman discovered. PhD defence on 5 December.

Five researchers from Leiden University have been awarded a Starting Grant by the European Research Council (ERC). This grant of on average 1.5m euros enables researchers who show potential to start their own project, lead a research team and implement their best ideas.

The Institute of Biology Leiden has a new visiting professor as of the first of May. Bioinformatician Marnix Medema holds the Van der Klaauw chair for a year and looks forward to scientific collaborations and to boost the bioinformatics education.

It has only recently been discovered that single-celled organisms (bacteria and archaea) also have histones—proteins that structure DNA. Now, Leiden PhD candidate Samuel Schwab has found that the histones in these organisms are much more diverse than previously thought. Schwab and his colleagues describe…

Plants can’t run away from enemies. Still, it would like to keep life-threatening herbivores at a distance. This can be done with odours. Klaas Vrieling of the Institute of Biology Leiden found out with his team how plants change odour production to keep the munchers at a distance.

One of them turned out to be two thousand years old. And older giant barrel sponges appear to have a faster rate of cell division, unlike us. They produce antibiotics and much, much more. Lina Bayona Maldonado studied how the differences in such factors as age or oceanic depth affect the production…

Effectively treating a severe case of pneumonia is often challenging. Identifying the pathogen behind it can be difficult. PhD candidate Ilona den Hartog tried something new: ‘We searched for answers in substances our own body produces.’ PhD defence on 17 September.

Over hundreds of thousands of years, our region witnessed the comings and goings of various types of hominin. This depended on the temperature as ice ages alternated with warmer periods. In ‘De eerste mensen in de Lage Landen’ (‘The First Humans in the Low Countries’) Leiden archaeologists Yannick Raczynski-Henk…

Exclusion elicits the same response in children as in adolescents and adults. That is what psychologist Mara van der Meulen found when she studied brain activity in primary schoolchildren. ‘What is new for us is that it is the same in childhood as later in life.’ Doctoral defence on 10 December.

A group of biology students are working on a solution to the world’s plastics problem by getting bacteria to make biodegradable plastic.

‘Children’s rights are somewhat of a poor relation’, says Professor of Law and Health Mirjam Sombroek-van Doorm. In her inaugural lecture, she will emphasise how more attention needs to be paid to children’s rights in current thinking on law and health.

Fighting against cancer, antibiotic resistance and disposable plastics: Ahmed Ali, Fredj Ben Bdira, and Valerio Barbarossa receive a LUF grant for their innovative and socially relevant research. These grants for academic talent are often an important step towards grants by NWO and other grant insti…

Seven Leiden researchers have been awarded a prestigious Vici grant by the Netherlands Organisation for Scientific Research (NWO).

Researchers from the Plant Ecology and Phytochemistry group at the Institute of Biology Leiden (IBL) received an STW (Stichting Technologische Wetenschappen) grant for applied studies in plant herbivore resistance with potential for a novel resistance test.

From artificial intelligence to letters from the Dutch East Indies and from breast-cancer gene BRCA-1 to the collaboration between government and opposition: nine researchers from Leiden University have been awarded a Vidi grant for their research.

Several consortia in which Leiden University is involved have been awarded Dutch Research Agenda funding. Leiden is the coordinator of five of these consortia. These five consortia will receive grants worth a total of almost 24 million euros. They relate to interdisciplinary projects that will bring…

Biological chemist Nathaniel Martin and his team received an NWO grant to examine how blocking a specific enzyme in our body, NNMT, could be helpful in the treatment of some cancers. Trials with mice have been promising, and together with the Netherlands Cancer Institute, Martin wants to take the next…

Human measures to protect lions have an impact on the genetic health of populations. Leiden and Kenyan scientists discovered this by analysing the DNA of 171 Kenyan lions. ‘By fencing reserves, for example, the chance of inbreeding increases.’ With the knowledge and tools from the research, management…

Some people are more sensitive to depression than others. But why is that the case? Clinical psychologist Niki Antypa studied how vulnerability to depression is influenced by cognition. She also found a first careful indication that a treatment with omega-3 fatty acids might provide a solution.

Not experiments and lab coats, but computers and artificial intelligence: this year's Nobel Prize in Chemistry went to the inventors of the groundbreaking AI model, AlphaFold. This programme accurately predicts protein structures based on their genetic code—a crucial step in understanding biological…

Studying how single DNA molecules behave helps us to better understand genetic disorders and design better drugs. Until now however, examining DNA molecules one-by-one was a slow process. Biophysicists from Delft University of Technology and Leiden University developed a technique that speeds up screening…

The use of the pill, in combination with genetic factors, can influence experimental psychological research in women. More research is needed into the influence of the pill on mood disorders, concludes psychologist Daniëlle Hamstra. PhD defence on 30 September.

Macrophages – the front line of our immune system – protect us from infections. But in the case of the tuberculosis bacteria, this often goes wrong. The group of Annemarie Meijer from the Leiden Institute of Biology has now discovered that macrophages in zebrafish are better able to eliminate tuberculosis…

16 April was a special day at the Faculty of Science. In honour of the collaborations with the Chinese partner university, it was declared Xi’an Jiaotong University Day.

Leiden has scored highly with the recent Vici awards. Of the 31 Vici winners announced by NWO, 4 are researchers in Leiden. The winners are: Professor of Family and Child Studies Marian Bakermans-Kranenburg, information scientist Peter Grünwald, astronomer Linnartz and Professor of Buddhism Jonathan…

Early diagnosis, new treatments, and personalised care: all of these are possible if we can better unlock the wealth of information hidden in health data. Unfortunately, this data is often poorly organised, difficult to access, and not interoperable. The new international Leiden Institute for FAIR and…

How do animals choose their partners? The answer is simple: it’s all about quality. While humans tend to wear clothes that happen to be in fashion, animals do nothing without a reason. Behind beautiful plumage or a deafening roar is only one message: I am in great shape. The evolutionary courtship displays…

During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.

PhD defence

PhD defence

Lecture

PhD defence

PhD defence

PhD defence

Lecture