The work presented in this thesis addresses the role of the locus coeruleus (LC) - norepinephrine (NE) system in various aspects of human cognition, and the modulation of brain state.

Brain researcher Elseline Hoekzema has discovered that the structure of the brain changes during pregnancy, particularly those areas related to social functions. These changes persist for at least two years after the mother gives birth. Publication in Nature Neuroscience on 19 December.

Children and adolescents really do use their ‘smart’ brain areas. This has been confirmed by an extensive and long-running study of the brain carried out by developmental psychologist Sabine Peters . Her findings can have important consequences for education. PhD defence 27 January.

At science festival 'Over de kop', surprising brain facts alternate with confronting stories from the operating room. Researchers explain why our brains love beans and why you should never ride a racing bike without a helmet.

Based on the results of a language-switching experiment, PhD candidate Fatemeh (Simeen) Tabassi Mofrad MA and Professor Niels Schiller have discovered that the traditional categorisation of brain areas is not sufficient. They published their research findings in the scientific journal NeuroImage.

What effect did the lockdown have on young people? Leiden researchers started a study of this in the first year of the covid pandemic. They discovered an impact on the development of the brain areas involved in social behaviour. The researchers published their discovery in Scientific Reports at Nat…

Adolescents who were more popular among their classmates in junior school are often the ones who are more inclined to share things fairly with others. During this sharing process, 'social' areas of the brain are more strongly activated than in adolescents who are less popular. This is the finding of…

Are disturbances to the brain, such as Alzheimer's or autism, linked to specific defects in the underlying communication networks in the brain? If this is the case, subtle changes in the networks can act as a marker for brain disturbances. Neuroscientist Serge Rombouts will be investigating this, together…

Chemical biologists from Leiden, led by Dr Mario van der Stelt, have discovered substances that can reduce inflammation processes in the brain. This is a first step in the development of potential medicines for the treatment of brain diseases like Alzheimer's and Parkinson's. Published in Proceedings…

Women are more often diagnosed with depression, whereas ADHD is much more frequently detected in men. And there are other more striking differences. What role does the brain play in mental health and what is the influence of the environment? For answers to these questions, listen to the ‘(Un)gendered…

A tried and tested medication for treating ADHD works differently than expected in the brains of healthy individuals during rest: rather than stimulating brain activity, it suppresses it.

Under 18, no alcohol. In spite of this slogan, adolescents still have access to alcohol. But how harmful is that one beer for the adolescent brain? Research, including in Leiden, may provide the answer.

Novel language learning activates different neural processes than was previously thought. A Leiden research team has discovered parallel but separate contributions from the hippocampus and Broca's area, the learning centre in the left hemisphere. The right hemisphere of the brain also seems to play…

Using musical cues to learn a physical task significantly develops an important part of the brain, according to a new study co-authored by Leiden psychologist Rebecca Schaefer. The results are published in the journal Brain & Cognition.

For many years, scientists have observed a correlation between Alzheimer’s disease and a surplus of iron in the brain. However, a causal link between the two has not been proven yet. We lack knowledge concerning the specific form of iron that is involved in the development of neurodegenerative diseases.…

There is greater variety in the size of men’s brains than of women’s. This could help explain why some psychiatric disorders such as ADHD and autism are more prevalent in boys. Leiden brain researcher Lara Wierenga has published an article about this in the international journal Cerebral Cortex.

There seem to be genes that influence how our brains develop over time. A large international consortium has discovered this with an extensive study. The results of the study were recently published in Nature Neuroscience.

On Sept. 29, Lara Wierenga, together with graphic designer Dirma Janse, presented their new book Atlas of our Brain. In the presence of fellow scientists and other interested parties, they shared some of the stunning illustrations and mind-boggling facts that can be found in the book.

Leiden University will appoint Dr Anne-Laura van Harmelen as Professor of Brain, Security and Resilience at the Institute of Education and Child Studies with effect from 1 September 2020. She will focus on the brain in relation to the development of transgressive behaviour and its prevention and tre…

Hoping to learn something about the human brain, Leiden researchers are creating a setup to shoot single photons, particles of light, into someone’s eye. ‘The eye is a passageway to the brain.’

Autism, Alzheimer’s, and bipolar disorder: can the development of these mental health conditions be influenced by the ketogenic diet? Increasingly, research suggests it might. 'For those it helps, it can be life-changing,' says neuroscientist Eline Dekeyster.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Young people influence one another to take greater risks, although it's not quite that cut and dried. This is what development psychologist Jorien van Hoorn discovered. Peers also have a positive influence on one another, an aspect that has so far been under-researched. PhD defence 12 January.

Tiny selenium particles could have a therapeutic effect on ischemic brain strokes by promoting the recovery of brain damage. Pharmacologists, including Alireza Mashaghi from the Leiden Academic Centre for Drug Research discovered that selenium nanoparticles inhibit molecular mechanisms that are responsible…

The updated MRI scanner at the Leiden Institute for Brain and Cognition (LIBC) will become operational on 29 September. The new version is faster and better than the current model.

What is the effect of training children to exercise self-control? Niko Steinbeis has been awarded a major European subsidy to find the answer to this question. The innovative aspects of this research are the target group, an individual approach to the training and examining the child brain the scann…

How does the brain develop from birth up to adolescence? And why are young people given so little information about the development of their brain? Two new websites of the Leiden Institute for Brain and Cognition provide an answer.

What effect does bullying have on the brain? This is just one of the key research questions included in the NeuroLabNL science agenda. Scientists presented the agenda to Minister Van Engelshoven (Education, Culture and Science) and Minister Dekker (Justice and Security) on 3 July at Campus The Hagu…

Developmental psychologist Barbara Braams has been awarded with a Veni funding for her research about risk behaviour in young people. This award offers Braams the opportunity to develop her ideas over a period of three years.

An MRI scanner is much more than a machine alone. It is an extremely versatile technique that provides numerous opportunities for finding out more about the workings of the human brain, says Thijs van Osch, Professor of Radiology, with a particular emphasis on experimental cerebrovascular imaging. Inaugural…

Developmental psychologist Barbara Braams has moved to Harvard University to study social influences on adolescents’ decision making in risky and ambiguous situations. NWO awarded her a Rubicon grant for talented scientists who have recently obtained a PhD.

Suddenly getting lost, failing to recognise family members, or forgetting words and names are well-known symptoms of Alzheimer's disease. Psychologists have now discovered that the disease also manifests in more subtle ways: through the rhythm of finger tapping.

Ellen de Bruijn and Berna Güroğlu, both of the Psychology Institute, have been proposed for professorships by the Faculty of Social and Behavioural Sciences. Güroğlu: ‘I feel honoured that the University has approved the appointment.’ De Bruijn: ‘It’s great, and really motivating, that Leiden University…