Daniel Peat will represent the ISDS Academic Forum, a group of over 150 academics whose research focusses on investor-state dispute settlement (ISDS), at forthcoming discussions on the reform of the ISDS system taking place in New York.

On Thursday 24 May 2018, Tanja Masson-Zwaan of Leiden University’s International Institute of Air and Space Law and Prof Mahulena Hofmann of the University of Luxembourg had the honour of addressing the King and Queen of the Netherlands and the Grand-Duc and Grand-Duchess of Luxembourg during the State…

PhD defence

PhD defence

PhD defence

Hungary belongs to the EU, but democracy is being seriously and systematically threatened there. Does the rest of the EU have the means and the political will to deal with member states that are out of step? Antoaneta Dimitrova, professor of 'Comparative Governance' at the Institute of Security and…

Host-Microbe Interactions is one of the four research themes of the Institute of Biology Leiden.

What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?

PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

The rapid advances in imaging technology enable to see inside the body with ever increasing detail.

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.

The Microscopy Unit houses, maintains and coordinates most of the microscopy equipment of the IBL. The available equipment ranges from conventional light and fluorescence microscopes, to confocal laser scanning and electron microscopes. In addition, infrastructure is available for histology, including…

The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Key publications of the Aging and Immunity group

Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?

The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

On Tuesday 22 January 2019, Beryl ter Haar participated in a comparative law lecture featuring labour law cases of the constitutional court of South Africa at the Kutafin State Law University Moscow, Russia. Topics discussed included short term employment contracts, the right to strike and the right…

Carola Schoor, programme manager for Public Affairs at the Centre for Professional Learning (CPL), reflects on Politico on the State of the European Union speech by Commission President Ursula von der Leyen from a political strategy and messaging perspective.

Dr Brian McGarry, Assistant Professor of Public International Law at the Grotius Centre for International Legal Studies, addressed the International Tribunal for the Law of the Sea in the world's first advisory proceedings concerning climate change. His advocacy for the Commission of Small Island States…

Tracing the residues of Neolithic activities through the study of stone artefacts

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

PhD defence

On Thursday 28 January 2016, Prof. Carsten Stahn contributed to the OPCW Sub-Working Group on Non-State Actors, together with Professors Andrew Clapham (Geneva) and Dapo Akande (Oxford), in the presence of the Ahmet Üzümcü, Director-General of the OPCW.

This page is under construction.

This page is under construction.

Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…

How did dynastic organization – that it, the employment of non-ruling family members and the development of dynastic traditions and concepts – influence state formation in both Catholic Europe and Muslim West-Asia?

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…

Development & Disease is one of the four research themes of the Institute of Biology Leiden.

How should we address our colonial heritage? And how digital and accessible are our collections? Outgoing State Secretary Fleur Gräper spoke with researchers and heritage specialists about this on 25 January.

How do nanoparticles bioaccumulate and biodistribute in organisms?

What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Drug Discovery & Safety and Systems Biomedicine and Pharmacology, and the Metabolomics and Analytics Centre.

Can the conditioning paradigm be used for checkpoint inhibition cancer treatment?

The work done by SUMO proteins in the cells of our body is of vital importance. Molecular cell biologist Alfred Vertegaal has been studying these proteins for nine years, first with a Veni subsidy and then with a prestigious Vidi subsidy.

What lessons can public leaders draw from crisis management? In the second Leiden Leadership Lunch in our series on ‘Leadership opportunities in times of crisis’ Dr. Jaap van Lakerveld and Dr. Jeroen Wolbers – experts in the field of crisis management – shared their insights from the recently published…

In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…