1,725 search results for “single molecule spectroscopy” in the Public website
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NACTAR: The lugdunomycins: a new class of polyketide antibiotics with unique chemical scaffold
Aim of the proposal is to develop lugdunomycin into a drug candidate able to treat infectious diseases caused by multi-drug resistant pathogens.
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New generation of graphene biosensors based on smooth surfaces and sharp edges
The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…
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Human DNA softer than DNA single-celled life
Single-celled organisms have stiffer DNA than multicellular lifeforms like humans and rice. Theoretical physicists managed to simulate the folding in full genomes for the first time to reach this conclusion. Publication in Biophysical Journal on February 7.
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Quest for new antibiotics
Gubbens
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How our single-celled relatives package their DNA
A group of single-celled organisms organises its DNA in a similar way to higher organisms such as plants, animals, and fungi. However, the way packaged DNA is read out differs between the two related groups, Bram Henneman discovered. PhD defence on 5 December.
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Participants
The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).
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Nanofluidic tools for bioanalysis: the large advantages of the nano-scale
Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)
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Sense Jan van der Molen Lab - Physics of Quantum Materials
In our lab, we investigate the physics and material properties of low-dimensional systems.
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Gold nanorod photoluminescence: applications to imaging and temperature sensing
Promotor: M.A.G.J. Orrit
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Characterization and skin permeation of ketoprofen-loaded vesicular systems
PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.
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Invited speakers
Speakers that have accepted to participate:
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Coiled-coils on lipid membranes: a new perspective on membrane fusion
Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros
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Extremely loud & incredibly far: observing radio bright AGN into the cosmic dawn
In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…
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Thrips resistance in strawberry: more fruits with less pesticides
Can thrips resistance in strawberry be explained based on secondary metabolite profiles and plant morphological traits?
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Two captains on a single ship
Caspar van den Berg was asked by Dutch news programme EditieNL for a reaction to the new coalition agreement and the ministerial team. Some ministries are set to have two ministers. Can that go well? View the excerpt.
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ParaNMR Facility
The Paramagnetic NMR Facility Leiden has been established to provide support to researchers who want to apply paramagnetic NMR spectroscopy to biomolecules. Support is offered in the design and synthesis of paramagnetic probes, either for general application (such as lanthanide tags and spin labels)…
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Shining Light on PAHs in Space
Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…
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In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
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The astrochemical factory: A solid base for interstellar reactions
In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.
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Single-use water bottles? Not on our watch.
We, as LUGO, believe that with simple everyday actions we can prevent large amounts of single-use plastic water bottles from entering our oceans.
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Ahmed Mahfouz: 'The mystery of brain diseases, unravelled cell by cell'
Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.
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Magnetism and magnetization dynamics in thin film ferromagnets
Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek
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Sander Wezenberg receives the first "C2W Molecule of the Year" award
The molecule calix[4]pyrrole, synthesised in the group of associate professor Sander Wezenberg at the Leiden Institute of Chemistry, has been voted ‘Molecule of the Year’ by the readers of C2W Mens & Molecule. Wezenberg received the award from editor Daniël Linzel.
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Platinum electrochemistry through a magnifying glass
In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.
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Atom addition reactions in interstellar ice - new pathways towards molecular complexity in space -
Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen
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Sensing drug responses of single cells using optical tweezers
Light can be used to apply forces on single cells. Focused lasers have been used by physicists to tweeze particles and to manipulate them. These so called “optical tweezers” can be used as mechanical phenotyping tools for characterising the mechanics of materials and living objects.
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Movements of steroid receptors inside the cell nucleus unraveled
Advanced fluorescence microscopy techniques have revealed how steroid receptors move inside the nucleus. The results were published by a team from Leiden University and the Erasmus Medical Center in Rotterdam, led by IBL-researcher Marcel Schaaf.
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Data mining and algorithm development
Due to the modern techniques of combinatorial chemistry and high-throughput screening, data on the biological activity of many millions of compounds is known. However, it is still very difficult to transfer this data into knowledge: if we know that compounds A and B bind to a certain protein with high…
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Research
Research at the Catalysis and Surface Chemistry group is comprised of the following research themes:
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Cathodic corrosion
Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.
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Disorder and interactions in high-temperature superconductors
This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.
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Shining Light on Interstellar Matter
Promotor: H.V.J. Linnartz
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Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
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Azure Hiptronics release single and music video 'Ocean's Edge'
Apart from his activities as coordinator of the Academy of Creative and Performing Arts, Rogier Schneemann is co-founder, guitarist and composer of the Dutch-Italian group Azure Hiptronics, originally formed in 2006.
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Inferno Worlds
A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.
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Bernd Schneider
Dr. at Max Planck Institute for chemical Ecology, Jena - Germany
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Unveiling the invisible conformational landscape of cytochrome P450
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Quan/Qual analysis of drugs and metabolites in biological matrices
Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?
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Surface-structure dependencies in catalytic reactions
Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink
- Leiden Academic Centre for Drug Research
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Strategy
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.
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Development of new antibiotics from plant-originated products
Utilization of plant-originated products as new antibiotics
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Programme
The symposium is open to all registered participants and consists of a two-day programme and a poster session.
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Galaxy formation traced by heavy element pollution
Galaxies form and evolve through close interaction with their surroundings. As a result, the heavy elements ('metals') that are synthesized in stars, are found both inside and outside galaxies.
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From the root of variation: A metabolomics perspective to plant soil-feedback
By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.
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Substrate adaptability of β-lactamase
The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…
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Redox catalysis for a sustainable energy infrastructure
The main research theme in the group of Dennis Hetterscheid is to understand and mimic bioinorganic multi-electron processes that are relevant to our future energy infrastructure. Reduction of protons generates hydrogen that can be used as a chemical fuel. Alternatively to gaseous hydrogen, the reduction…
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High-throughput quantification and unambiguous identification for metabolomics
The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.
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Bioorthogonal Antigens
The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.
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Our approach
Our group operates at the cross-roads of different disciplines: molecular and cellular microbiology, biochemistry, structural biology and biophysics. The group harbors expertise in a multitude of molecular and cellular approaches including: