Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

Promotor: Prof.dr. E.F.A. Deprettere, Co-promoter: Todor P. Stefanov

TRANSVAC is a collaborative infrastructure project funded by the European Commission (EC), initially under the 7th Framework Programme (FP7) and currently under Horizon 2020. The project is a joint effort of leading European groups working in the field of vaccine development, and is coordinated by…

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Embedding ethical legal and societal aspects for responsible military AI.

M. Danhof, Co-promotor: O.E. Della Pasqua

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

Can the offering of host community compensation help to prevent or solve siting controversies, and if so, why and under which conditions?

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

This subproject of 'From Homo Economicus to Political Animal' analyzes Greek economic thinking in late 5th- and 4th-century philosophical circles.

Using object assemblages to reconstruct activities, modes of deposition and abandonment at the Late Bronze Age dunnu of Tell Sabi Abyad, Syria.

Jus post bellum, the body of laws and norms governing the transition from armed conflict to peace, has emerged as a crucial issue for international law scholars, governments, and all concerned with building a just and sustainable peace. The Jus Post Bellum Project, funded by the NWO and hosted by the…

In this article, the authors summarise the literature on the effects of multilevel governance on governments’ policy responses to Covid-19.

Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…

The refereeing process is anonymous. It is important, therefore, that all submissions conform to the above guidelines. The referees’ comments will, at the Editor’s discretion, be passed on to the corresponding author.

What should the EU do to support Ukraine, Belarus and Moldova? How can the European Union adapt its policies towards these countries in a very difficult and challenging geopolitical context?

We aim to create an innovative e-learning and virtual reality training that helps healthcare providers to optimize placebo effects and minimizes nocebo effects via their communication.

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.

The Netherlands Ministry of Defense and Ministry of Security and Justice have requested the Centre for Terrorism and Counterterrorism to complete a research project on cyber governance from a policy perspective. The results of this project will contribute to the deliverables of the fourth International…

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

Relevant safety issues are associated with hazardous materials transportation, especially when transport routes cross populated areas. This article for the Journal of Loss Prevention in the Process of Industries analyses a 2015 accident with a freight train in Tilburg, comparing it to the Viareggio…

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

The members of LUXs develop and validate new methods and algorithms for analysing data, and apply these in a wide range of problems. Their research ranges from multidisciplinary applications to proving mathematical theorems.

On the 13th of November, Hanna Fricke successfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Hanna on this achievement.

The ‘Leer te Durven!’ program (Learn to Dare) is a preventive training program for children with mild anxiety symptoms (Simon & Bögels, 2014). The program has been developed for children between the ages of 8 and 12 who feel or behave anxiously, avoid situations, are afraid of doing things wrong, appear…

Playing a musical instrument is generally considered to be a complex human behaviour involving the integration and coordination of a broad range of human functions such as perception, imagination, memory, information processing, emotion, communication, and dexterity.

Promotor: J.M. van den Broek Co-promotor: M.C. de Vries

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh

Technological advances, such as virtual reality, augmented reality and online assessment platforms are rapidly improving. These tools could potentially contribute to neuropsychological assessment that is more efficient and of higher quality.

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

This editorial to RHCPP discusses how COVID-19 can be seen as a 'creeping crisis' according to the authors of its lead article (Boin et al, 2020) and how resilience may depend on the real heroes behind the scenes of response to disaster and adversity.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

From where litter ends up to which languages are spoken in Leiden and The Hague: over 50 interesting, surprising, complex and entertaining questions were sent in for the Citizen Science project to mark our 444th anniversary. Not one but two Citizen Science projects will be starting this year in Leiden…

In this paper, Andrea Malaya M. Ragragio and Myfel D. Paluga recast new light on the historical tattooing of the “Pintados,” or the the name by which the inhabitants of the Visayas Islands (in the central Philippines) were called by Spanish documenters in the sixteenth century. This is one of their…

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Atopic dermatitis (AD) is a common inflammatory skin disorder characterised by various epidermal alterations. Filaggrin (FLG) mutations are a major predisposing factor for AD and much research has been focused on the FLG protein.

On 23 October 2019, Yoram Stein defended his thesis 'Spinoza's Theory of Religion: The Importance of Religion in Spinoza's Thought and Its Implications for State and Society'. The doctoral research was supervised by Prof. P.B. Cliteur and Prof. A.A.M. Kinneging.

Behrouz Karoubi defended his thesis on 15 June 2016

The RISIS project aims at creating a distributed research infrastructure to support and advance science and innovation studies. This will give the field a strong scientific push forward, and at the same time, provide a radically improved evidence base for research and innovation policies, for research…

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

The master's specialisation Occupational Health Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.

This summer school will explore the concept of socioeconomic diplomacy in the context of global empire building (16th-19th centuries).

The IEG specialisation prepares you with knowledge and understanding of the key concepts and theories of management, decision-making processes and implementation in EU and international institutions.

Are you looking for a research project? We have projects available for motivated 6–9-month internship students with particular interest in organic/polymer synthesis, formulation development, gene delivery, protein delivery, and the preliminairy in vitro screening of drug delivery platforms. Students…

Open access, online talks on African Sign Language Studies, in International sign and English