2,637 search results for “discovery of the yuan” in the Public website
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Soil bacteria can produce a wealth of new antibiotics
Soil bacteria can produce a wealth of antibiotics that are new to us, claims Gilles van Wezel, Professor of Molecular Biotechnology at the Institute of Biology Leiden. His research group has developed a method that can rapidly identify and produce these unknown compounds.
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Cross-talk between stagnation points in flow and orientation
Publication in Proceedings of the National Academy of Sciences.
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European Research Council: ten years of leading research
The European Research council (ERC) was founded ten years ago today. The ERC is an important agency for research funding, including to Leiden University.
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Giant rings orbit wrong way around exoplanet
Researchers from Japan and the Netherlands who were previously involved in the discovery of an exoplanet with huge rings have now calculated that the giant rings may persist more than 100,000 years, as long as the rings orbit in the opposite direction to that of the planet around the star. Their findings…
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Zebrafish models for disease and environmental stress
We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.
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Boest: Bronze Age at its best
Prof. David Fontijn’s Economies of Destruction team was invited by Museum Midtjylland to participate in this year’s excavation in Boest, Jutland (Denmark). The exceptional site of Boest includes burial mounds, an alignment and depositions, consisting of axes, spearheads and rings, dating to the Bronze…
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New substances inhibit inflammation in the brain
Chemical biologists from Leiden, led by Dr Mario van der Stelt, have discovered substances that can reduce inflammation processes in the brain. This is a first step in the development of potential medicines for the treatment of brain diseases like Alzheimer's and Parkinson's. Published in Proceedings…
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Dark matter with a hint of Leiden shines at Dublin gallery
A glittering visualisation of dark matter by Dutch artist Thijs Biersteker is on display in the Science Gallery at Trinity College Dublin. The installation – ‘Dark Distortions’ – was inspired by Euclid, a forthcoming ESA mission to study the mysterious nature of dark matter. Leiden astronomer Henk Hoekstra…
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Pinching holes to create superconductors
In their quest for materials that conduct electricity without resistance at moderate temperatures, scientists usually work on their chemical make-up. Now Leiden physicists have come up with a radically new approach: pinching holes in a periodic pattern. Publication in SciPost.
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Literary Leiden
Quietly read a book in our new reading nook, listen to interesting and bizarre stories set in early twentieth-century Leiden, walk past literary locations in Leiden and watch the best film adapted from a Leiden novel as decided on by you. April is Literary Leiden month! A month in which we pay special…
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Alex West awarded Praemium Erasmianum Dissertation Award 2022
Alex West’s dissertation,
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MA thesis Floris Keehnen awarded with the Volkskrant thesis prize
Floris Keehnen has been awarded the Volkskrant thesis prize 2012 for his MA thesis entitled:
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Webinars
On this page you will find a collection of presentations and videos of the Florence Nightingale Colloquia, seminars at the faculty and other event recordings hosted by the Data Science Research Programme.
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Key publications
Key publications of the Predictive Pharmacology group.
- Admission & Application
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Binding kinetics
A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…
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This is the library you did not know you had been looking for
2,240 plant extracts from 1,299 different plant species of Dutch origin. That’s the collection of the Dutch Extract Library, which has recently been transferred to the Institute of Biology Leiden. To plant biologist and contact person for this library Pingtao Ding this is a true treasury. ‘To bring…
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The international tax system as a complex system
Complex systems can be characterized as systems in which multiple components interact with each other, often in non-linear ways. The main goal of this research will be to investigate if and how the international tax system can be defined and modelled as a complex system. Approaching the international…
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Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis, Nat. Comm. 2020
Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.
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Reconstructing adhesives
An experimental approach to organic palaeolithic technology
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State, Society and Labour: A Social History of Iranian Textile workers, 1906-1941
This research investigates everyday lives and workplace experiences of Iranian workers employed at textile industry, which was the second biggest industry after oil following the latter’s discovery in 1908.
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Quan/Qual analysis of drugs and metabolites in biological matrices
Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?
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Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity, Nat. Commun., 2017
The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…
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Scorescapes, On Sound, Environment and Sonic Consciousness
This doctoral trajectory explores sound, its image and its role in relating humans and our technologies to the environment.
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Orchestration of Distributed LOFAR Workflows
The LOFAR radio telescope produces petabytes of data every year. Radio Astronomers use complex multi-step pipelines to process this data and produce scientific images.
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Roman Republican Colonization
New perspectives from archaeology and ancient history
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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Next444
The Next444 project focuses on the future of interdisciplinary research at Leiden University.
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AI-SUPPORTED SYNTHESIS OF SHEPARD-RISSET FREQUENCY SETS
Implementation of the new sound synthesis and analysis method in music composition.
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Predicting the future: Predictive control for astronomical adaptive optics
The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.
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The Qasr Dakhleh Project
Director: Dr. Fred Leemhuis
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Analecta Praehistorica Leidensia 39
Excavations at Geleen-Janskamerveld 1990/1991
- Leiden Academic Centre for Drug Research
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Ukraine
This is an Erasmus+ International Credit Mobility project of the Faculty of Sciences with one partner in Ukraine.
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A large-scale crop protection bioassay data set
ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.
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Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines
Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)
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Mind the gap: gas and dust in planet-forming disks
Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond
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Pattern mining for label ranking
Promotor: J.N. Kok, Co-promotor: C.M. Soares, A.J. Knobbe
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Learning to look at LiDAR: combining CNN-based object detection and GIS for archaeological prospection in remotely-sensed data
The manual analysis of remotely-sensed data is a widespread practice in local and regional scale archaeological research, as well as heritage management.
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A Grammar of Sunwar. Descriptive Grammar, Paradigms, Texts and Glossary
This grammar provides a description of Sunwar, a Tibeto-Burman language spoken in eastern Nepal, based on data collected during twelve months of field work.
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What is Citizen Science?
In citizen science projects, citizens and scientists work together to develop new scientific knowledge.
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In silico characterization of a GPCR focused library
Supervisor: Gerard van Westen
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LUECCM
The Leiden University-European Center for Chinese Medicine and Natural Compounds (LUECCM) is a virtual research Centre bringing together research projects of many different researchers from different origin.
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TARGETBIO: Transmission of Antimicrobial Resistance Genes and Engineered DNA from Transgenic Biosystems in Nature
This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.
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Research
Computers are becoming ever more powerful and are taking on more complex tasks. The Leiden Institute of Advanced Computer Science (LIACS) contributes to revolutionary scientific research and applies the latest inventions in the field, offering answers to today’s questions of society.
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Medical Biochemistry
Medical Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University. The section is headed by Prof. Dr. Hans Aerts.
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Predicting early Alzheimer's disease stage in human
A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).
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Biological and Soft Matter Physics
Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.
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Career prospects
In the Master’s programme in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.
- Molecular Biotechnology