708 search results for “acoustic signal” in the Public website
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Tone and intonation processing: From ambiguous acoustic signal to linguistic representation
On November 1st, Min Liu succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Min on this great result.
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Carel ten Cate
Science
c.j.ten.cate@biology.leidenuniv.nl | +31 71 527 5040
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Lipid signaling in brain diseases
Multiple Sclerosis, Parkinson’s and Alzheimer’s disease are the most common neurodegenerative disorders. Unfortunately, no effective treatments are currently available to halt the progression of these neuroinflammatory diseases [1].
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Cell adhesion signaling: dynamics, migration, and metastasis
Cell adhesion signaling
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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Chemokine signaling in Tuberculosis and Salmonella infection
Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?
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Urban ecology and avian acoustics: Function and evolution of birdsong in a changing world
Birds sing to be heard, but how do they cope with increasing noise levels? Which species persist in cities and why? And do they thrive or suffer in the urban soundscape?
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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relationship between linguistic and speaker- dependent information in the acoustics of consonants
On the 28th of June, Laura Smorenburg successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Laura on this achievement!
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Sound of Mind: electrophysiological and behavioural evidence for the role of context, variation and informativity in human speech processing
In this dissertation, electrophysiological (EEG) and behavioural measures are used to investigate how allophonic tonal variants and sub-phonemic features are processed during Mandarin and Dutch speech production, visual processing of written words and reading aloud.
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APELAFICO: Acoustic ecology of PELAgic FIsh COmmunities: A study into the effects of construction and operation of wind farms
Do offshore windfarms affect the local biodiversity of the pelagic fish community and are fish deterred or attracted by sounds?
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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AGC3 kinases and calmodulins in plant growth responses to abiotic signals
Promotor: Prof.dr. P. Hooykaas, Co-promotor: Dr. R. Offringa
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Computational Approaches to Disease, Signaling and Drug Targets
The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.
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Dynamics of TNFalpha signaling and drug-related toxicity
In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.
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Signalling pathways that control development and antibiotic production in streptomyces
Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.
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Evolution & Biodiversity in Animal Sciences
Animal Sciences’ contributions to the Evolution & Biodiversity research theme include evo-devo research, the evolution of cognitive and behavioural traits, and the evolutionary mechanisms of stress adaptation. This research involves both indoor and outdoor studies.
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Polar auxin transport: translating environmental signals into plant developmental responses
1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…
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microscopy-based drug target discovery in pathogen-meidated inflammatory respons signalling
Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…
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Motivational signals in public sector job advertisements and how they relate to attracting and hiring candidates
This article examines how motivational signals in job advertisements relate to public employers’ recruitment success.
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Lipid signaling and inflammation: metabolomics for better diagnosis and treatment strategy
Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…
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Unraveling the role of signaling networks controlled by Grainyhead like transcription factor in breast cancer subtypes
This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…
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Chemokine signaling mechanisms underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition
Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.
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Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity, Nat. Commun., 2017
The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…
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Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and
Source: Mol Psychiatry (2015)
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development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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Applications of multisource data-based dynamic modeling to cell-cell signaling and infectious disease spreading
The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…
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Handbook of Signal Processing Systems
Handbook of Signal Processing Systems is organized in four parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications;…
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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Freedom of additional signals on genes: on the combination of DNA mechanics, genetics and translation speed
DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.
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Two-Prover Bit-Commitments: Classical, Quantum and Non-Signaling
This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.
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significance of the glucocorticoid and mineralocorticoid receptor signaling in the innate immune system
Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.
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Gabriel Paiuk on The Construction of an Imaginary Acoustic Space
On 23 March a Sonology concert took place in the Arnold Schönbergzaal at the Royal Conservatoire, dedicated to Gabriel Paiuk’s The Construction of an Imaginary Acoustic Space, a composition for ensemble and electronics performed by New European Ensemble.
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Premiere of The Construction of an Imaginary Acoustic Space
The Construction of an Imaginary Acoustic Space, a new work by ACPA PhD Candidate Gabriel Paiuk was premiered last Saturday at the Universität Mozarteum in Salzburg. The piece was commissioned by the österreichisches ensemble für neue musik for their second yearly concert series.
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Music production and its role in coalition signaling during foraging contexts in a hunter-gatherer society
For the first time, a group of international and interdisciplinary researchers led by Karline Janmaat and her former MSc Student Chirag Chittar, have tested the several hypotheses on music simultaneously in a modern foraging society during their daily search for tubers – their staple food. They found…
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Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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Hypoxic Signalling and Tuberculosis
IBL-researcher Phil Elks in the group of Annemarie Meijer won the Cell Observatory Publication of the Year 2013. He received the award for his paper in PLoS Pathogens, showing that activation of hypoxia signaling protects against mycobacterial infection.
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Aria of the Dutch North Sea
Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn
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Development & Disease in Animal Sciences
Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.
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Towards a Cognitive Neuroscience of Prosody Perception and its Modulation by Alexithymia
This dissertation examines what network in the human brain is involved in the perception of prosody and whether activity within this network is modulated by the personality trait alexithymia.
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Katharina Riebel
Science
k.riebel@biology.leidenuniv.nl | +31 71 527 5149
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Origin of Neutrino Signal Remains a Mystery
Physicists have studied the astrophysical neutrino signal as reported by the IceCube collaboration from a different angle with their ANTARES detector. The Milky Way centre was an obvious prime suspect to be a source, but this hypothesis is now only closer to debunked than confirmed. Publication in Physical…
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Clear signal from ICJ in Gaza conflict
While the interim ruling passed down by the International Court of Justice did not order a ceasefire, it did state that Israel must take all measures to prevent further victims and genocidal acts in Gaza. South Africa brought the case as it alleges that the war in Gaza constitutes a violation of the…
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Ruben Huele
Science
huele@cml.leidenuniv.nl | +31 71 527 FLEX
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Stable single molecules for quantum optics and all-optical switches
Promotor: Prof.dr. M.A.G.J. Orrit
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar