Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom

Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…

The applications of studying the early development of insects range from agriculture to material science.

Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame

The programme group Research Methods and Statistics offers support to researchers from a variety of research projects within Education and Child Studies.

Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behaviour is seen. By combining interdisciplinary expertise the ACTION consortium…

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle, Lars Jeuken and Anne Wentink.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Do understudied animals contain hidden species?

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

Connecting Agriculture, Crafts, Construction, Transport, and Resilience Strategies

Promotor: C.W.J. Beenakker, Co-promotor: M.T. Wimmer

Alice Twemlow has been named professor by special appointment in the Wim Crouwel chair in the History, Theory and Sociology of Graphic Design and Visual Culture at the Faculty of Humanities of the University of Amsterdam.

How do balanced lethal systems originate and persist in nature?

Considering the ways in which the ‘global turn’ is changing the theory and practice of historical disciplines, Explorations in History and Globalization engages with the concept and methodology of globalization, challenging traditional divisions of space and time to offer a range of perspectives on…

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

PhD defence

PhD defence

How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.

Within the Comparative Religion Network staff and graduate students from LIAS-LUCSoR (and beyond) discuss ongoing work and cooperate on key issues in the comparative and systematic study of religion.

How does contemporary art and culture represent nuclear contamination in post-nuclear landscapes?

This thesis analyses the existence and the functioning of the urban labour market in the early Roman empire by looking at the crucial influence of social structures, such as the family and non-familial labour collectives.

Promotor: S.J. Edixhoven

Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

PhD defence

Conference

Animal Sciences’ contributions to the Evolution & Biodiversity research theme include evo-devo research, the evolution of cognitive and behavioural traits, and the evolutionary mechanisms of stress adaptation. This research involves both indoor and outdoor studies.

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Supervisor: Indira Nederpelt

PhD at Université de Picardie Jules Verne, Amiens - France

The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors