300 search results for “cell and” in the Staff website
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Amoeboid cell migration and physicochemical properties of the extracellular environment
PhD defence
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Leiden chemists discover new ways in which single-celled organisms organise their DNA
It has only recently been discovered that single-celled organisms (bacteria and archaea) also have histones—proteins that structure DNA. Now, Leiden PhD candidate Samuel Schwab has found that the histones in these organisms are much more diverse than previously thought. Schwab and his colleagues describe…
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The career choices of cells
How does an embryonic stem cell decide if it becomes a heart cell or a kidney cell? That’s the question computational biologist Maria Mircea studied for her PhD research. She looked at the inside of individual cells to analyse how they change. This is what she discovered.
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Willem Fibbe
Faculteit Geneeskunde
w.e.fibbe@lumc.nl | +31 71 526 2271
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Dennis Claessen
Science
d.claessen@biology.leidenuniv.nl | +31 71 527 5052
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Micha Drukker
Science
m.drukker@lacdr.leidenuniv.nl | +31 71 527 6271
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Douwe Atsma
Faculteit Geneeskunde
d.e.atsma@lumc.nl | +31 70 526 2020
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300 million euros for new international stem cell consortium
The Leiden University Medical Center (LUMC), the Danstem Institute from the University of Copenhagen and the Murdoch Children’s Research Institute in Melbourne have received 300m euros from the Novo Nordisk foundation. The aim of this new international consortium is to bring stem-cell based therapies…
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Young, sleeping memory cells are crucial in fighting a reinfection
Researchers from the Netherlands Cancer Institute, the Leiden University Medical Center (LUMC) and Oncode have created a tracking system that can reveal how often cells have divided. This allowed them to find a yet undiscovered population of immune cells: young memory cells that behave like stem cells.…
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Frank Schaftenaar
Science
f.h.schaftenaar@lacdr.leidenuniv.nl | +31 71 527 5134
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How cells talk by pulling on a fibre network
Mechanics play a larger role in blood vessel formation, and other developmental biology, than previously thought. Cells appear to respond to mechanical signals, such as pressure. Through the extracellular matrix, a network of fibrous proteins, cells can supposedly exchange those mechanical signals over…
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Bacteria without cell wall gobble up DNA from environment
A bacterium hiding from the immune system and picking up bits of DNA from its environment. The result: gaining new traits, such as better protection against antibiotics. Fortunately, we have not found such a damning scenario yet. However, PhD student Renée Kapteijn did find the first clues, which…
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Christine Mummery
Faculteit Geneeskunde
c.l.mummery@lumc.nl | +31 71 526 9300
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Tessa Vergroesen
Science
t.m.vergroesen@biology.leidenuniv.nl | +31 71 527 4912
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Véronique Ongenae
Science
v.m.a.ongenae@biology.leidenuniv.nl | +31 71 527 5075
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Ewa Snaar-Jagalska
Science
b.e.snaar-jagalska@biology.leidenuniv.nl | +31 71 527 2727
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Webinar Transfusion Medicine and Cellular and Tissue Therapies
Study information
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forming embryo to cancer metastasis: the significance of collective cell movement
Luca Giomi has the first results of his ERC consolidator grant. He discovered that epithelial cells move collectively but in different ways, depending on the scale you look at. It is hexatic at small scales, and becomes nematic at larger scales: it is a multiscale order. This collective movement of…
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Erik Danen
Science
e.danen@lacdr.leidenuniv.nl | +31 71 527 4486
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Noortje Dannenberg
Science
n.dannenberg@biology.leidenuniv.nl | +31 71 527 5075
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Joost Beltman
Science
j.b.beltman@lacdr.leidenuniv.nl | +31 71 527 4323
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Inexhaustible source of human heart muscle cells allows strong reduction of animal testing
Researchers at the Leiden University Medical Centre (LUMC) have managed to culture human heart muscle cells on a massive scale. This is an exceptional achievement because it is very difficult to replicate heart muscle cells outside the body. Using a special technique, the researchers have now created…
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Stiffness and viscosity of cells differ in cancer and other diseases
During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.
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T-cells more important in the fight against the COVID-19 virus than initially thought
A COVID-19 vaccine that specifically instructs the immune system to produce T-cells rather than antibodies is shown to provide good protection in a mouse model, Leiden University Medical Center (LUMC) researchers report in Nature Communications. According to them, the alternative vaccine may offer a…
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LUMC will administer first Dutch stem cell gene therapy to patients
Researchers and clinicians at Leiden University Medical Centre (LUMC) are about to begin a milestone clinical study. It will be the first time a stem cell gene therapy developed in the Netherlands is used in a clinic. The therapy will be used to treat children with SCID, a rare disorder where children…
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A unique defence: Bacteria lose cell wall in the presence of virus
Bacteria temporarily live without their cell wall if dangerous viruses are near. A remarkable feature, as the cell wall is a sturdy barrier against threats. Still, the discovery has a logical explanation ánd might be of a consequence for fighting pathogenic bacteria, according to Véronique Ongenae,…
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First patient in the Netherlands successfully treated with stem cell gene therapy
Researchers from the Leiden University Medical Center (LUMC) have successfully used stem cell gene therapy to treat a baby with the severe congenital immune disorder SCID. An important milestone: it is the first time stem cell gene therapy of Dutch origin has been administered to a patient, and also…
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How cells determine the fate of proteins (and can we do it too?)
Cells in our bodies are often threatened by errors in our own proteins. The FLOW consortium, comprising scientists from various institutions including Leiden, is poised to meticulously map out for the first time how cells control proteins, correcting or removing faulty ones. This endeavour holds promise…
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Caught in living cells: how bacteria regulate their genes to defend themselves
For the first time, it was shown in living cells how the bacterium E. coli regulates genes that help it survive in a new environment. Biochemist Fatema Zahra Rashid managed to do this using a technique she fine-tuned. Her research into changes in 3-dimensional chromosome structure offers clues for ways…
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EIC Pathfinder Challenge grant for research into autoreactive B cells in cardiovascular disease
At the division of BioTherapeutics, Amanda Foks, Bram Slütter and Ilze Bot have obtained a €4 million research grant from the HORIZON 2022 EIC Pathfinder Challenge “Cardiogenomics”, entitled “B-specific: B-cell related gene and protein markers with prognostic and therapeutic value for CVD”.
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How to hijack natural destruction in cells: ‘We need to understand it through and through’
Destroying proteins from the Golgi apparatus of the cell in a controlled manner. That is the focus of chemist Marta Artola’s pioneering research. By developing a groundbreaking technology to target specific proteins in the Golgi, Artola aims to unlock new ways for drug development. For this ambitious…
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Tunnel vision alarm in the search for more efficient hydrogen cells
A tenacious postdoc researcher persuaded Professor Marc Koper to research the oxygen reduction reaction. In Koper's eyes, there was little of interest there. But they promptly discovered a whole new way to improve fuel cells on hydrogen and oxygen. Their article appeared in Nature Catalysis on 07 Ju…
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Arthur Ram
Science
a.f.j.ram@biology.leidenuniv.nl | +31 71 527 4914
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Physics in the picture: cancer cells as an explosion of fireworks
When you think of physics, do you think only of complicated formulas? You’re not the only one. Therefore, every year, the Leiden Insitute of Physics organises the LION Image Award to show another side of physics: beautiful images about intriguing science. The winner of the 2022 photo competition captured…
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Marjolein Crooijmans
Science
m.e.crooijmans@biology.leidenuniv.nl | +31 71 527 5075
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Saloni Saxena
Science
s.saxena@biology.leidenuniv.nl | +31 71 527 4950
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Innovating Cell Pharmacy with stem cells
Lecture
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Marie Depuydt receives presentation award at the 10th EMBRN meeting in Utrecht
From 11-13 July 2022, the 10th EMBRN International Mast Cell and Basophil Meeting took place in the Utrecht University Academia Building in Utrecht. During this meeting, novel insights and developments in the field of mast cell and basophil biology in both health and disease were shared.
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Cell Pharmacy
Inaugural lecture
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Sander van Kasteren: from molecule builder to Professor of Chemical Immunology
Sander van Kasteren only noticed some small, subtle changes since he was appointed professor on 1 May. Still, he has to get used to the idea, even though he had been working towards the professorship for a few years. ‘I don't quite see myself as a professor yet.'
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Call: collaboration between humanities and regenerative medicine
Research
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Forces and Symmetries in Cells and Tissues
PhD defence
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Serkan Aslan
Science
s.aslan@lacdr.leidenuniv.nl | +31 71 527 5919
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Unravelling cell fate decisions through single cell methods and mathematical models
PhD defence
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Mechanisms and consequences of horizontal gene transfer in cell wall- deficient cells of Kitasatospora viridifaciens
PhD defence
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Joey Zuijdervelt
Science
j.l.zuijdervelt@lacdr.leidenuniv.nl | +31 71 527 6227
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Remko Offringa
Science
r.offringa@biology.leidenuniv.nl | +31 71 527 5097
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Single-cell immune profiling of atherosclerosis
PhD defence
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Click to Release for Immunce Cell Activation
PhD defence
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New Master’s programme in Transfusion Medicine and Cellular and Tissue Therapies
LUMC and Leiden University will start the new two-year online master's program in Transfusion Medicine and Cellular and Tissue Therapies from October 2023.